EDUARDO CHULUYAN; CARLOS DAVIO; NELSON DUSETTI; NICOLAS FRAUNHOFFER; MARÍA NOÉ GARCIA; JUAN GARONA; BETINA GONZÁLEZ; FLORENCIA GOTTARDO; DANIEL GRASSO; JUAN IOVANNA; GUSTAVO KOHAN; PAUL EDUARDO LADA; OSCAR MAZZA; MARTÍN MONTE; DANIELA PAPADEMETRIO; MARÍA EUGENIA PASQUALINI; ANA SAHORES; PATRICIA SANTOFIMIA; AGUSTÍN YANEFF

LA VACUNA DE ARNm PARA EL TRATAMIENTO DEL CÁNCER DE PÁNCREAS LLEGÓ PARA QUEDARSE

MEDICINA (BUENOS AIRES); Lugar: Buenos Aires; Año: 2023

HAEUBLEIN, GERALDINE; LOMBARDI, GABRIELA; CARO, FIORELLA; GUERRIERI, DIEGO; REMOLINS, CARLA; INCARDONA, CLAUDIO; CASADEI, DOMINGO; CHULUYAN, EDUARDO

Human Endothelial Cell Seeding in Partially Decellularized Kidneys

BioMed Research International; Año: 2022

FRAUNHOFFER, NICOLAS ALEJANDRO; ABUELAFIA, ANALÍA MEILERMAN; CHANEZ, BRICE; BIGONNET, MARTIN; GAYET, ODILE; ROQUES, JULIE; CHULUYAN, EDUARDO; DUSETTI, NELSON; IOVANNA, JUAN

Inhibition of glucuronidation in pancreatic cancer improves gemcitabine anticancer activity

Cancer Communications; Año: 2022

FRAUNHOFFER, NICOLAS A; ANALIA MEILERMAN ABUELAFIA; TEYSSEDOU, CARLOS; CHULUYAN, EDUARDO; BIGONNET, MARTIN; PALAZZO, LAURENT; GAYET, ODILE; NICOLLE, REMY; CROS, JEROME; IOVANNA, J; DUSETTI, NELSON

Squamousness gain defines pancreatic ductal adenocarcinoma hepatic metastases phenotype, and gemcitabine response

EUROPEAN JOURNAL OF CANCER; Lugar: Amsterdam; Año: 2021

GUERRIERI, DIEGO; AMBROSI, NELLA GABRIELA; ROMEO, HORACIO; SALABERRY, JUAN; TONIOLO, FERNANDA; REMOLINS, CARLA; INCARDONA, CLAUDIO; CASADEI, DOMINGO; CHULUYAN, EDUARDO

Secretory Leukocyte Proteinase Inhibitor Protects Acute Kidney Injury Through Immune and Non-Immune Pathways

SHOCK; Lugar: Philadelphia; Año: 2021

FRAUNHOFFER, NICOLÁS A.; CLOSA, DANIEL; FOLCH-PUY, EMMA; ABUELAFIA, ANALÍA MEILERMAN; CALVO, EZEQUIEL LUIS; CHULUYAN, EDUARDO; IOVANNA, JUAN

Targeting REG3β limits pancreatic ductal adenocarcinoma progression through CTGF downregulation

CANCER LETTERS; Año: 2021 vol. 521 p. 64 - 70

UVA, P; QUEVEDO, A; ROSÉS, J.; TONIOLO, MF; PILOTTI, R.; CHULUYAN, E.; RÉ, L.

Estado actual del trasplante renopancreático

REVISTA DE NEFROLOGIA DIALISIS Y TRASPLANTE; Lugar: Buenos Aires; Año: 2021

POTILINSKI, MARÍA CONSTANZA; ORTÍZ, GUSTAVO A.; SALICA, JUAN P.; LÓPEZ, EMILIANO S.; FERNÁNDEZ ACQUIER, MARIANO; CHULUYAN, EDUARDO; GALLO, JUAN E.

