Neuroprotective effects associated to immune modulation by selected lactic acid bacteria in a Parkinson?s disease model

PEREZ-VISNUK, D.; SAVOY DE GIORI, G.; LEBLANC, JEAN GUY; DE MORENO DE LEBLANC, ALEJANDRA DE MORENO

NUTRITION

ELSEVIER SCIENCE INC

Lugar: Amsterdam; Año: 2020 vol. 79

0899-9007

Objectives: Parkinson?s Disease (PD) is a neurodegenerative process affecting motor function that involves an inflammatory response and B vitamins deficiencies. The aim of this study was to evaluate the effect of B-group vitamin producing and immunomodulatory lactic acid bacteria (LAB) in a murine model of PD. Methods: The effect of Lactobacillus plantarum CRL 2130 (a riboflavin producer), Streptococcus thermophilus CRL 807 (an immunomodulatory strain) and Streptococcus thermophilus CRL 808 (a folate producer) were evaluated individually and as a mixture in mice injected with 1-methyl-4-fenil-1,2,3,6-tetrahidropiridina (MPTP). Motor capacity, tyrosine hydrolase (TH) in brain and cytokine concentrations in serum and in brain tissues were evaluated in MPTP treated mice after bacterial supplementation. Results: Mice receiving the selected LAB showed significantly improved motor skills compared to those that did not receive bacterial supplementation. When given the mixture of all 3 strains together, animals had higher brain TH+ cell counts, decreased the inflammatory cytokines IL-6 and TNF-α in serum and increasObjectives: Parkinson?s Disease (PD) is a neurodegenerative process affecting motor function that involves an inflammatory response and B vitamins deficiencies. The aim of this study was to evaluate the effect of B-group vitamin producing and immunomodulatory lactic acid bacteria (LAB) in a murine model of PD. Methods: The effect of Lactobacillus plantarum CRL 2130 (a riboflavin producer), Streptococcus thermophilus CRL 807 (an immunomodulatory strain) and Streptococcus thermophilus CRL 808 (a folate producer) were evaluated individually and as a mixture in mice injected with 1-methyl-4-fenil-1,2,3,6-tetrahidropiridina (MPTP). Motor capacity, tyrosine hydrolase (TH) in brain and cytokine concentrations in serum and in brain tissues were evaluated in MPTP treated mice after bacterial supplementation. Results: Mice receiving the selected LAB showed significantly improved motor skills compared to those that did not receive bacterial supplementation. When given the mixture of all 3 strains together, animals had higher brain TH+ cell counts, decreased the inflammatory cytokines IL-6 and TNF-α in serum and increased the anti-inflammatory cytokine IL-10 in serum and brain tissues compared to animals that did not receive LAB supplementation. Conclusions: The results showed the potential of a selected LAB mixture to improve motor behavior and neuroinflammation in PD. This probiotic mixture could be used as an adjunct treatment in the control of PD. ed the anti-inflammatory cytokine IL-10 in serum and brain tissues compared to animals that did not receive LAB supplementation. Conclusions: The results showed the potential of a selected LAB mixture to improve motor behavior and neuroinflammation in PD. This probiotic mixture could be used as an adjunct treatment in the control of PD.