The effect of spray-drying on the protective capacity of the breastmilk derived Bifidobacterium animalis subsp. lactis INL1 on acute and chronic colitis in mice.

JIRY HRDY; JORGE REINHEIMER; CORINNE GRANGETTE; JEANNE ALARD; ROXANA PAEZ; GABRIEL VINDEROLA; PATRICIA BURNS; DENISE BOUTILLIER; BRUNO POT

Turku

Simposio; The 26th Annual BioCity Symposium "Microbes R US"; 2016

Gut microbiota dysbiosis plays a central role in the development and perpetuation of chronic inflammation in inflammatory bowel disease and therefore is key target forinterventions with well-characterized probiotics. The production of stable probiotic formulations, from locally sourced strains and using low cost technologies, will contribute to the expansion of themarket and the applications of probiotic bacteria, specially in developing countries. Freeze drying has been the main form of drying probiotics for application in foods and supplements. Spray drying is alow-cost alternative to freeze drying because it is relatively inexpensive (up to 80% costs reduction) and it allows the continuous production of large amounts of dried cells. Unfortunately, not everyprobiotic strain is resistant to this technology. The aim of this study was to compare the anti-inflammatory capacity of Bifidobacterium animalis subsp. lactis (B. lactis) INL1, a probiotic candidateisolated in Argentina from human breast milk, with the commercial strain B. animalis subsp. lactis Bb12, in a model of acute and chronic colitis in mice, and to study the effect of spray drying in 20%skim milk on their functionality