Elucidating the mechanism of action of alpha-1-antitrypsin using retinal pigment epithelium cells exposed to high glucose. Potential use in diabetic retinopathy

PLOS ONE; Año: 2020 vol. 15

FRAUNHOFFER, NICOLAS A; MEILERMAN, ANALIA; BIGONNET, MARTIN; GAYET, ODILE; ROQUE, JULIE; TELLE, EMMANUEL; SANTOFIMIA-CASTAÑO, PATRICIA; BORRELLO, MARIA TERESA; CHULUYAN, EDUARDO; DUSETTI, NELSON; IOVANNA, JUAN

Evidencing a pancreatic ductal adenocarcinoma subpopulation sensitive to the proteasome inhibitor Carfilzomib

CLINICAL CANCER RESEARCH; Año: 2020

UVA, PABLO DANIEL; QUEVEDO, ALEJANDRA; ROSES, JOSEFINA; TONIOLO, MARÍA FERNANDA; PILOTTI, ROXANA; CHULUYAN, EDUARDO; CASADEI, DOMINGO H.

Anti‐Hla donor‐specific antibody monitoring in pancreas transplantation: Role of protocol biopsies

CLINICAL TRANSPLANTATION; Año: 2020

REMOLINS, CARLA; CHULUYAN, EDUARDO

La investigación biomédica no-SARS-CoV-2 en tiempos de pandemia y post-pandemia

MEDICINA (BUENOS AIRES); Lugar: Buenos Aires; Año: 2020

CHULUYAN, E.; CASADEI, D; AMBROSI, N; CARO, F; GUERRIERI, D.

The Role of Secretory Leukocyte Proteinase Inhibitor During Transplantation

Current Transplantation Reports; Año: 2019

AMBROSI, N; CARO, F; OSELLA, F.; DIAZ-ALVAREZ, L.; SÁNCHEZ, F; TONIOLO, F; GUERRIERI, D.; INCARDONA, C.; CASADEI, D.; CHULUYAN, E.

Secretory Leukocyte Proteinase Inhibitor In The Perfusion Solution Helps To Identify Graft Quality In Kidney Transplants

BIOMARKERS IN MEDICINE; Lugar: Londres; Año: 2019

CASCIATO, PAOLA; AMBROSI, NELLA; CARO, FIORELLA; VAZQUEZ, MÓNICA; MÜLLEN, EDUARDO; GADANO, ADRIAN; DE SANTIBAÑES, EDUARDO; DE SANTIBAÑES, MARTÍN; ZANDOMENI, MARCOS; CHAHDI, MAGALI; LAZARTE, JULIO C.; BIAGIOLA, DAVID A.; IAQUINANDI, JUAN CRUZ; SANTOFIMIA-CASTAÑO, PATRICIA; IOVANNA, JUAN; INCARDONA, CLAUDIO; CHULUYAN, EDUARDO

α-lipoic acid reduces postreperfusion syndrome in human liver transplantation - a pilot study

TRANSPLANT INTERNATIONAL; Año: 2018

MAFFÍA, PAULO C.; GUERRIERI, DIEGO; VILLALONGA, XIMENA; CARO, FIORELLA; GÓMEZ, SONIA; TATEOSIAN, NANCY; BOGADO, BETIANA P.; SÁNCHEZ, MERCEDES L.; AMBROSI, NELLA; CHULUYAN, EDUARDO

Cementoin–SLPI fusion protein binds to human monocytes and epithelial cells and shows higher biological activity than SLPI

Scientific Reports; Lugar: Londres; Año: 2018 vol. 8

ORTIZ, GUSTAVO; LOPEZ, EMILIANO S.; SALICA, JUAN P.; POTILINSKI, CONSTANZA; FERNÁNDEZ ACQUIER, MARIANO; CHULUYAN, EDUARDO; GALLO, JUAN E.

Alpha-1-antitrypsin ameliorates inflammation and neurodegeneration in the diabetic mouse retina

EXPERIMENTAL EYE RESEARCH; Año: 2018 vol. 174 p. 29 - 39

AMBROSI, NELLA; GUERRIERI, DIEGO; CARO, FIORELLA; SANCHEZ, FRANCISCO; HAEUBLEIN, GERALDINE; CASADEI, DOMINGO; INCARDONA, CLAUDIO; CHULUYAN, EDUARDO

Alpha Lipoic Acid: A Therapeutic Strategy that Tend to Limit the Action of Free Radicals in Transplantation

