ZHAO, ZHUORAN; SHEN, XIAYU; CHEN, SHUANG; GU, JING; WANG, HAUN; MOJICA, MARIA F.; SAMANTA, MOUMITA; BHOWMIK, DEBSINDHU; VILA, ALEJANDRO J.; BONOMO, ROBERT A.; HAIDER, SHOZEB

Gating interactions steer loop conformational changes in the active site of the L1 metallo-β-lactamase

eLife; Año: 2023 vol. 12

SZUSTER, JONATHAN; LEGUTO, ALCIDES J.; ZITARE, ULISES A.; REBECHI, JUAN P.; VILA, ALEJANDRO J.; MURGIDA, DANIEL H.

Electrochemical characterization of an engineered red copper protein featuring an unprecedented entropic control of the reduction potential

BIOELECTROCHEMISTRY; Año: 2022 vol. 146 p. 108095 - 108095

ROJAS, LAURA J.; YASMIN, MOHAMAD; BENJAMINO, JACQUELYNN; MARSHALL, STEVEN M.; DERONDE, KAILYNN J.; KRISHNAN, NIKHIL P.; PEREZ, FEDERICO; COLIN, ANDREW A.; CARDENAS, MONICA; MARTINEZ, OCTAVIO; PÉREZ-CARDONA, ARMANDO; RHOADS, DANIEL D.; JACOBS, MICHAEL R.; LIPUMA, JOHN J.; KONSTAN, MICHAEL W.; VILA, ALEJANDRO J.; SMANIA, ANDREA; MACK, ANDREW R.; SCOTT, JACOB G.; ADAMS, MARK D.; ABBO, LILIAN M.; BONOMO, ROBERT A.

Genomic heterogeneity underlies multidrug resistance in Pseudomonas aeruginosa: A population-level analysis beyond susceptibility testing

PLOS ONE; Año: 2022 vol. 17

LE, CASIN; PIMENTEL, CAMILA; PASTERAN, FERNANDO; TUTTOBENE, MARISEL R.; SUBILS, TOMÁS; ESCALANTE, JENNY; NISHIMURA, BRENT; ARRIAGA, SUSANA; CARRANZA, AIMEE; MEZCORD, VYANKA; VILA, ALEJANDRO J.; CORSO, ALEJANDRA; ACTIS, LUIS A.; TOLMASKY, MARCELO E.; BONOMO, ROBERT A.; RAMÍREZ, MARIA SOLEDAD

Human Serum Proteins and Susceptibility of Acinetobacter baumannii to Cefiderocol: Role of Iron Transport

Biomedicines; Año: 2022 vol. 10

BAHR, GUILLERMO; GONZÁLEZ, LISANDRO J.; VILA, ALEJANDRO J.

Metallo-β-lactamases and a tug-of-war for the available zinc at the host–pathogen interface

CURRENT OPINION IN CHEMICAL BIOLOGY.; Año: 2022 vol. 66

MOJICA, MARIA F; ROSSI, MARIA-AGUSTINA; VILA, ALEJANDRO J; BONOMO, ROBERT A

The urgent need for metallo-β-lactamase inhibitors: an unattended global threat

LANCET INFECTIOUS DISEASES; Año: 2022 vol. 22

LÓPEZ, CAROLINA; DELMONTI, JULIANA; BONOMO, ROBERT A.; VILA, ALEJANDRO J.

Deciphering the evolution of metallo-β-lactamases: A journey from the test tube to the bacterial periplasm

JOURNAL OF BIOLOGICAL CHEMISTRY; Año: 2022 vol. 298

ROSSI, MARIA-AGUSTINA; PALZKILL, TIMOTHY; ALMEIDA, FABIO C L; VILA, ALEJANDRO J

Slow Protein Dynamics Elicits New Enzymatic Functions by Means of Epistatic Interactions

MOLECULAR BIOLOGY AND EVOLUTION; Año: 2022 vol. 39

MCCANN, CAT; QUINTEROS, MICHAEL; ADELUGBA, IFEOLUWA; MORGADA, MARCOS N.; CASTELBLANCO, AIDA R.; DAVIS, EMILY J.; LANZIROTTI, ANTONIO; HAINER, SARAH J.; VILA, ALEJANDRO J.; NAVEA, JUAN G.; PADILLA-BENAVIDES, TERESITA

The mitochondrial Cu+ transporter PiC2 (SLC25A3) is a target of MTF1 and contributes to the development of skeletal muscle in vitro

Frontiers in Molecular Biosciences; Año: 2022 vol. 9

COLQUE, CLAUDIA A.; ALBARRACÍN ORIO, ANDREA G.; TOMATIS, PABLO E.; DOTTA, GINA; MORENO, DIEGO M.; HEDEMANN, LAURA G.; HICKMAN, RACHEL A.; SOMMER, LEA M.; FELIZIANI, SOFÍA; MOYANO, ALEJANDRO J.; BONOMO, ROBERT A.; JOHANSEN, HELLE K.; MOLIN, SØREN; VILA, ALEJANDRO J.; SMANIA, ANDREA M.

Longitudinal Evolution of the Pseudomonas-Derived Cephalosporinase (PDC) Structure and Activity in a Cystic Fibrosis Patient Treated with β-Lactams

mBio; Año: 2022 vol. 13

LE, CASIN; PIMENTEL, CAMILA; PASTERAN, FERNANDO; TUTTOBENE, MARISEL R.; SUBILS, TOMÁS; ESCALANTE, JENNY; NISHIMURA, BRENT; ARRIAGA, SUSANA; CARRANZA, AIMEE; MEZCORD, VYANKA; VILA, ALEJANDRO J.; CORSO, ALEJANDRA; ACTIS, LUIS A.; TOLMASKY, MARCELO E.; BONOMO, ROBERT A.; RAMÍREZ, MARIA SOLEDAD

Human Serum Proteins and Susceptibility of Acinetobacter baumannii to Cefiderocol: Role of Iron Transport

Biomedicines; Año: 2022 vol. 10

ROSSI, MARIA-AGUSTINA; MARTINEZ, VERONICA; HINCHLIFFE, PHILIP; MOJICA, MARIA F.; CASTILLO, VALERIE; MORENO, DIEGO M.; SMITH, RYAN; SPELLBERG, BRAD; DRUSANO, GEORGE L.; BANCHIO, CLAUDIA; BONOMO, ROBERT A.; SPENCER, JAMES; VILA, ALEJANDRO J.; MAHLER, GRACIELA

2-Mercaptomethyl-thiazolidines use conserved aromatic–S interactions to achieve broad-range inhibition of metallo-β-lactamases

Chemical Science; Año: 2021

ANTELO, GIULIANO T.; VILA, ALEJANDRO J.; GIEDROC, DAVID P.; CAPDEVILA, DAIANA A.

Molecular Evolution of Transition Metal Bioavailability at the Host–Pathogen Interface

TRENDS IN MICROBIOLOGY; Año: 2021 vol. 29 p. 441 - 457

A.J.LEGUTO; SMITH, MA; MORGADA, MARCOS; ZITARE, ULISES A.; MURGIDA, D; LANCASTER KM; A. J. VILA

Dramatic Electronic Perturbations of CuA Centers via Subtle Geometric Changes

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY; Lugar: Washington; Año: 2021 vol. 141 p. 1373 - 1381

LÓPEZ, CAROLINA; PRUNOTTO, ALESSIO; BAHR, GUILLERMO; BONOMO, ROBERT A.; GONZÁLEZ, LISANDRO J.; PERARO, MATTEO DAL; VILA, ALEJANDRO J.

Specific protein-membrane interactions promote packaging of metallo-β-lactamases into outer membrane vesicles

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY; Año: 2021 vol. 65

MARTÍNEZ, MELINA M.B.; BONOMO, ROBERT A.; VILA, ALEJANDRO J.; MAFFÍA, PAULO C.; GONZÁLEZ, LISANDRO J.

