Distinct mechanisms of dissemination of NDM-1 metallo-β-lactamase in acinetobacter species in Argentina

M.D. ADAMS; PASTERAN, F; TRAGLIA, G.M.; MARTINEZ, JASMINE; HUANG, F.; LIU, CHRISTINE; FERNANDEZ, JENNIFER S.; LOPEZ, CAROLINA; GONZALEZ, LISANDRO J.; ALBORNOZ, E; CORSO, ALEJANDRA; A.J. VILA; BONOMO, ROBERT A.; RAMIREZ, MARIA SOLEDAD

Antimicrobial Agents and Chemotherapy

American Society for MicrobiologyJournals@asmusa.org

Lugar: Washington DC; Año: 2020 vol. 64 p. 1 - 6

A 4-year surveillance of carbapenem-resistant Acinetobacter spp. isolates in Argentina identified 40 strains carrying blaNDM-1. Genome sequencing revealed that most were Acinetobacter baumannii, whereas seven represented other Acinetobacter spp. The A. baumannii genomes were closely related, suggesting recent spread. blaNDM-1 was located in the chromosome of A. baumannii strains and on a plasmid in non-A. baumannii strains. A resistance gene island carrying blaPER-7 and other resistance determinants was found on a plasmid in some A. baumannii strains.