INVESTIGADORES
CHULUYAN Hector Eduardo
artículos
Título:
Local and systemic cellular immunity in early renal artery atherosclerosis.
Autor/es:
KOTLIAR C; JUNCOS L; INSERRA F; DE CAVANAGH EM; CHULUYAN E; AQUINO JB; HITA A; NAVARI C; SÁNCHEZ R.
Revista:
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
Editorial:
AMER SOC NEPHROLOGY
Referencias:
Año: 2012 vol. 7 p. 224 - 230
ISSN:
1555-9041
Resumen:
BACKGROUND AND OBJECTIVES:Modern imaging techniques have increased the incidental detection of renal atherosclerotic disease (RAD). Because immune activation may hasten RAD progression, identifying cellular immune markers might provide clues to clinical activity. In this study, cellular immune markers were assessed in early RAD.; MEASUREMENTS: Immune cell markers in peripheral blood of two groups of hypertensive patients with normal carotid and coronary arteries were evaluated: 28 patients had incidental RAD and 22 patients had normal renal arteries; 21 renal arteries obtained at necropsy from individuals with history of hypertension and tissue evidence of RAD were examined and matched with 21 individuals with normal renal arteries. Cell subpopulations were measured by flow cytometry in peripheral blood and direct cell count, respectively, using T and dendritic cells monoclonal antibodies. RESULTS: Peripheral blood of RAD patients showed increased numbers of cells expressing CD3, CD4, CD83, and CD86. CD4 to CD8 ratio was 8.3 ± 1.4 (RAD) to 3.4 ± 0.9 (normal; P