MORI SEQUEIROS GARCIA, MARÍA MERCEDES; PAZ, CRISTINA; CASTILLO, ANA FERNANDA; BENZO, YANINA; BELLUNO, MATÍAS A.; BALCÁZAR MARTÍNEZ, ARIANA; MALOBERTI, PAULA MARIANA; CORNEJO MACIEL, FABIANA; PODEROSO, CECILIA

New insights into signal transduction pathways in adrenal steroidogenesis: role of mitochondrial fusion, lipid mediators, and MAPK phosphatases

Frontiers in Endocrinology; Año: 2023 vol. 14

PODEROSO, CECILIA; FILIPPI, BEATRICE MARIA; MALOBERTI, PAULA MARIANA; FRANCO, MARIA CLARA

Editorial: Mitochondrial Dynamics in Endocrine Physiology and Disease

Frontiers in Endocrinology; Año: 2022 vol. 13

CASTILLO, ANA F.; ORLANDO, ULISES D.; MALOBERTI, PAULA M.; PRADA, JESICA G.; DATTILO, MELINA A.; SOLANO, ANGELA R.; BIGI, MARÍA M.; RÍOS MEDRANO, MAYRA A.; TORRES, MARÍA T.; INDO, SEBASTIÁN; CAROCA, GRACIELA; CONTRERAS, HECTOR R.; MARELLI, BELKIS E.; SALINAS, FACUNDO J.; SALVETTI, NATALIA R.; ORTEGA, HUGO H.; LORENZANO MENNA, PABLO; SZAJNMAN, SERGIO; GOMEZ, DANIEL E.; RODRÍGUEZ, JUAN B.; PODESTA, ERNESTO J.

New inhibitor targeting Acyl-CoA synthetase 4 reduces breast and prostate tumor growth, therapeutic resistance and steroidogenesis

CELL. MOLEC. LIFE SCIEN.; Año: 2021

MORI SEQUEIROS GARCIA, M. MERCEDES; COHEN SABBAN, JUAN M.; DATTILO, MELINA A.; MELE, PABLO G.; NUDLER, SILVANA I.; MENDEZ, CARLOS F.; MALOBERTI, PAULA M.; PAZ, CRISTINA

Angiotensin II-upregulated MAP kinase phosphatase-3 modulates FOXO1 and p21 in adrenocortical H295R cells

Heliyon; Año: 2020 vol. 6

MELINA DATTILO; YANINA BENZO; HERRERA, LUCIA; JESICA PRADA; LOPEZ PAULA; CARUSO CARLA; LASAGA MERCEDES; GARCIA, CORINA ILEANA; CRISTINA PAZ; PAULA MARIANA MALOBERTI

Regulation and role of Acyl-CoA synthetase 4 in glial cells  

JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY; Lugar: Amsterdam; Año: 2020

MELINA DATTILO; YANINA BENZO; LUCÍA HERRERA; JESICA PRADA; ANA FERNANDA CASTILLO; ORLANDO ULISES; ERNESTO J. PODESTÁ; PAULA MARIANA MALOBERTI

Regulatory mechanisms leading to differential Acyl-CoA synthetase 4 expression in breast cancer cells

Scientific reports; Año: 2019

ORLANDO, ULISES DANIEL; CASTILLO, ANA FERNANDA; MEDRANO, MAYRA AGUSTINA RÍOS; SOLANO, ANGELA ROSARIA; MALOBERTI, PAULA MARIANA; PODESTA, ERNESTO JORGE

Acyl-CoA synthetase-4 is implicated in drug resistance in breast cancer cell lines involving the regulation of energy-dependent transporter expression

BIOCHEMICAL PHARMACOLOGY; Año: 2018 vol. 159 p. 52 - 63

GOROSTIZAGA, ALEJANDRA; MORI SEQUEIROS GARCÍA, MARÍA DE LAS MERCEDES; ACQUIER ANDREA; LOPEZ COSTA JJ; MENDEZ CARLOS; MALOBERTI PAULA; PAZ CRISTINA

ACTH Modulates PTP-PEST Activity and Promotes its Interaction with Paxillin.

Journal of Cell Biochemistry; Año: 2016

CRISTINA PAZ; FABIANA CORNEJO MACIEL; GOROSTIZAGA ALEJANDRA; ANA FERNANDA CASTILLO; MORI SEQUEIROS GARCÍA, MARÍA DE LAS MERCEDES; PAULA MARIANA MALOBERTI; ULISES ORLANDO; MELE PABLO; CECILIA PODEROSO; PODESTA ERNESTO JORGE

Role of Protein Phosphorylation and Tyrosine Phosphatases in the Adrenal Regulation of Steroid Synthesis and Mitochondrial Function.