On the Offensive: The Role of Outer Membrane Vesicles in the Successful Dissemination of New Delhi Metallo-b-lactamase (NDM-1)

mBio; Año: 2021 vol. 12

MARTINEZ, JASMINE; RAZO-GUTIERREZ, CHELSEA; LE, CASIN; COURVILLE, ROBERT; PIMENTEL, CAMILA; LIU, CHRISTINE; FUNG, SAMMIE E.; TUTTOBENE, MARISEL R.; PHAN, KIMBERLY; VILA, ALEJANDRO J.; SHAHRESTANI, PARVIN; JIMENEZ, VERONICA; TOLMASKY, MARCELO E.; BECKA, SCOTT A.; PAPP-WALLACE, KRISZTINA M.; BONOMO, ROBERT A.; SOLER-BISTUE, ALFONSO; SIEIRA, RODRIGO; RAMIREZ, MARIA SOLEDAD

Cerebrospinal fluid (CSF) augments metabolism and virulence expression factors in Acinetobacter baumannii

Scientific Reports; Año: 2021 vol. 11

BAHR, GUILLERMO; GONZÁLEZ, LISANDRO J.; VILA, ALEJANDRO J.

Metallo-β-lactamases in the Age of Multidrug Resistance: From Structure and Mechanism to Evolution, Dissemination, and Inhibitor Design

CHEMICAL REVIEWS.; Año: 2021 vol. 121 p. 7957 - 8094

HINCHLIFFE, PHILIP; MORENO, DIEGO M.; ROSSI, MARIA-AGUSTINA; MOJICA, MARIA F.; MARTINEZ, VERONICA; VILLAMIL, VALENTINA; SPELLBERG, BRAD; DRUSANO, GEORGE L.; BANCHIO, CLAUDIA; MAHLER, GRACIELA; BONOMO, ROBERT A.; VILA, ALEJANDRO J.; SPENCER, JAMES

2-Mercaptomethyl Thiazolidines (MMTZs) Inhibit All Metallo-β-Lactamase Classes by Maintaining a Conserved Binding Mode

ACS Infectious Diseases; Año: 2021 vol. 7 p. 2697 - 2706

MORGADA, MARCOS N.; LLASES, MARÍA-EUGENIA; GIANNINI, ESTEFANÍA; CASTRO, MARÍA-ANA; ALZARI, PEDRO M.; MURGIDA, DANIEL H.; LISA, MARÍA-NATALIA; VILA, ALEJANDRO J.

Unexpected electron spin density on the axial methionine ligand in CuA suggests its involvement in electron pathways

CHEMICAL COMMUNICATIONS; Año: 2020 vol. 56 p. 1223 - 1226

MACK, ANDREW R.; BARNES, MELISSA D.; TARACILA, MAGDALENA A.; HUJER, ANDREA M.; HUJER, KRISTINE M.; CABOT, GABRIEL; FELDGARDEN, MICHAEL; HAFT, DANIEL H.; KLIMKE, WILLIAM; VAN DEN AKKER, FOCCO; VILA, ALEJANDRO J.; SMANIA, ANDREA; HAIDER, SHOZEB; PAPP-WALLACE, KRISZTINA M.; BRADFORD, PATRICIA A.; ROSSOLINI, GIAN MARIA; DOCQUIER, JEAN-DENIS; FRÈRE, JEAN-MARIE; GALLENI, MORENO; HANSON, NANCY D.; OLIVER, ANTONIO; PLÉSIAT, PATRICK; POIREL, LAURENT; NORDMANN, PATRICE; PALZKILL, TIMOTHY G.; JACOBY, GEORGE A.; BUSH, KAREN; BONOMO, ROBERT A.

A standard numbering scheme for class metallo beta-lactamases

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY; Año: 2020 vol. 64

M.D. ADAMS; PASTERAN, F; TRAGLIA, G.M.; MARTINEZ, JASMINE; HUANG, F.; LIU, CHRISTINE; FERNANDEZ, JENNIFER S.; LOPEZ, CAROLINA; GONZALEZ, LISANDRO J.; ALBORNOZ, E; CORSO, ALEJANDRA; A.J. VILA; BONOMO, ROBERT A.; RAMIREZ, MARIA SOLEDAD

Distinct mechanisms of dissemination of NDM-1 metallo-β-lactamase in acinetobacter species in Argentina

Antimicrobial Agents and Chemotherapy; Lugar: Washington DC; Año: 2020 vol. 64 p. 1 - 6

SZUSTER, JONATHAN; ZITARE, ULISES A.; CASTRO, MARÍA A.; LEGUTO, ALCIDES J.; MORGADA, MARCOS N.; VILA, ALEJANDRO J.; MURGIDA, DANIEL H.

CuA-based chimeric T1 copper sites allow for independent modulation of reorganization energy and reduction potential

Chemical Science; Año: 2020 vol. 11 p. 6193 - 6201

PALACIOS, ANTONELLA R.; ROSSI, MARÍA-AGUSTINA; MAHLER, GRACIELA S.; VILA, ALEJANDRO J.

Metallo‐β‐lactamase inhibitors inspired on snapshots from the catalytic mechanism

Biomolecules; Año: 2020 vol. 10

ZITARE, ULISES A.; SZUSTER, JONATHAN; SANTALLA, MARÍA C.; MORGADA, MARCOS N.; VILA, ALEJANDRO J.; MURGIDA, DANIEL H.

Dynamical effects in metalloprotein heterogeneous electron transfer

ELECTROCHIMICA ACTA; Año: 2020 vol. 342

HUANG, FANNY; FITCHETT, NOELLE; RAZO-GUTIERREZ, CHELSEA; LE, CASIN; MARTINEZ, JASMINE; RA, GRACE; LOPEZ, CAROLINA; GONZALEZ, LISANDRO J.; SIEIRA, RODRIGO; VILA, ALEJANDRO J.; BONOMO, ROBERT A.; RAMIREZ, MARIA SOLEDAD

The H-NS regulator plays a role in the stress induced by carbapenemase expression in acinetobacter baumannii

mSphere; Año: 2020 vol. 5

RODGERS, DEJA; PASTERAN, FERNANDO; CALDERON, MANUEL; JABER, SARA; TRAGLIA, GERMAN M.; ALBORNOZ, EZEQUIEL; CORSO, ALEJANDRA; VILA, ALEJANDRO J.; BONOMO, ROBERT A.; ADAMS, MARK D.; RAMÍREZ, MARÍA SOLEDAD

Characterisation of ST25 NDM-1-producing Acinetobacter spp. strains leading the increase in NDM-1 emergence in Argentina

Journal of Global Antimicrobial Resistance; Año: 2020 vol. 23 p. 108 - 110

PRUNOTTO, ALESSIO; BAHR, GUILLERMO; GONZÁLEZ, LISANDRO J.; VILA, ALEJANDRO J.; DAL PERARO, MATTEO

Molecular Bases of the Membrane Association Mechanism Potentiating Antibiotic Resistance by New Delhi Metallo-β-lactamase 1

ACS Infectious Diseases; Año: 2020 vol. 6 p. 2719 - 2731

LÓPEZ, C; AYALA,JA; BONOMO, ROBERT A.; GONZALEZ, LISANDRO J.; A. J. VILA

Protein determinants of dissemination and host specificity of Metallo- beta-lactamases

NATURE COMMUNICATIONS; Año: 2019

MACK AR; A. J. VILA; ROBERT A. BONOMO

A standard numbering scheme for class C β-lactamases

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY; Lugar: Washington; Año: 2019

MOJICA, MARIA F.; ABRIATA LA; A. J. VILA; BONOMO, ROBERT A.

Population Structure, Molecular Epidemiology, and beta-Lactamase Diversity among Stenotrophomonas maltophilia Isolates in the United States

MBio; Año: 2019

MARTINEZ, JASMINE; FERNANDEZ, JENNIFER S.; LIU, CHRISTINE; HOARD, AMPARO; MENDOZA, ANTHONY; NAKANOUCHI, JUN; RODMAN, NYAH; COURVILLE, ROBERT; TUTTOBENE, MARISEL R.; LOPEZ, CAROLINA; GONZALEZ, LISANDRO J.; SHAHRESTANI, PARVIN; PAPP-WALLACE, KRISZTINA M.; VILA, ALEJANDRO J.; TOLMASKY, MARCELO E.; BONOMO, ROBERT A.; SIEIRA, RODRIGO; RAMIREZ, MARIA SOLEDAD

Human pleural fluid triggers global changes in the transcriptional landscape of Acinetobacter baumannii as an adaptive response to stress

Scientific Reports; Año: 2019 vol. 9

ZITARE, ULISES A.; SZUSTER, J; SANTALLA, M.C; LLASES, MARÍA EUGENIA; MORGADA, MARCOS N.; A. J. VILA; MURGIDA, DANIEL H.

