GC-MS identification of alkaloids from the genus Lycoris

GUO, YING; PIGNI, NATALIA B.; ZHENG, YUHONG; DE ANDRADE, JEAN PAULO; TORRAS-CLAVERIA, LAURA; DE SOUZA BORGES, WARLEY; VILADOMAT, FRANCESC; CODINA, CARLES; BASTIDA, JAUME

Beijing

Conferencia; 2nd International Conference and Exhibition on Pharmacognosy, Phytochemistry & Natural Products; 2014

OMICS Group Conference

The genus Lycoris, a group of Amaryllidaceae plants distributed in températe regions of Eastern Asia, is known for containing representative alkaloids typical of this botanical family with a wide range of biological activities (such as lycorine and galanthamine). The alkaloids found in Amaryllidaceae species have shown many pharmacological properties including antiprotozoal, antiviral, antitumoral, and acetylcholinesterase inhibitory activities. One of the most renowned compounds of this group is galanthamine, a drug marketed for the treatment of Alzheimer´s disease. In the present work, the species L. albiflora, L. aurea, L. chinensis, L. haywardii, L. incarnata, L. longituba, L. radiata, L. sprengeri, and L. squamigera, and one variety (L. radiata var. pumila) have been evaluated by GC-MS. Structures belonging to the lycorine-, homolycorine-, haemanthamine-, narciclasine-, tazettine-, montanine- and galanthamine-series were identified and quantified. Galanthamine- and lycorine-type alkaloids were predominating, showing a high relative abundance in comparison with other alkaloids detected in the extracts. Interestingly, L. longituba revealed itself to be a potential commercial source of bioactive alkaloids.