Frontiers in endocrinology; Año: 2016 vol. 7

CASTILLO ANA FERNANDA; ORLANDO ULISES; LOPEZ PAULA; SOLANO ANGELA; MALOBERTI PAULA; PODESTA ERNESTO JORGE

Gene Expression Profile and Signaling Pathways in MCF-7 Breast Cancer Cells Mediated by Acyl-Coa Synthetase 4 Overexpression

Transcriptomics; Año: 2015 vol. 3

DATTILO MELINA; NEUMAN ISABEL; MUÑOZ MARIANA; MALOBERTI PAULA; CORNEJO MACIEL, FABIANA

OxeR1 regulates angiotensin II and cAMP-stimulated steroid production in human H295R adrenocortical cells.

MOLECULAR AND CELLULAR ENDOCRINOLOGY.; Lugar: Amsterdam; Año: 2015

ORLANDO ULISES; CASTILLO ANA FERNANDA; DATTILO MELINA; SOLANO ANGELA; MALOBERTI PAULA; PODESTA E.J.

Acyl-CoA synthetase-4, a new regulator of mTOR and a potential therapeutic target for enhanced estrogen receptor function in receptor-positive and -negative breast cancer.

ONCOTARGET; Lugar: New York; Año: 2015

ORLANDO ULISES; COOKE MARIANA; CORNEJO MACIEL F.; PAPADOPOULOS VASSILIOS; PODESTA ERNESTO J; MALOBERTI PAULA

Characterization of the mouse promoter region of the acyl-CoA synthetase 4 gene: Role of Sp1 and CREB.

MOLECULAR AND CELLULAR ENDOCRINOLOGY.; Lugar: Amsterdam; Año: 2013 vol. 369 p. 15 - 26

GOROSTIZAGA ALEJANDRA; MORI SEQUEIROS GARCÍA, MARÍA DE LAS MERCEDES; ACQUIER ANDREA; GOMEZ NATALIA; MALOBERTI PAULA; MENDEZ CARLOS F; PAZ CRISTINA

Modulation of albumin-induced endoplasmic reticulum stress in renal proximal tubule cells by upregulation of mapk phosphatase-1.

CHEMICO-BIOLOGICAL INTERACTIONS; Lugar: Amsterdam; Año: 2013 vol. 206 p. 47 - 54

COOKE MARIANA; DI CONSOLI HERNAN; MALOBERTI PAULA; CORNEJO MACIEL, FABIANA

Expression and function of OXE receptor, an eicosanoid receptor, in steroidogenic cells

MOLECULAR AND CELLULAR ENDOCRINOLOGY.; Lugar: Amsterdam; Año: 2013 vol. 371 p. 71 - 78

ORLANDO ULISES; GARONA J; RIPOLL G; MALOBERTI PAULA; SOLANO ANGELA; AVAGNINA A.; GOMEZ D.; ALONSO D; PODESTA ERNESTO JORGE

The functional interaction between Acyl-CoA synthetase 4, 5-lipooxygenase and cyclooxygenase-2 controls tumor growth: a novel therapeutic target.

PLOS ONE; Lugar: San Francisco; Año: 2012 p. 1 - 14

BRION, LAURA; MALOBERTI PAULA; GOMEZ NATALIA; PODEROSO CECILIA; GOROSTIZAGA ALEJANDRA; MORI SEQUEIROS GARCÍA, MARÍA DE LAS MERCEDES; ACQUIER ANDREA; COOKE MARIANA; MENDEZ, CARLOS; PODESTÁ ERNESTO J.; PAZ CRISTINA

MAPK Phosphatase-1 (MKP-1) Expression Is Up-Regulated by hCG/cAMP and Modulates Steroidogenesis in MA-10 Leydig Cells

ENDOCRINOLOGY; Año: 2011 vol. 152 p. 2665 - 2677

MARIANA COOKE; ULISES ORLANDO; PAULA MALOBERTI; ERNESTO J. PODESTÁ; FABIANA CORNEJO MACIEL

Tyrosine phosphatase SHP2 regulates the expression of acyl-CoA synthetase ACSL4

JLR PAPERS IN PRESS; Año: 2011 vol. 52 p. 1936 - 1948

MALOBERTI PAULA; DUARTE ALEJANDRA; ORLANDO ULISES; PASQUALINI MARÍA EUGENIA; SOLANO ANGELA; LOPEZ OTIN CARLOS; PODESTA ERNESTO JORGE

Functional interaction between acyl-CoA synthetase 4, lipooxygenases and cyclooxygenase-2 in the aggressive phenotype of breast cancer cells.