Fine tuning of functional features of the CuA site by loop-directed mutagenesis

INORGANIC CHEMISTRY; Lugar: Washington; Año: 2019 vol. 58 p. 2149 - 2157

ROSS, MO; FISHER, OS; MORGADA, MARCOS N.; KRZYANIAK MD; WASIELEWSKI MR; A. J. VILA; HOFFMAN BM; ROSENZWEIG AC.

Formation and electronic structure of an atypical CuA site

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY; Lugar: Washington; Año: 2019 vol. 141 p. 4678 - 4686

LLASES, MARÍA EUGENIA; LISA, MARIÁ-NATALIA; MORGADA, MARCOS N.; GIANNINI, ESTEFANÍA; ALZARI, P.; A. J. VILA

A. thaliana Hcc1 is a Sco-like metallochaperone for CuA assembly in Cytochrome c Oxidase

FEBS JOURNAL; Lugar: Londres; Año: 2019 vol. 287 p. 749 - 762

SOMA, SHIVATHEJA; MORGADA, MARCOS N.; NAIK, MANDAR T.; BOULET, AREN; ROESLER, ANNA A.; DZIUBA, NATHANIEL; GHOSH, ALOK; YU, QINHONG; LINDAHL, PAUL A.; AMES, JAMES B.; LEARY, SCOT C.; VILA, ALEJANDRO J.; GOHIL, VISHAL M.

COA6 Is Structurally Tuned to Function as a Thiol-Disulfide Oxidoreductase in Copper Delivery to Mitochondrial Cytochrome c Oxidase

Cell Reports; Lugar: Amsterdan; Año: 2019 vol. 29 p. 4114 - 4126

MORGADA, MARCOS N.; EMILIANI, F; CHACÓN, KN; ALVAREZ-PAGGI, DAMIAN; MURGIDA, D; BLACKBURN NJ; ABRIATA, LUCIANO A.; A. J. VILA

pH-induced binding of the axial ligand in an engineered CuA site favors the πu state

INORGANIC CHEMISTRY; Lugar: Washington; Año: 2019 vol. 58 p. 15687 - 15691

LLASES, MARÍA EUGENIA; MORGADA, MARCOS N.; A. J. VILA

Biochemistry of Copper Site Assembly in Heme-Copper Oxidases: A Theme with Variations

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES; Lugar: Basel; Año: 2019 vol. 20

GIANNINI, ESTEFANÍA; GONZÁLEZ, LISANDRO J.; VILA, ALEJANDRO J.

A simple protocol to characterize bacterial cell-envelope lipoproteins in a native-like environment

PROTEIN SCIENCE; Año: 2019 vol. 28 p. 2004 - 2010

L. J. GONZÁLEZ ; C. STIVAL ; J.L. PUZZOLO; D.M. MORENO ; VILA AJ

Shaping substrate selectivity in a broad spectrum metallo-β-lactamase

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY; Año: 2018 vol. 62

U. A. ZITARE; J. SZUSTER; M.F. SCOCOZZA; A.ESPINOZA-CARA; A.J.LEGUTO; M.N.MORGADA; A.J. VILA ; D.H. MURGIDA

The Role of Molecular Crowding in Long-Range Metalloprotein Electron Transfer: Dissection into Site- and Scaffold-Specific Contributions

ELECTROCHIMICA ACTA; Lugar: Amsterdam; Año: 2018

PALACIOS, ANTONELA R.; MARIA F. MOJICA; GIANNINI, ESTEFANÍA; BONOMO, ROBERT A.; A. J. VILA

The Reaction Mechanism of Metallo-β-lactamases is Tuned by the Conformation of an Active Site Mobile Loop

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY; Año: 2018

A. ESPINOZA-CARA, ; U.A. ZITARE, ; D. ALVAREZ-PAGGI,; D.H. MURGIDA; A.J. VILA

Engineering a bifunctional copper site in the cupredoxin fold by loop-directed mutagenesis

Chemical Science; Año: 2018

TIMÓN-GÓMEZ, ALBA; NÝVLTOVÁ, EVA; ABRIATA, LUCIANO A.; VILA, ALEJANDRO J.; HOSLER, JONATHAN; BARRIENTOS, ANTONI

Mitochondrial cytochrome c oxidase biogenesis: Recent developments

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY; Año: 2017 vol. 76 p. 163 - 178

BAHR, GUILLERMO; VITOR-HOREN, LUISINA; BETHEL, CHRISTOPHER R.; BONOMO, ROBERT A.; GONZALEZ, LISANDRO J.; VILA, ALEJANDRO J.

Clinical Evolution of New Delhi Metallo-β-Lactamase (NDM) optimizes resistance under Zn(II) Deprivation

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY; Año: 2017 vol. 62

MARSHALL, STEVEN; HUJER, ANDREA M.; ROJAS, LAURA J.; PAPP-WALLACE, KRISZTINA M.; HUMPHRIES, ROMNEY M.; SPELLBERG, BRAD; HUJER, KRISTINE M.; MARSHALL, EMMA K.; RUDIN, SUSAN D.; PEREZ, FEDERICO; WILSON, BRIGID M.; WASSERMAN, RONALD B.; CHIKOWSKI, LINDA; PATERSON, DAVID L.; VILA, ALEJANDRO J.; VAN DUIN, DAVID; KREISWIRTH, BARRY N.; CHAMBERS, HENRY F.; FOWLER, VANCE G.; JACOBS, MICHAEL R.; PULSE, MARK E.; WEISS, WILLIAM J.; BONOMO, ROBERT A.

Can ceftazidime-avibactam and aztreonam overcome β-lactam resistance conferred by metallo-β-lactamases in Enterobacteriaceae?

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY; Lugar: Washington; Año: 2017 vol. 61

ROGER, MAGALI; SCIARA, GIULIANO; BIASO, FRÉDÉRIC; LOJOU, ELISABETH; WANG, XIE; BAUZAN, MARIELLE; GIUDICI-ORTICONI, MARIE-THÉRÈSE; VILA, ALEJANDRO J.; ILBERT, MARIANNE

Impact of copper ligand mutations on a cupredoxin with a green copper center

BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS; Año: 2017 vol. 1858 p. 351 - 359

SAIZ, CECILIA; VILLAMIL, VALENTINA; GONZÁLEZ, MARIANO M.; ROSSI, MA. AGUSTINA; MARTÍNEZ, LORENA; SUESCUN, LEOPOLDO; VILA, ALEJANDRO J.; MAHLER, GRACIELA

Enantioselective synthesis of new oxazolidinylthiazolidines as enzyme inhibitors

TETRAHEDRON-ASYMMETRY; Año: 2017 vol. 28 p. 110 - 117

LISA, MARIÁ-NATALIA; PALACIOS, ANTONELA R.; AITHA, MAHESH; GONZÁLEZ, MARIANO M.; MORENO, DIEGO M.; CROWDER, MICHAEL W.; BONOMO, ROBERT A.; SPENCER, JAMES; TIERNEY, DAVID L.; LLARRULL, LETICIA I.; VILA, ALEJANDRO J.

A general reaction mechanism for carbapenem hydrolysis by mononuclear and binuclear metallo-β-lactamases

NATURE COMMUNICATIONS; Año: 2017 vol. 8

MOJICA, MARIA F.; PAPP-WALLACE, KRISZTINA M.; TARACILA, MAGDALENA A.; BARNES, MELISSA D.; RUTTER, JOSEPH D.; JACOBS, MICHAEL R.; LIPUMA, JOHN J.; WALSH, THOMAS J.; VILA, ALEJANDRO J.; BONOMO, ROBERT A.

