A reduced lactose yogurt containing galactooligosaccharides (GOS) as a tool for lactose intolerant cover calcium daily intake that ensures bone health

SEIJO M.; BONANNO M. ; VÉNICA C.; PITA MARTIN DE PORTELA M. LUZ; BERGAMINI C.; WOLF I.; PEROTTI M. C.; ZENI S.

Congreso; 46th European Calcified Tissue Society Congress; 2019

The galactooligosaccharides (GOS),naturalprebiotics of human milk could be incorporated in dairy products, such asyogurt, by enzymatic action on milk lactose.We previously demonstrated:1st. functional characteristics of such reduced-lactose yogurtcontaining GOS duringthe experimentalnormal growth; 2nd.Ca absorption (CaAbs)similar to that observed byfeeding the recommended rodent diet.  Objetive:To evaluate the beneficial effects of this reduced-lactoseyogurt containingGOS in body composition and bone retentionduringnormal growth. Male weaning Wistar rats (n=10 per group) received during 30days AIN´93-G control diet (CD) or the yogurt containing GOS diet (ED). Foodconsumption was evaluated three times per week; body weight (BW) weekly; Ca andphosphorus (P) Abs during the last 3 days of the experience;femur Ca and Pcontent, total skeleton bone mineral content (BMC) and bone mineral density(BMD) at the end of the study. Body composition andBMD of lumbar spine (LS),total (TT) and proximal (PrT) tibia BMD, and TT BMCwere also evaluated. Result(mean±SD; Food consumption; BW;body fat and lean tissue percentages weresimilar in both groups. BMC (1.29±0.14 vs. 1.32±0.24 g), BMD (0.320±0.010 vs0.320±0.005 g/cm2),TT BMD (0.246±0.022 vs 0.246 ± 0.018 g/cm2) and BMC(0.029±0.004 vs. 0.030±0.014); LS BMD (0.250±0.017 vs. 0.251±0.019 g/cm2) andCa and P content in femur showed no significant differences. CaAbs%(84.9±2.2vs. 80.0±5.4%; p=0.062) and PAbs% (86.6±6.6vs78.0±7.1%;p<0.05); PrT BMD(0.303±0.056 g/cm2 vs. 0.266±0.018; p<0.05) were higher in ED vs. CD. Theresults evidenced similar body composition, higher Ca and P Abs and similarbone mass and retention. Conclusion:These results may suggest thatthereduced lactose milk functional product assayed hereappears to an optimal toolfor maintaining anadequate intake of Ca, which prevents secondary bone disease caused by amilk-restricted diet