PLOS ONE; Lugar: San Francisco; Año: 2010 vol. 5 p. 1 - 12

COOKE MARIANA; MELE PABLO; MALOBERTI PAULA; DUARTE ALEJANDRA; PODEROSO CECILIA; ORLANDO ULISES; CORNEJO MACIEL, FABIANA; PAZ CRISTINA

Tyrosine phosphatases as key regulators of StAR induction and cholesterol transport: SHP2 as a potential tyrosine phosphatase involved in steroid synthesis.

MOLECULAR AND CELLULAR ENDOCRINOLOGY.; Lugar: Amsterdam; Año: 2010 vol. 336 p. 63 - 69

PODEROSO CECILIA; MALOBERTI PAULA; DUARTE ALEJANDRA; NEUMAN ISABEL; PAZ CRISTINA; CORNEJO MACIEL, FABIANA; PODESTA, ERNESTO J

Hormonal activation of a kinase cascade localized at the mitochondria is required for StAR protein activity

MOLECULAR AND CELLULAR ENDOCRINOLOGY.; Lugar: Ireland; Año: 2009 vol. 300 p. 37 - 42

PAZ CRISTINA; PODEROSO CECILIA; MALOBERTI PAULA; CORNEJO MACIEL, FABIANA; MENDEZ, CARLOS; PODEROSO JUAN; PODESTA ERNESTO J

Detection of a mitochondrial kinase complex that mediates PKA-MEK-ERK-dependent phosphorylation of mitochondrial proteins involved in the regulation of steroid biosynthesis.

METHODS IN ENZYMOLOGY.; Lugar: Burlington, MA, Estados Unidos; Año: 2009 vol. 457 p. 169 - 192

PODEROSO CECILIA; CONVERSO DANIELA; MALOBERTI PAULA; DUARTE ALEJANDRA; NEUMAN ISABEL; GALLI SOLEDAD; MACIEL FABIANA CORNEJO; PAZ CRISTINA; CARRERAS MARÍA CECILIA; PODEROSO JUAN; PODESTA ERNESTO JORGE

A mitochondrial kinase complex is essential to mediate an ERK1/2-dependent phosphorylation of a key regulatory protein in steroid biosynthesis.

PLOS ONE; Año: 2008 vol. 3 p. 1 - 11

CASTILLO ANA FERNANDA; CASTILLA ROCÍO; DUARTE ALEJANDRA; MELE PABLO; ORLANDO ULISES; KARLES CRISTINA; NEUMAN ISABEL; DI CONSOLI HERNAN; PODEROSO CECILIA; SOLANO ANGELA; FINKIELSTEIN CARLA; MALOBERTI PAULA; CORNEJO MACIEL FABIANA; PAZ CRISTINA; PODESTA ERNESTO JORGE

Review: Intramitochondrial arachidonic acid as regulator of two different cellular functions: steroid biosynthesis and tumor cell proliferation.

Current trends in endocrinology; Año: 2008 vol. 3 p. 57 - 75

PODEROSO CECILIA; MALOBERTI PAULA; DUARTE ALEJANDRA; CASTILLA ROCÍO; NEUMAN ISABEL; PAZ CRISTINA; CORNEJO MACIEL, FABIANA; PODESTA ERNESTO J

Review: The Steroidogenic Acute Regulatory (StAR) protein as target for multiple kinases. Roles of protein phosphorylation on StAR function.

Current Topics in Steroid Research; Año: 2008 vol. 5 p. 35 - 49

DUARTE ALEJANDRA; CASTILLO ANA FERNANDA; CASTILLA ROCÍO; MALOBERTI PAULA; PAZ CRISTINA; PODESTA ERNESTO JORGE; CORNEJO MACIEL FABIANA

An arachidonic acid generation/export system involved in the regulation of cholesterol transport in mitochondria of steroidogenic cells.

FEBS LETTERS; Lugar: Amsterdam, Holanda; Año: 2007 vol. 581 p. 4023 - 4028

GOROSTIZAGA ALEJANDRA; CORNEJO MACIEL FABIANA; BRION LAURA; MALOBERTI PAULA; PODESTA ERNESTO JORGE; PAZ CRISTINA

Tyrosine phosphatases in steroidogenic cells: regulation and function.