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES; Año: 2018 vol. 19

NICOLAS ALEJANDRO FRAUNHOFFER; ANALIA MEILERMAN ABUELAFIA; MARIANGEL AQUINO BARRIENTOS; KAREN VERONICA CIMERMAN; MARIA FLORENCIA OLMOS; EDUARDO CHULUYAN; MARCELA BARRIOS

Long-term apoptosis-related protein expression in the diabetic mouse ovary

PLOS ONE; Lugar: San Francisco; Año: 2018

UVA, P D; PAPADIMITRIOU, J C; DRACHENBERG, C B; TONIOLO, F; QUEVEDO, A; DOTTA, A C; CHULUYAN, E; CASADEI, D H

Graft dysfunction in simultaneous pancreas kidney transplantation (spk): results of concurrent kidney and pancreas allograft biopsies

AMERICAN JOURNAL OF TRANSPLANTATION; Lugar: Londres; Año: 2018

UVA, PABLO; ODORICO, J; GIUNIPPERO, ALEJANDRO; CABRERA, IGNACIO; GALLO, ANTONIO; LEÓN, LUIS; MINUÉ, ELENA; TONIOLO, MARÍA; PILOTTI, ROXANA; GONZALEZ, IGNACIO; CHULUYAN, EDUARDO; CASADEI, DOMINGO

LAPAROSCOPIC BIOPSIES IN PANCREAS TRANSPLANTATION

AMERICAN JOURNAL OF TRANSPLANTATION; Lugar: Londres; Año: 2017

LONCLE, C; BONNIOCH, L; FOLCH-PUY, E; LOPEZ-MILLAN, MB; LAC, S; MOLEJON, MI; CHULUYAN, E.; CORDELIER, P; DUBUS, P; LOMBERK, G; URRUTIA, R; CLOSA, D; IOVANNA, J

REG3β Plays a Key Role in IL17RA Protumoral Effect-Response

CANCER RESEARCH; Lugar: Philadelphia; Año: 2016

LEÓN, LUIS; UVA, PABLO; MINUÉ, ELENA; PILOTTI, ROXANA; CABRERA, IGNACIO; GIUNIPPERO, ALEJANDRO; GALLO, ANTONIO; OSELLA, FRANCISCO; TONIOLO, FERNANDA; CHULUYAN, EDUARDO; CASADEI, DOMINGO

Successfull Simultaneous Pancreas Kidney transplantation in a patient with Congenital Partial Lipodystrophy

NEFROLOGIA; Lugar: Madrid; Año: 2016

AMBROSI,N; ARROSAGARAY, V; GUERRIERI, D; UVA, P; PETRONI, J; BUONPENSIERE HERRERA, M; IOVANNA, J; LEÓN, LUIS; INCARDONA, C; CHULUYAN, HE.; CASADEI, D

α-Lipoic Acid Protects Against Ischemia-Reperfusion Injury in Simultaneous Kidney-Pancreas Transplantation.

TRANSPLANTATION; Lugar: Philadelphia; Año: 2016

AMBROSI, N; GUERRIERI, D; CARO, F; BARBIERI KENNEDY, B; SANCHEZ, F; SANCHEZ, M; CHULUYAN, HE

SLPI (secretory leukocyte peptidase inhibitor)

Atlas of Genetics and Cytogenetics in Oncology and Haematology; Lugar: Poitiers; Año: 2016 p. 331 - 340

SALVATIERRA, E; ALVAREZ, MJ; LEISHMAN, CC; RIVAS BAQUERO, E; LUTZKY, V; CHULUYAN, HE; PODHAJCER, OL

SPARC Controls Melanoma Cell Plasticity through Rac1

PLOS ONE; Lugar: San Francisco; Año: 2015

SALICA JP; GUERRIERI D; MAFFIA PC; CROXATTO JO; CHULUYAN HE; GALLO JE

Transglutaminase binding fusion protein linked to SLPI reduced corneal inflammation and neovascularization.

