Jacaranda oil administration improves serum biomarkers and bioavailability of bioactive conjugated fatty acids, and alters fatty acid profile of mice tissues

VAN NIEUWENHOVE C; MOYANO, A; VAN NIEUWENHOVE, G;; MOLINA, V; LUNA PIZARRO, P

LIPIDS

SPRINGER HEIDELBERG

Lugar: HEIDELBERG; Año: 2021 p. 1 - 12

0024-4201

Jacaric acid, a conjugated linolenic acid (CLNA) present in jacaranda oil (JO),is considered a potent anticarcinogenic agent. Several studies have focusedon its biological effects, but the metabolism once consumed is not clear yet.The aim of this work was to evaluate the effects of two different daily doses ofJO on serum parameters and fatty acid (FA) profile of mice tissues after4 weeks of feeding. No significant changes on body weight gain, food intake, ortissue weight were determined after 0.7 or 2 ml/kg of JO supplementation compared to control animals. Significantly lower blood low-density lipoproteinscholesterol (20 mg/dl) and glucose (147?148 mg/dl) levels were detected inboth oil-treated groups compared to control (31.2 and 165 mg/dl, respectively).Moreover, jacaric acid was partially converted into cis9, trans11 conjugated linoleic acid (CLA) and thus further incorporated into tissues. Liver evidenced thehighest total conjugated fatty acid content (1.1%?2.2%), followed by epididymal(0.7%?1.9%) and mesenteric (1.4%?1.8%) fat. Lower saturated and higherunsaturated fatty acid content was detected in both oil-treated groups compared to control. Our results support the safety of JO and its potential application with a functional or nutraceutical propose, by increasing human CLNAconsumption and further availability of CLA