Avibactam restores the susceptibility of clinical isolates of Stenotrophomonas maltophilia to aztreonam

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY; Año: 2017 vol. 61

ALVAREZ-PAGGI, DAMIAN; ZITARE, ULISES A.; SZUSTER, JONATHAN; MORGADA, MARCOS N.; LEGUTO, ALCIDES J.; VILA, ALEJANDRO J.; MURGIDA, DANIEL H.

Tuning of Enthalpic/Entropic Parameters of a Protein Redox Center through Manipulation of the Electronic Partition Function

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY; Año: 2017 vol. 139 p. 9803 - 9806

GONZALEZ, L; BARH, GUILLERMO; NAKASHIGE; NOLAN; BONOMO, RA; VILA, ALEJANDRO JOSÉ

Membrane-anchoring stabilizes New Dehli carbapenemase NDM-1 upon zinc starvation and favors protein export into vesicles

NATURE CHEMICAL BIOLOGY; Lugar: Londres; Año: 2016

PASTERAN, F; GONZALEZ, L; ALBORNOZ, E; BARH, GUILLERMO; VILA, ALEJANDRO JOSÉ; CORSO, ALEJANDRA

Triton Hodge Test: an improved protocol of the Modified Hodge Test for enhanced detection of NDM and other carbapenemase producers

JOURNAL OF CLINICAL MICROBIOLOGY; Lugar: Washington; Año: 2016 vol. 54 p. 640 - 649

GONZÁLEZ, MARIANO M.; ABRIATA, LUCIANO A.; TOMATIS, PABLO E.; VILA, ALEJANDRO J.

Optimization of Conformational Dynamics in an Epistatic Evolutionary Trajectory

MOLECULAR BIOLOGY AND EVOLUTION; Año: 2016 vol. 33 p. 1768 - 1776

MORAN BARRIO, J; LISA, M N; LARRIEUX N; DRUSIN; A.M. VIALE; MORENO, DM; BUSCHIAZZO, A.; A. J. VILA

Crystal Structure of the Metallo-beta-Lactamase GOB in the periplasmic di-Zinc form reveals an unusual metal site

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY; Lugar: Washington; Año: 2016

PHILIP HINCHLIFFE; GONZALEZ MARIANO; MOJICA MF; GONZALEZ, J; CASTILLO, V; SAIZ C.; KOSMOPOULOU M; TOOKE; LLARRULL LI; GRACIELA MAHLER; ROBERT A. BONOMO; JAMES SPENCER; A.J. VILA

Cross-class metallo beta-lactamase inhibition by bisthiazolidines reveals multiple binding modes

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA; Lugar: Washington DC, USA; Año: 2016

GONZALEZ, L; BARH, GUILLERMO; A. J. VILA

Lipidated beta-lactamases: from bench to bedside

FUTURE MICROBIOLOGY; Lugar: Londres; Año: 2016

U.ZITARE; D.ÁLVAREZ-PAGGI; MORGADA, MARCOS; ABRIATA LA; A. J. VILA; MURGIDA, D

Reversible Switching of Redox Active Molecular Orbitals and Electron Transfer Pathways in CuA Sites

Angewandte Chemie International Edition; Año: 2015

MOJICA MF; MAHLER SG; BETHEL CR; TARACILA MA; KOSMOPOULOU M; PAPP-WALLACE K; LLARRULL LI; WILSON BM.; MARSHALL SH; WALLACE CJ; VILLEGAS MV; HARRIS ME; A. J. VILA; SPENCER, J.; BONOMO, RA

Exploring the Role of Residue 228 for Substrate and Inhibitor Recognition by VIM Metallo -β-Lactamases

BIOCHEMISTRY; Lugar: Washington; Año: 2015 vol. 54 p. 3183 - 3196

MEINI, MARÍA-ROCÍO; LLARRULL, LETICIA I.; VILA, ALEJANDRO J.

Overcoming differences: The catalytic mechanism of metallo-β-lactamases

FEBS LETTERS; Año: 2015 vol. 589 p. 3419 - 3432

MARIANO M. GONZÁLEZ; MAGDA KOSMOPOULOU; MARIA F. MOJICA; VALERIE CASTILLO; PHILIP HINCHLIFFE; ILARIA PETTINATI, ; JÜRGEN BREM ; CHRISTOPHER J. SCHOFIELD; GRACIELA MAHLER; ROBERT A. BONOMO; LLARRULL LI; JAMES SPENCER; ALEJANDRO J. VILA

Bisthiazolidines: a substrate-mimicking scaffold as an inhibitor of the NDM-1 carbapenemase

ACS Infectious Diseases; Año: 2015

MARÍA-ROCÍO MEINI; PABLO E TOMATIS; D. M. WEINREICH; A. J. VILA

Quantitative Description of a Protein Fitness Landscape Based on Molecular Features

MOLECULAR BIOLOGY AND EVOLUTION; Lugar: Oxford; Año: 2015 vol. 32 p. 1774 - 1787

U.ZITARE; D.ÁLVAREZ-PAGGI; MORGADA, MARCOS; ABRIATA LA; A. J. VILA; MURGIDA, D

Reversible Switching of Redox Active Molecular Orbitals and Electron Transfer Pathways in CuA Sites

Angewandte Chemie International Edition; Año: 2015

MARÍA-ROCÍO MEINI; LLARRULL, L; A. J. VILA

Evolution of Metallo-beta-lactamases: Trends Revealed by Natural Diversity and in vitro Evolution

Antibiotics; Lugar: Basel; Año: 2014

F. PEREZ; A.M. HUJER; S.H. MARSHALL; A.J. RAY; P.N. RATHER; N.SUWANTARAN; D. DUMFORD; P. O?SHEA; R.A. SALATA; B.N. KREISWIRTH; A. J. VILA; M.R. JACOBS ; R.A. BONOMO

Extensively Drug Resistant (XDR) Pseudomonas aeruginosa Containing blaVIM-2 and Elements of Salmonella Genomic Island 2: A New Genetic Resistance Determinant in Northeast Ohio

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY; Lugar: Washington; Año: 2014 vol. 58 p. 5929 - 5935

MORGADA, MARCOS; ABRIATA LA; ZITARE, U; ALVAREZ PAGGI, D; MURGIDA, D; A. J. VILA

Control of the electronic ground state on an electron transfer copper site by second-sphere perturbations

Angewandte Chemie; Lugar: Weinheim; Año: 2014

ABRIATA LA; PONTEL L.B.; A. J. VILA; DAL PERARO, M; SONCINI, F

A dimerization interface mediated by functionally critical residues creates interfacial disulfide bonds and copper sites in CueP

JOURNAL OF INORGANIC BIOCHEMISTRY; Lugar: Amsterdam; Año: 2014

ABRIATA LA; A. J. VILA; DAL PERARO M

Molecular dynamics simulations of apocupredoxins: insights into the formation and stabilization of entatic copper sites

JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY; Lugar: Berlin; Año: 2014 vol. 132 p. 18 - 20

GONZALEZ, L; MORENO, DM; BONOMO, RA; A. J. VILA

Host-specific enzyme-substrate interactions in SPM-1 metallo-β-lactamase are modulated by second sphere residues

PLOS PATHOGENS; Lugar: San Francisco; Año: 2014 vol. 10 p. 1 - 12

ABRIATA LA; A. J. VILA

Redox-state sensing by hydrogen bonds in the CuA center of cytochrome c oxidase

JOURNAL OF INORGANIC BIOCHEMISTRY; Lugar: Amsterdam; Año: 2014 vol. 132 p. 18 - 20

MARÍA-ROCÍO MEINI; LLARRULL, L; A. J. VILA

Evolution of Metallo-beta-lactamases: Trends Revealed by Natural Diversity and in vitro Evolution

Antibiotics; Lugar: Basel; Año: 2014

MARCHIARO, P; BRAMBILLA, L; MORAN BARRIO, J; REVALE, S; PASTERAN, F; A. J. VILA; A.M. VIALE; A.S.LIMANSKY

The complete nucleotide sequence of the carbapenem resistance-conferring conjugative plasmid pLD209 from a Pseudomonas putida clinical strain revealed a chimeric design formed by modules derived from both environmental and clinical bacteria