BMC ophthalmology; Año: 2015

CHULUYAN, HE; GUERRIERI, D; AMBROSI, N; CARO, F

Complemento y Trasplante de órganos

Revista Argentina de Trasplantes; Lugar: CABA; Año: 2015 vol. 7 p. 102 - 121

LONCLE, C; BONNIOCH, L; FOLCH-PUY, E; LOPEZ-MILLAN, MB; LAC, S; MOLEJON, MI; CHULUYAN, E; CORDELIER, P; DUBUS, P ; LOMBERK, G; URRUTIA, R; CLOSA, D ; IOVANNA, J

IL17 Functions through the Novel REG3β-JAK2-STAT3 Inflammatory Pathway to Promote the Transition from Chronic Pancreatitis to Pancreatic Cancer

CANCER RESEARCH; Lugar: Philadelphia; Año: 2015 vol. 15 p. 4852 - 4862

PEÑA, D; ROVETTA, A; HERNANDEZ DEL PINO, RE; AMIANO, N; PASQUINELLI, V; PELLEGRINO, JM; TATEOSIAN, N; ROLANDELLI, A; GUTIERREZ M; MUSELLA RM; PALMERO DJ; GHERARDI MM; IOVANNA J; CHULUYAN, HE; GARCÍA, VERÓNICA E.

Mycobacterium tuberculosis Dormancy Antigen Differentiates Latently Infected Bacillus Calmette-Guérin-vaccinated Individuals

EBioMedicine; Lugar: Amsterdam; Año: 2015 vol. 30 p. 882 - 888

ORTIZ G; SALICA JP; CHULUYAN EH; GALLO JE

Diabetic retinopathy: could the alpha-1 antitrypsin be a therapeutic option?

BIOLOGICAL RESEARCH; Lugar: Santiago de Chile; Año: 2014

TATEOSIAN NL, PASQUINELLI V, AMBROSI N, GUERRIERI D, HERNÁNDEZ DEL PINO R, SIGIFREDO P, SANTUCCI N, D´ATTILIO L, PELLEGRINI J, ARAUJO MA, MUSELLA R, PALMERO D, GARCIA V, CHULUYAN HE

The Impact of IFN-gamma; Receptor on SLPI Expression in Active Tuberculosis: Association with Disease Severity.

AMERICAN JOURNAL OF PATHOLOGY; Lugar: Bethesda ; Año: 2014 vol. 184 p. 1268 - 1273

GUERRIERI D, RE L, PETRONI J, AMBROSI N, PILOTTI RE, CHULUYAN HE, CASADEI D, INCARDONA C

Gene expression profile in delay graft function: inflammatory markers are associated with recipient and donor risk factors

MEDIATORS OF INFLAMMATION; Lugar: New York; Año: 2014

ROSSO, M; LAPYCKYJ, L.; AMIANO, N.; BESSO, MJ; SANCHEZ, M.; CHULUYAN, E.; VAZQUEZ-LEVIN, MH

SECRETORY LEUKOCYTE PROTEASE INHIBITOR (SLPI) EXPRESSION DOWNREGULATES E-CADHERIN, INDUCES -CATENIN RE-LOCALIZATION AND TRIGGERS APOPTOSIS-RELATED EVENTS IN BREAST CANCER CELLS

BIOLOGY OF THE CELL; Lugar: Londres; Año: 2014

AMIANO NO, COSTA MJ, REITERI RM, PAYÉS C, GUERRIERI D, TATEOSIAN NL, SÁNCHEZ ML, MAFFIA PC, DIAMENT M, KARAS R, ORQUEDA A, RIZZO M, ALANIZ L, MAZZOLINI G, KLEIN S, SALLENAVE JM, CHULUYAN HE.

Anti-tumor effect of SLPI on mammary but not colon tumor growth.

JOURNAL OF CELLULAR PHYSIOLOGY; Lugar: New York; Año: 2013 vol. 228 p. 469 - 475

EDUARDO CHULUYÁN, MERCEDES L. SÁNCHEZ,

SISTEMA INMUNE Y DAÑO POR INFLAMACIÓN

Ciencia e Investigación; Lugar: Buenos Aires; Año: 2013 p. 71 - 88

CICORA F; ROBERTI, J; VASQUEZ, D; GUERRIERI, D; LAUSADA, N; CICORA, P; PALTI, G; CHULUYAN, HE; GONZALEZ, P; STRINGA, P; RAIMONDI, C

Preconditioning donor with a combination of tacrolimus and rapamacyn to decrease ischaemia-reperfusion injury in a rat syngenic kidney transplantation model

