Design and Safety of Phytobiotics with Beneficial Vaginal Lactobacilli for the Prevention of Urogenital Tract lnfections

MARCHESI, ANTONELLA; SILVA, JESSICA; DE GREGORIO, PRISCILA; WIESE, BIRGITT; VIGNOLO, GRACIELA, .; NADER, MARIA ELENA

Praga

Congreso; International Scientific Conference. Probiotics, Prebiotics, Gut Microbiota and Health; 2019

IPC

Vegetal extracts are applied to decrease or counteract Urogenital Tract lnfections (UGTI) symptoms, most of them produced as a consequence of vaginal microbioma disbiosis, and host genetic polymorphism. Lactobacilli are the dominant bacteria in human vagina, exerting different effects on healthy, sexually active and pregnant women. The complementation of phytoderivatives and beneficial vaginal lactobacilli (BVL) can be used to restore the ecological equilibrium of vaginal microbioma and prevent UGTI, which represent deleterious effects mainly in pregnant women and newborn with high costs in public health. The objective of this study was to evaluate the compatibility between phytoderivatives and BVL and their safety for the design of phytobiotic formulas for UGTI.