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY; Lugar: Washington; Año: 2014 vol. 58 p. 1816 - 1821

MARÍA-ROCÍO MEINI; GONZALEZ, L; A. J. VILA

Antibiotic resistance in zinc-deficient environments: Metallo-beta-lactamase activation in the periplasm

FUTURE MICROBIOLOGY; Lugar: Londres; Año: 2013 vol. 8 p. 947 - 979

ALVAREZ PAGGI, D; ABRIATA LA; MURGIDA, D; A. J. VILA

Native CuA Redox Sites are Largely Resilient to pH Variations within Physiological Range

CHEMICAL COMMUNICATIONS; Lugar: CAMBRIDGE; Año: 2013 vol. 49 p. 5381 - 5383

MARÍA-ROCÍO MEINI; GONZALEZ, L; A. J. VILA

Antibiotic resistance in zinc-deficient environments: Metallo-beta-lactamase activation in the periplasm

FUTURE MICROBIOLOGY; Lugar: Londres; Año: 2013 vol. 8 p. 1 - 3

ABRIATA LA; M.E. ZABALLA; R.E. BERRY; F. YANG; H. ZHANG; F.A.WALKER; AJ. VILA

Electron Spin Density on the Axial His Ligand of High-Spin and Low-Spin Nitrophorin 2 Probed by Heteronuclear NMR Spectroscopy

INORGANIC CHEMISTRY; Lugar: Washington; Año: 2013 vol. 52 p. 1285 - 1295

ALVAREZ PAGGI, D; ABRIATA LA; MURGIDA, D; A.J. VILA

Native CuA Redox Sites are Largely Resilient to pH Variations within Physiological Range

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS; Lugar: CAMBRIDGE; Año: 2013 vol. 49 p. 5381 - 5383

SGRIGNANI J; MAGISTRATO A; DAL PERARO M; VILA, AJ; CARLONI P; PIERATTELLI R

On the active site of mononuclear B1 metallo beta-lactamases: a computational study.

JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN; Lugar: Berlin; Año: 2012 vol. 26 p. 425 - 435

L.J. GONZÁLEZ; A. J. VILA

Carbapenem resistance in Elizabethkingia meningoseptica is mediated by metallo-beta-lactamase BlaB.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY; Lugar: Washington; Año: 2012 vol. 56 p. 1686 - 1692

BREECE RM; LLARRULL LI; TIONI MF; A. J. VILA; TIERNEY DL

X-ray absorption spectroscopy of metal site speciation in the metallo-beta-lactamase BcII from Bacillus cereus.

JOURNAL OF INORGANIC BIOCHEMISTRY; Lugar: Amsterdam; Año: 2012 vol. 111 p. 182 - 186

ABRIATA LA; ALVAREZ PAGGI, D; LEDESMA, GN; BLACKBURN, N.J; VILA, AJ; MURGIDA, D

Alternative ground states enable pathway switching in biological electron transfer

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA; Lugar: Washington DC, USA; Año: 2012 vol. 109 p. 17348 - 17353

ZABALLA ME; ABRIATA LA; DONAIRE A; VILA AJ

Flexibility of the metal-binding region in apo-cupredoxins.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA; Lugar: Washington DC, USA; Año: 2012 vol. 109 p. 9254 - 9259

LANCASTER KM; ZABALLA ME; SPROULES S; SUNDARARAJAN M; DEBEER S; RICHARDS JH; VILA AJ; NEESE F; GRAY HB

Outer-sphere contributions to the electronic structure of type zero copper proteins.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY; Lugar: Washington; Año: 2012 vol. 134 p. 8241 - 8253

LISA, M N; J. MORÁN-BARRIO; GUINDÓN, MF; A. J. VILA

Probing the role of Met221 in the unusual metallo-lactamase GOB-18

INORGANIC CHEMISTRY; Lugar: Washington; Año: 2012 vol. 51 p. 12419 - 12425

M.N. LISA; J. MORÁN-BARRIO; A. J. VILA

In vivo impact of Met221 substitution in GOB metallo-beta-lactamase

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY; Lugar: Washington; Año: 2012 vol. 56 p. 1769 - 1773

JAVIER M GONZÁLEZ; MARÍA-ROCÍO MEINI; PABLO E TOMATIS; FRANCISCO J MEDRANO MARTÍN; JULIA A CRICCO; ALEJANDRO J VILA

Metallo-beta-lactamases withstand low Zn(II) conditions by tuning metal-ligand interactions.

NATURE CHEMICAL BIOLOGY; Lugar: Londres; Año: 2012 vol. 8 p. 698 - 700

MARCHIARO P; VIALE AM; BALLERINI V,; ROSSIGNOL G; VILA AJ; LIMANSKY A

First report of a Tn402-like class 1 integron carrying blaVIM-2 in Pseudomonas putida from Argentina

The Journal of Infection in Developing Countries; Lugar: Alghero; Año: 2010 vol. 30 p. 412 - 416

MARÍA-EUGENIA ZABALLA; LYNN ZIEGLER; DAN KOSMAN ; ALEJANDRO J, VILA

NMR study of the exchange coupling in the trinuclear cluster of the multicopper oxidase Fet3p

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY; Lugar: Washington; Año: 2010 vol. 132 p. 11191 - 11196

MARIANO A. MARTINEZ; MARÍA-EUGENIA ZABALLA; FRANCIS SCHAEFFER; MARCO BELLINZONI; DANIELA ALBANESI; GUSTAVO E. SCHUJMAN; ALEJANDRO J. VILA; PEDRO M. ALZARI; DIEGO DE MENDOZA

A Novel Role of Malonyl-ACP in Lipid Homeostasis

BIOCHEMISTRY; Lugar: Washington; Año: 2010 vol. 49 p. 3161 - 3167

F.QUIÑONES-FALCONI; M. GALICIA-VELASCO; P.MARCHIARO ; V. BALLERINI; M. MUSSI; A. J. VILA; A.M. VIALE; K. BERMEJO-MORALES; A.S.LIMANSKY

Emergence of Pseudomonas aeruginosa Strains Producing Metallo-beta-lactamases of the IMP-15 and VIM-2 types in Mexico

CLINICAL MICROBIOLOGY AND INFECTION; Lugar: New York; Año: 2010 vol. 16 p. 126 - 131

V.A. CAMPOS; J.M. GONZALEZ; D.L. TIERNEY; A.J. VILA

Spectroscopic Signature of a Ubiquitous Metal Binding Site in the Metallo-beta-Lactamase Superfamily

JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY; Lugar: Heidelberg; Año: 2010 vol. 15 p. 1209 - 1218

VALERIA A. CAMPOS-BERMUDEZ; JORGELINA MORÁN-BARRIO; ANTONIO J. COSTA-FILHO; A.J.VILA

Metal-dependent inhibition of glyoxalase II: A possible mechanism to regulate the enzyme activity

JOURNAL OF INORGANIC BIOCHEMISTRY; Lugar: New York; Año: 2010 vol. 104 p. 726 - 731

MARÍA NATALIA LISA ; LARS HEMMINGSEN; ALEJANDRO J. VILA,

Catalytic role of the metal ion in the metallo-beta-lactamase GOB

JOURNAL OF BIOLOGICAL CHEMISTRY; Lugar: Bethesda; Año: 2010 vol. 285 p. 4570 - 4577

J.M. GONZALEZ; BUSCHIAZZO, A.; A. J. VILA

Evidence of adaptability in metal coordination geometry and active-site loop conformation among B1 metallo-beta-lactamases

BIOCHEMISTRY; Lugar: Washington; Año: 2010 vol. 49 p. 7930 - 7938

MARCHIARO P; VIALE AM; BALLERINI V,; ROSSIGNOL G; VILA AJ; LIMANSKY A

First report of a Tn402-like class 1 integron carrying blaVIM-2 in Pseudomonas putida from Argentina

The Journal of Infection in Developing Countries; Lugar: Alghero; Año: 2010 vol. 30 p. 412 - 416