CLINICAL AND EXPERIMENTAL IMMUNOLOGY; Lugar: Londres; Año: 2012 vol. 167 p. 169 - 177

JURADO, J; PASQUINELLI, V; ALVAREZ, I; PEÑA, D; ROVETTA, A; TATEOSIAN, N; ROMEO, H; MUSELLA, R; PALMERO, D; CHULUYAN, HE; GARCIA, V

IL-17 and IFN-γ expression in lymphocytes from patients with active tuberculosis correlates with the severity of the disease

JOURNAL OF LEUKOCYTE BIOLOGY; Lugar: Bethesda; Año: 2012 vol. 91 p. 991 - 1002

TATEOSIAN, N; COSTA, J; GUERRIERI, D; BARRO, A; MAZZEI, JA; CHULUYAN, HE

Inflammatory mediators in exhaled breath condensate of healthy donors and exacerbated COPD patients

CYTOKINE.; Lugar: Amsterdam; Año: 2012 vol. 58 p. 361 - 367

KOTLIAR C; JUNCOS L; INSERRA F; DE CAVANAGH EM; CHULUYAN E; AQUINO JB; HITA A; NAVARI C; SÁNCHEZ R.

Local and systemic cellular immunity in early renal artery atherosclerosis.

CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY; Año: 2012 vol. 7 p. 224 - 230

AMIANO NO; REITERI RM; COSTA MJ; TATEOSIAN N; CHULUYAN HE

Immunotherapy with SLPI over-expressing mammary tumor cells decreases tumor growth.

CANCER IMMUNOLOGY IMMUNOTHERAPY; Lugar: Berlin; Año: 2011 vol. 60 p. 895 - 900

CICORA F; ROBERTI, J; VASQUEZ, D; GUERRIERI, D; LAUSADA, N; CICORA, P; PALTI, G; CHULUYAN, E; GONZALEZ, P; STRINGA, P; RAIMONDI, C

Preconditioning donor with a combination of tacrolimus and rapamacyn to decrease ischaemia–reperfusion injury in a rat syngenic kidney transplantation model

CLINICAL AND EXPERIMENTAL IMMUNOLOGY; Lugar: Londres; Año: 2011 vol. 167 p. 169 - 177

GUERRIERI, DIEGO; TATEOSIAN, NANCY; MAFFIA, PAULO C; REITERI, ROMINA M; AMIANON, NICOLÁS O; COSTA, MARÍA JULIETA; VILLALONGA, X; SANCHEZ, ML; ESTEIN, SILVIA; GARCIA, VERÓNICA E; SALLENAVE, JEAN-MICHEL; CHULUYAN, H. EDUARDO

Serine leucocyte proteinase inhibitor-treated monocyte inhibits human CD4+ lymphocyte proliferation

IMMUNOLOGY; Lugar: Oxford; Año: 2011 p. 434 - 441

GUAZZONE, VA; GUERRIERI D; JACOBO, P; GLISONI, RJ; CHIAPPETTA, DIEGOAPPETTA; LUSTIG, L; CHULUYAN, HE

Micro-encapsulated Secretory Leukocyte Protease Inhibitor decreases cell-mediated immune response in autoimmune orchitis

LIFE SCIENCES; Lugar: Oxford; Año: 2011 p. 100 - 106

GOMEZ SA, ARGÜELLES CL, GUERRIERI D, TATEOSIAN NL, AMIANO NO, SLIMOVICH R, MAFFIA PC, ABBATE E, MUSELLA RM, GARCIA VE, CHULUYAN HE.

Secretory leukocyte protease inhibitor: a secreted pattern recognition receptor for mycobacteria.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE; Año: 2009 vol. 179 p. 247 - 253

JURADO JO, ALVAREZ IB, PASQUINELLI V, MARTÍNEZ GJ, QUIROGA MF, ABBATE E, MUSELLA RM, CHULUYAN HE, GARCÍA VE

Programmed death (PD)-1:PD-ligand 1/PD-ligand 2 pathway inhibits T cell effector functions during human tuberculosis.

JOURNAL OF IMMUNOLOGY; Año: 2008 vol. 181 p. 116 - 125

GUINJOAN SM, VIGO DE, CASTRO MN, TATEOSIAN N, CHULUYAN E, COSTANZO E, FAHRER R, GRANCELLI H, LEIGUARDA R, CARDINALI DP.