F.SIMONA; A. MAGISTRATO; M.DAL PERARO; A. CAVALLI; P. CARLONI; A. J. VILA

Common Mechanistic Features among Metallo-beta-lactamases A COMPUTATIONAL STUDY OF AEROMONAS HYDROPHILA CphA ENZYME

JOURNAL OF BIOLOGICAL CHEMISTRY; Año: 2009 vol. 284 p. 28164 - 28171

A.ABRIATA; A. CASSINA; V. TORTORA; M. MARIN; J.SOUZA; L. CASTRO; A. J. VILA; R.RADI

Nitration of Solvent-Exposed Tyrosine(s) on Cytochrome c Triggers Heme Iron-Methionine-80 Bond Disruption: Nuclear Magnetic Resonance and Optical Spectroscopy Studies

JOURNAL OF BIOLOGICAL CHEMISTRY; Año: 2009 vol. 284 p. 17 - 26

ABRIATA LA,; LEDESMA GN; PIERATTELLI R; VILA AJ

Electronic structure of the ground and excited states of the Cu(A) site by NMR spectroscopy

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY; Lugar: USA; Año: 2009 vol. 131 p. 1939 - 1946

ABRIATA, LA; BANCI, L; BERTINI, I; CIOFI-BAFFONI, S; GKAZONIS, P; SPYROULIAS, G; VILA, AJ; WANG, S

Mechanism of CuA assembly

NATURE CHEMICAL BIOLOGY; Lugar: Washington, USA; Año: 2008 vol. 4 p. 599 - 601

TIONI, M; LLARRULL, L; POEYLAUT, A; MARTI, M; SAGGU, M; PERYANNAN, G; MATA, E; BENNET, B; MURGIDA, D; VILA, A J

Trapping and Characterization of a Reaction Intermediate in Imipenem Hydrolysis by B. cereus Metallo-beta-lactamase

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY; Lugar: Washington, USA; Año: 2008 vol. 130 p. 15852 - 15863

LLARRULL, L; TIONI, M; VILA, AJ

Metal Content and Localization during Turnover in B.cereus Metallo-beta-Lactamase

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY; Lugar: Washington, USA; Año: 2008 vol. 130 p. 15842 - 15851

ABRIATA LA; GONZALEZ, L; LLARRULL, L; TOMATIS, P; MAYERS, W; COSTELLO, A; TIERNEY, D; VILA, AJ

Engineered mononuclear variants in Bacillus cereus metallo-ß-lactamase BcII are inactive

BIOCHEMISTRY; Lugar: Washington, USA; Año: 2008 vol. 47 p. 8590 - 8599

TOMATIS, P E; FABIANE, S M; SIMONA, F.; CARLONI, P; SUTTON, B J; VILA, A J

Adaptive protein evolution grants organismal fitness by improving catalysis and flexibility

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA; Lugar: Washington, USA; Año: 2008 vol. 105 p. 20605 - 20610

MARCHIARO, P; TOMATIS, P E; MUSSI, M A; PASTERAN, F; VIALE, A M; LIMANSKY, A S; VILA, A J

Biochemical characterization of metallo-beta-lactamase VIM-11 from a Pseudomonas aeruginosa clinical strain

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY; Lugar: Washington; Año: 2008 vol. 52 p. 2250 - 2252

MARCHIARO, P; BALLERINI, V; SPALDING, T; CERA, G; MUSSI, M A; MORAN BARRIO, J; VILA, A J; VIALE, A M; LIMANSKY, A S

A convenient microbiological assay employing cell-free extracts for the rapid characterization of Gram-negative carbapenemase producers

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY; Lugar: Washington; Año: 2008 vol. 62 p. 336 - 344

ABRIATA, LA; BANCI, L; BERTINI, I; CIOFI-BAFFONI, S; GKAZONIS, P; SPYROULIAS, G; VILA, AJ; WANG, S

Mechanism of CuA assembly

Nature Chemical Biology; Lugar: Washington, USA; Año: 2008 vol. 4 p. 599 - 601

SIMONA, F.; MAGISTRATO, A.; VERA, M.; GARAU, G.; VILA, A J; CARLONI, P

Protonation state and substrate binding to B2 metallo-beta-lactamase CphA from Aeromonas hydrophila

PROTEINS: STRUCTURE, FUNCTION AND GENETICS; Lugar: United States; Año: 2007 vol. 69 p. 595 - 605

POEYLAUT, A; TOMATIS, P E; KARSISIOTIS, A; DAMBLON, C; MATA, E; VILA, A J

A Minimalistic Approach to Identify Substrate Binding Features in B1 Metallo?beta?Lactamases

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS; Lugar: England; Año: 2007 vol. 17 p. 5171 - 5174

LEDESMA, GN; MURGIDA, D; KHOA LY, H; WACKERBARTH, H; ULSTRUP, J; COSTA-FILHO, A; VILA, AJ

The Met axial ligand determines the redox potential in CuA Sites

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY; Lugar: United States; Año: 2007 vol. 129 p. 11884 - 11885

DAL PERARO, M; VILA, AJ; CARLONI, P; KLEIN, M.

Role of zinc content on the catalytic efficiency of B1 metallo-beta-lactamases

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY; Lugar: Columbus, OH, Estados Unidos; Año: 2007 vol. 129 p. 2808 - 2816

CAMPOS BERMUDEZ, V; LEITE, N; KROG, R; COSTA-FILHO, A; SONCINI, F; OLIVA, G; VILA, AJ

Biochemical and Structural Characterization of Salmonella typhimurium glyoxalase II: New insights in metal ion selectivity

BIOCHEMISTRY; Lugar: United States; Año: 2007 vol. 46 p. 11069 - 11079

GONZALEZ, J; MEDRANO MARTIN, F; COSTELLO, A; TIERNEY, D; VILA, AJ

The Zn2 Position in Metallo-beta-Lactamases is Critical for Activity: A study on Chimeric Metal Sites on a Conserved Protein Scaffold

JOURNAL OF MOLECULAR BIOLOGY; Lugar: England; Año: 2007 vol. 373 p. 1141 - 1156

LLARRULL, L; FABIANE, S; KOWALSKI, J; BENNET, B; SUTTON, B J; VILA, AJ

Asp120 locates Zn2 for optimal Metallo-beta-Lactamase Activity

JOURNAL OF BIOLOGICAL CHEMISTRY; Lugar: United States; Año: 2007 vol. 282 p. 18276 - 18285

LLARRULL, L; TIONI, M; KOWALSKI, J; BENNET, B; VILA, A.J.

Evidence for a dinuclear active site in the metallo-beta-lactamase BcII with substoichiometric Co(II): a new mechanism for Co(II) uptake

JOURNAL OF BIOLOGICAL CHEMISTRY; Lugar: United States; Año: 2007 vol. 282 p. 30586 - 30595

MORAN BARRIO, J; GONZALEZ, J; LISA, M N; COSTELLO, A; DAL PERARO, M; CARLONI, P; BENNET, B; TIERNEY, D; LIMANSKY, A S; VIALE, A M; VILA, A J

The Metallo-beta-lactamase GOB is a mono-Zn(II) enzyme with a novel active site

JOURNAL OF BIOLOGICAL CHEMISTRY; Lugar: United States; Año: 2007 vol. 282 p. 18286 - 18293

SCHUJMAN, G.; GUERIN, M.; BUSCHIAZZO, A.; SCHAEFFER, F.; LLARRULL, L; VILA, A.J.; ALZARI, P.; DE MENDOZA, D

Structural basis of lipid biosynthesis regulation in Gram-positive bacteria

EMBO JOURNAL; Año: 2006 vol. 25 p. 4047 - 4083

CROWDER, M.; SPENCER, J.; VILA, AJ

Metallo-beta-lactamases: novel weaponry for antibiotic resistance in bacteria.

ACCOUNTS OF CHEMICAL RESEARCH; Lugar: Washington DC, USA; Año: 2006 vol. 39 p. 721 - 728

MARCHIARO, P; MUSSI, M A; BALLERINI, V; PASTERAN, F; VIALE, A M; VILA, A J; LIMANSKY, A S

Sensitive EDTA-based microbiological assays for detection of metallo-{beta}-lactamases in nonfermentative gram-negative bacteria.

JOURNAL OF CLINICAL MICROBIOLOGY; Lugar: Estados Unidos; Año: 2005 vol. 43 p. 5648 - 5652

TOMATIS, P E; RASIA, R M; SEGOVIA, L; VILA, A J

Mimicking natural evolution in metallo-beta-lactamases through second-shell ligand mutations.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA; Lugar: Estados Unidos; Año: 2005 vol. 102 p. 13761 - 13766

DAVIES, A M; RASIA, R M; VILA, A J; SUTTON, B J; FABIANE, S M

Effect of pH on the active site of an Arg121Cys mutant of the metallo-beta-lactamase from Bacillus cereus: implications for the enzyme mechanism

BIOCHEMISTRY; Año: 2005 vol. 44 p. 4841 - 4849

BATTISTUZZI, G; BELLEI, M; LEONARDI, A; PIERATTELLI, R; DE CANDIA, A; VILA, AJ ; SOLA, M

Reduction thermodynamics of the T1 Cu site in plant and fungal laccases.

JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY; Lugar: Springer Berlin / Heidelberg; Año: 2005 vol. 10 p. 867 - 873

DAL PERARO, M; VILA, AJ; CARLONI, P

Substrate binding to mononuclear metallo-beta-lactamase from Bacillus cereus

PROTEINS: STRUCTURE, FUNCTION AND GENETICS; Año: 2004 vol. 54 p. 412 - 423

RASIA, R M; VILA, A J

Structural determinants of substrate binding to Bacillus cereus metallo-beta-lactamase

JOURNAL OF BIOLOGICAL CHEMISTRY; Año: 2004 vol. 279 p. 26046 - 26051

DAL PERARO, M; LLARRULL, L; ROTHLISBERGER, U; VILA, AJ; CARLONI, P

Water-assisted reaction mechanism of monozinc beta-lactamases

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY; Año: 2004 vol. 126 p. 12661 - 12668

RASIA, R M; CEOLIN, M; VILA, A J

Grafting a new metal ligand in the cocatalytic site of B. cereus metallo-beta-lactamase: structural flexibility without loss of activity

PROTEIN SCIENCE; Año: 2003 vol. 12 p. 1538 - 1546

RASIA, R M; VILA, A J

Mechanistic study of the hydrolysis of nitrocefin mediated by B.cereus metallo-beta-lactamase

Arkivoc; Año: 2003 vol. X p. 507 - 516

FERNANDEZ, C O; NIZZEKI, T; KOHZUMA, T; VILA, AJ

Metal-ligand interactions in perturbed blue copper sites: a paramagnetic (1)H NMR study of Co(II)-pseudoazurin

JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY; Año: 2003 vol. 8 p. 75 - 82

DAL PERARO, M; VILA, AJ; CARLONI, P

Protonation state of Asp120 in the binuclear active site of the metallo-beta-lactamase from Bacteroides fragilis.

INORGANIC CHEMISTRY; Año: 2003 vol. 42 p. 4245 - 4247

FERNANDEZ, C O; NIZZEKI, T; KOHZUMA, T; VILA, AJ

Metal-ligand interactions in perturbed blue copper sites: a paramagnetic (1)H NMR study of Co(II)-pseudoazurin

Journal Biological Inorganic Chemistry; Año: 2003 vol. 8 p. 75 - 82

RASIA, R M; VILA, A J

Mechanistic study of the hydrolysis of nitrocefin mediated by B.cereus metallo-beta-lactamase

Arkivoc; Año: 2003 vol. X p. 507 - 516

L ESTIU, G; RASIA, R M; CRICCO, J A; VILA, AJ

Is there a bridging ligand in metal-substituted beta-lactamases : A spectroscopic and theoretical answer

INTERNATIONAL JOURNAL OF QUANTUM CHEMISTRY; Año: 2002 vol. 88 p. 118 - 132

RASIA, R M; VILA, A J

Exploring the role and the binding affinity of a second zinc equivalent in B. cereus metallo-beta-lactamase.

BIOCHEMISTRY; Año: 2002 vol. 41 p. 1853 - 1860

MANSILLA, M C; DIAZ, A R; VILA, AJ; DE MENDOZA, D

Membrane topology of the acyl-lipid desaturase from Bacillus subtilis

JOURNAL OF BIOLOGICAL CHEMISTRY; Año: 2002 vol. 277 p. 48099 - 48106

DONAIRE, A; JIMENEZ, B; FERNANDEZ, C O; PIERATTELLI, R; NIIZEKI, T; MORATAL, J M; HALL, J F; KOHZUMA, T; HASNAIN, S S; VILA, AJ

Metal-ligand interplay in blue copper proteins studied by 1H NMR spectroscopy: Cu(II)-pseudoazurin and Cu(II)-rusticyanin

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY; Año: 2002 vol. 124 p. 13698 - 13708

DAL PERARO, M; VILA, AJ; CARLONI, P

Structural determinants and hydrogen-bond network of the mononuclear zinc(II)-beta-lactamase active site

JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY; Año: 2002 vol. 7 p. 704 - 712

DAL PERARO, M; VILA, AJ; CARLONI, P

Structural determinants and hydrogen-bond network of the mononuclear zinc(II)-beta-lactamase active site

Journal Of Biological Inorganic Chemistry; Año: 2002 vol. 7 p. 704 - 712

FERNANDEZ, C O; CRICCO, J A; SLUTTER, C E; RICHARDS, J H; GRAY, H B; VILA, AJ

Axial ligand modulation of the electronic structures of binuclear copper sites: analysis of paramagnetic 1H NMR spectra of Met160Gln Cu(A)

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY; Año: 2001 vol. 123 p. 11678 - 11685

BERTINI, I; CIURLI, S; DIKIY, A; FERNANDEZ, C O; LUCHINAT, C; SAFAROV, N; SHUMILIN, S; VILA, AJ

The first solution structure of a paramagnetic copper(II) protein: the case of oxidized plastocyanin from the cyanobacterium Synechocystis PCC6803

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY; Año: 2001 vol. 123 p. 2405 - 2413

BERTINI, I; BRYANT, D A; CIURLI, S; DIKIY, A; FERNANDEZ, C O; LUCHINAT, C; SAFAROV, N; VILA, AJ; ZAHO, J

Backbone dynamics of plastocyanin in both oxidation states. Solution structure of the reduced form and comparison with the oxidized state

JOURNAL OF BIOLOGICAL CHEMISTRY; Año: 2001 vol. 276 p. 47217 - 47226

BERTINI, I; FERNANDEZ, C O; LUCHINAT, C; KARISSON, B G; LECKNER, J; MALMSTRÖM, B; NERSISSIAN, A M; PIERATTELLI, R; SHIPP, E; VALENTINE, J S; VILA, A J

Structural information through NMR hyperfine shifts in blue copper proteins

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY; Año: 2000 vol. 122 p. 3701 - 3707

CRICCO, J A; VILA, A J

Class B beta-lactamases: the importance of being metallic.

CURRENT PHARMACEUTICAL DESIGN.; Año: 1999 vol. 5 p. 915 - 927

CRICCO, J A; RASIA, R M; ORELLANO, E G; CECCARELLI, E A; VILA, AJ

Metallo-b-lactamases: Does it take two to tango?

COORDINATION CHEMISTRY REVIEWS; Año: 1999 vol. 190 p. 519 - 535

ORELLANO, E G; GIRARDINI, J E; CRICCO, J A; CECCARELLI, E A; VILA, A J

Spectroscopic characterization of a binuclear metal site in Bacillus cereus beta-lactamase II.