Mood, Th-1/Th-2 cytokine profile, and autonomic activity in older adults with acute/decompensated heart failure: Preliminary observations

The world journal of biological psychiatry; Año: 2008 p. 1 - 6

GARCÍA VE, CHULUYAN HE.

SLAM and CD31: signaling molecules involved in cytokine secretion during the development of innate and adaptive immune responses

Cytokine and growth factor reviews; Año: 2007 vol. 18 p. 85 - 96

MAFFIA PC, ZITTERMANN SE, SCIMONE ML, TATEOSIAN N, AMIANO N, GUERRIERI D, LUTZKY V, ROSSO D, ROMEO HE, GARCIA VE, ISSEKUTZ AC, CHULUYAN HE.

Neutrophil elastase converts human immature dendritic cells into transforming growth factor-beta1-secreting cells and reduces allostimulatory ability.

AMERICAN JOURNAL OF PATHOLOGY; Lugar: Maryland; Año: 2007 vol. 171 p. 928 - 937

QUIROGA MF, JURADO JO, MARTÍNEZ GJ, PASQUINELLI V, MUSELLA RM, ABBATE E, ISSEKUTZ AC, BRACCO MM, MALBRAN A, SIELING PA, CHULUYAN E, GARCÍA VE.

(última autoría compartida) Cross-talk between CD31 and the signaling lymphocytic activation molecule-associated protein during interferon- gamma production against Mycobacterium tuberculosis.

JOURNAL OF INFECTIOUS DISEASES; Año: 2007 vol. 196 p. 1369 - 1378

LUTZKY VP, CARNEVALE RP, ALVAREZ MJ, MAFFIA PC, ZITTERMANN SI, PODHAJCER OL, ISSEKUTZ AC, CHULUYAN HE

Platelet-endothelial cell adhesion molecule-1 (CD31) recycles and induces cell growth inhibition on human tumor cell lines.

JOURNAL OF CELLULAR BIOCHEMISTRY; Lugar: New Jersey; Año: 2006 vol. 98 p. 1334 - 1350

MIRANDA S, LITWIN S, BARRIENTOS G, SZEREDAY L, CHULUYAN E, BARTHO JS, ARCK PC, BLOIS SM

Dendritic cells therapy confers a protective microenvironment in murine pregnancy

SCANDINAVIAN JOURNAL OF IMMUNOLOGY; Año: 2006 vol. 64 p. 493 - 499

SCIMONE ML, LUTZKY V, ZITTERMANN S, MAFFIA P, JANCIC C, CHULUYAN HE.

Recruitment of polymorphonuclear leukocytes by dendritic cells.

IMMUNOLOGY; Año: 2005 vol. 114 p. 375 - 385

ALVAREZ MJ, PRADA F, SALVATIERRA E, BRAVO AI, LUTZKY VP, CARBONE C, PITOSSI FJ, CHULUYAN HE AND PODHAJCER OL.

SPARC Produced by Human Melanoma Cells Modulates polymorphonuclear Leukocytes Recruitment and Anti-tumor Cytotoxic Capacity.

CANCER RESEARCH; Año: 2005 vol. 65 p. 5123 - 5132

BLOIS S, ALBA SOTO CD, OLMOS S, CHULUYAN HE, GENTILE T, ARCK PC, MARGNI RA.

Therapy with Dendritic Cells Influences the Spontaneous Resorption Rate in the CBA/J x DBA/2J Mouse Model.

AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY; Año: 2004 vol. 51 p. 40 - 48

MAFFIA P, ZITTERMANN S, SCIMONE ML, BUZZOLA F, TATEOSIAN N, LUTZKY V, JANCIC C, BARBOSA M, CHULUYAN E.

Polymorphonuclear leukocytes decrease the immunostimulatry capacity of human dendritic cells.

MEDICINA (BUENOS AIRES); Lugar: Buenos Aires; Año: 2004 vol. 64 p. 433 - 435

CHULUYAN HE, ISSEKUTZ AC

VLA-4 integrin can mediate CD11/CD18-independent transendothelial migration of human monocytes

JOURNAL OF CLINICAL INVESTIGATION; Año: 1993 vol. 92 p. 2768 - 2777