BIOCHEMISTRY; Año: 1998 vol. 37 p. 10173 - 10180

FERNANDEZ, C O; SANNAZZARO, A I; DIAZ, L E; VILA, AJ

Probing the Metal Site in Rhus vernicifera Stellacyanin by Ni(II)-Substitution and Paramagnetic NMR Spectroscopy

INORGANICA CHIMICA ACTA; Año: 1998 vol. 273 p. 367 - 371

FERNANDEZ, C O; PODESTA, O; CONVERSO, D A; FERNANDEZ, M E; VILA, AJ

A Biophysical Characterization of the Iron Coordination Environment in Wheat Germ Peroxidase

JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY; Año: 1997 vol. 2 p. 218 - 224

FERNANDEZ, C O; SANNAZZARO, A I; VILA, AJ

Alkaline transition of Rhus vernicifera stellacyanin, an unusual blue copper protein

BIOCHEMISTRY; Año: 1997 vol. 36 p. 10566 - 10570

ALEJANDRO JOSE VILA; RAMIREZ, B E; DI BILIO, A J; MIZOGUCHI, T J; RICHARDS, J H; B GRAY, H

Paramagnetic NMR Spectroscopy of Cobalt(II) and Copper(II) Derivatives of Pseudomonas aeruginosa His46Asp Azurin.

INORGANIC CHEMISTRY; Año: 1997 vol. 36 p. 4567 - 4570

FERNANDEZ, C O; PODESTA, O; CONVERSO, D A; FERNANDEZ, M E; VILA, AJ

A Biophysical Characterization of the Iron Coordination Environment in Wheat Germ Peroxidase

Journal Of Biological Inorganic Chemistry; Año: 1997 vol. 2 p. 218 - 224

VILA, AJ; FERNANDEZ, C O

The Structure of the Metal Site in Rhus vernicifera Stellacyanin: A Paramagnetic NMR Study on its Co(II)-derivative

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY; Año: 1996 vol. 118 p. 7291 - 7298

BANCI, L; BERTINI, I; TIEN, M; PIERATTELLI, R; VILA, A J

Factoring of the Hyperfine Shifts in the Cyanide Adduct of Lignin Peroxidase from P. chrysosporium

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY; Año: 1995 vol. 117 p. 8659 - 8667

BANCI, L; BERTINI, I; PIERATTELLI, R; VILA, A J

1H-13C HETCOR Investigations on Heme-containing systems

INORGANIC CHEMISTRY; Año: 1994 vol. 33 p. 4338 - 4343

SPANEVELLO, R A; VILA, A J

7-a-Acetoxyhardwickiic Acid: A New Furanoid Clerodane

PHYTOCHEMISTRY; Año: 1994 vol. 35 p. 537 - 538

LAGIER, C M; VILA, A J; OLIVIERI, A C

Shifting of the keto-enol equilibrium in dibenzoylmethane by methyl substitution. An AM1 Study

JOURNAL OF MOLECULAR STRUCTURE; Año: 1994 vol. 309 p. 59 - 64

BERTINI, I; JONSSON, B H; LUCHINAT, C; PIERATTELLI, R; VILA, A J

Strategies of signal assignments in paramagnetic metalloproteins. An NMR investigation of the thiocyanate adduct of the cobalt (II)-substituted human carbonic anhydrase II.

JOURNAL OF MAGNETIC RESONANCE - B; Año: 1994 vol. 104 p. 230 - 239

BERTINI, I; CAPOZZI, F; LUCHINAT, C; PICCIOLI, M; ALEJANDRO JOSE VILA

The Fe4S4 Centers in Ferredoxins Studied through Proton and Carbon Hyperfine Coupling. Sequence Specific Assignments of Cysteines in Ferredoxins from Clostridium acidi urici and Clostridium pasterianum

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY; Año: 1994 vol. 116 p. 651 - 660

ALEJANDRO JOSE VILA

A 1H NMR NOE study on Co(II) stellacyanin: some clues about the structure of the metal site.

FEBS LETTERS; Año: 1994 vol. 355 p. 15 - 18

BERTINI, I; TURANO, P; ALEJANDRO JOSE VILA

NMR of Paramagnetic Metalloproteins

CHEMICAL REVIEWS.; Año: 1993 vol. 93 p. 2833 - 2932

BERTINI, I; GORI, G; LUCHINAT, C; ALEJANDRO JOSE VILA

One- and two-dimensional NMR characterization of oxidized and reduced cytochrome c'from Rhodocyclus gelatinosus

BIOCHEMISTRY; Año: 1993 vol. 32 p. 776 - 783

BANCI, L; BERTINI, I; KUAN, I C; TIEN, M; TURANO, P; ALEJANDRO JOSE VILA

NMR investigation of isotopically labeled cyanide derivatives of lignin peroxidase and manganese peroxidase.

BIOCHEMISTRY; Año: 1993 vol. 32 p. 13483 - 13489

ALEJANDRO JOSE VILA; CRAVERO, R M; GONZALEZ SIERRA, M

Stereoselective Route to Highly Functionalized 4a,8a-substituted 1,2,3,4,4a,6,8a,9, 10,10a-Decahydrophenanthrenes. A New Entry to the Quassinoid and Fusidane Frameworks

TETRAHEDRON; Año: 1993 vol. 21 p. 4511 - 4526

BERTINI, I; LUCHINAT, C; PIERATTELLI, R; ALEJANDRO JOSE VILA

The interaction of acetate and formate with cobalt carbonic anhydrase. An NMR study.

EUROPEAN JOURNAL OF BIOCHEMISTRY; Año: 1992 vol. 208 p. 607 - 615

BERTINI, I; LUCHINAT, C; PIERATTELLI, R; ALEJANDRO JOSE VILA

A Multinuclear Ligand NMR Investigation of Cyanide, Cyanate and Thiocyanate Binding to Zinc and Cobalt Carbonic Anhydrase

INORGANIC CHEMISTRY; Año: 1992 vol. 31 p. 3975 - 3979

ALEJANDRO JOSE VILA; LAGIER, C M; OLIVIERI, A C

C,O Atomic Motion Associated with Solid-State Proton Transfer in Enolic 1,3-Diketones

JOURNAL OF MOLECULAR STRUCTURE; Año: 1992 vol. 274 p. 215 - 222

ALEJANDRO JOSE VILA; CRAVERO, R M; GONZALEZ SIERRA, M

The Reductive Alkylation of Aromatic Ketones Revisited. A New Stereoselective Route to Highly Functionalized 4a,8a-substituted 1,2,3,4,4a,6,8a,9,10,10a Decahydro- phenanthrenes

TETRAHEDRON LETTERS; Año: 1991 vol. 32 p. 1929 - 1932

ALEJANDRO JOSE VILA; LAGIER, C M; OLIVIERI, A C

Proton Transfer in Solid 1-phenyl butane-1,3-dione and related 1,3-diones as studied by 13C CPMAS and AM1 Calculations

JOURNAL OF PHYSICAL CHEMISTRY; Año: 1991 vol. 95 p. 5069 - 5073

ALEJANDRO JOSE VILA; LAGIER, C M; OLIVIERI, A C; WAGNER, G

31P Solid-State NMR Spectra of Crystalline Phosphoric Acid and their Relation to the Structure of Urea Phosphate

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS; Año: 1991 p. 683 - 685

ALEJANDRO JOSE VILA; LAGIER, C M; OLIVIERI, A C

13C NMR and AM1 Study of the Intramolecular Proton Transfer in Solid 1,3-diphenyl-1,3-propanedione

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 2; Año: 1990 vol. 2 p. 1615 - 1618

ALEJANDRO JOSE VILA; LAGIER, C M; OLIVIERI, A C

High Resolution Solid-State NMR Study of Reversible 1,5 Proton Shifts in Organic Solids

MAGNETIC RESONANCE IN CHEMISTRY; Año: 1990 vol. 28 p. 1 - 1

ALEJANDRO JOSE VILA; SPANEVELLO, R A; OLIVIERI, A C; GONZALEZ SIERRA, M; MCCHESNEY, J D

Conformational Analysis of the 4a-Methyl Octahydrophenanthrene System. A Spectroscopic and Theoretical Approach

TETRAHEDRON; Año: 1989 vol. 45 p. 4951 - 4960

ALEJANDRO JOSE VILA; GONZALEZ SIERRA, M

Hydroxyl Substituent Effects on 13C NMR Spectra of 4a-Methyl Octahydrophenanthrenes

SPECTROSCOPY LETTERS; Año: 1989 vol. 22 p. 1291 - 1299