MOLECULAR AND CELLULAR ENDOCRINOLOGY.; Año: 2007 vol. 265 p. 131 - 137

MALOBERTI PAULA; CORNEJO MACIEL FABIANA; CASTILLO ANA FERNANADA; CASTILLA ROCÍO; DUARTE ALEJANDRA; TOLEDO MARÍA FERNANDA; MEULI FLAVIA; MELE PABLO; PAZ CRISTINA; PODESTA ERNESTO J

Enzymes involved in arachidonic acid release in adrenal and Leydig cells. Review.

MOLECULAR AND CELLULAR ENDOCRINOLOGY.; Lugar: Amsterdam, Holanda; Año: 2007 vol. 265 p. 113 - 120

CASTILLO ANA FERNANDA; MACIEL FABIANA CORNEJO; CASTILLA ROCÍO; DUARTE ALEJANDRA; MALOBERTI PAULA; PAZ CRISTINA; PODESTA ERNESTO JORGE

cAMP increases mitochondrial cholesterol transport through the induction of arachidonic acid release inside this organelle in Leydig cells.

FEBS JOURNAL; Lugar: Inglaterra; Año: 2006 vol. 273 p. 5011 - 5021

FLORENCIA CANO; CECILIA PODEROSO; FABIANA CORNEJO MACIEL; ROCÍO CASTILLA; PAULA MALOBERTI; FERNANDA CASTILLO; ISABEL NEUMAN; CRISTINA PAZ; ERNESTO J. PODESTÁ

Protein tyrosine phosphatases regulate arachidonic acid release, StAR induction and steroidogenesis acting on a hormone-dependent arachidonic acid-preferring acyl-CoA synthetase

JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY; Lugar: Inglaterra; Año: 2006 vol. 99 p. 197 - 202

CORNEJO MACIEL, FABIANA; MALOBERTI PAULA; NEUMAN ISABEL; CANO FLORENCIA; CASTILLA ROCÍO; CASTILLO ANA FERNANDA; PAZ CRISTINA; PODESTÁ ERNESTO JORGE

An arachidonic acid-preferring acyl-CoA synthetase is a hormone-dependent and obligatory protein in the signal transduction pathway of steroidogenic hormones.

JOURNAL OF MOLECULAR ENDOCRINOLOGY; Año: 2005 vol. 34 p. 655 - 666

GOROSTIZAGA ALEJANDRA; BRION LAURA; MALOBERTI PAULA; MACIEL FABIANA CORNEJO; PODESTÁ ERNESTO JORGE; PAZ CRISTINA

Heat shock triggers MAPK activation and MKP-1 induction in Leydig testicular cells.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS; Año: 2005 vol. 327 p. 23 - 28

MALOBERTI PAULA; CASTILLA ROCÍO; CASTILLO ANA FERNANDA; MACIEL FABIANA CORNEJO; MENDEZ CARLOS; PAZ CRISTINA; PODESTA ERNESTO JORGE

Silencing the expression of mitochondrial acyl-CoA thioesterase I and acyl-CoA synthetase 4 inhibits hormone-induced steroidogenesis.

FEBS JOURNAL; Año: 2005 vol. 272 p. 1804 - 1814

CASTILLO, FERNANDA; CANO, FLORENCIA; MALOBERTI, PAULA; CASTILLA, ROCÍO; NEUMAN, ISABEL; PODEROSO, CECILIA; PAZ, CRISTINA; PODESTÁ, ERNESTO J.; MACIEL, FABIANA CORNEJO

Tyrosine phosphates act on steroidogenesis through the activation of arachidonic acid release

ENDOCRINE RESEARCH; Año: 2004 vol. 30 p. 623 - 627

BEY PAULA; GOROSTIZAGA, ALEJANDRA; MALOBERTI PAULA; CASTILLA ROCÍO; PODEROSO CECILIA; CORNEJO MACIEL, FABIANA; PODESTÁ ERNESTO J.; PAZ CRISTINA

Adrenocorticotropin induces mitogen-activated protein kinase phosphatase 1 in Y1 mouse adrenocortical tumor cells.

ENDOCRINOLOGY; Año: 2003 vol. 144 p. 1399 - 1406

MALOBERTI PAULA; CASTILLA ROCÍO; MELE PABLO; CANO FLORENCIA; COLONNA CECILIA; MENDEZ CARLOS; PAZ CRISTINA; PODESTÁ ERNESTO J.

Concerted regulation of free arachidonic acid and hormone-induced steroid synthesis by acyl-CoA thioesterases and acyl-CoA synthetases in adrenal cells

EUROPEAN JOURNAL OF BIOCHEMISTRY; Lugar: Oxford, Ingalterra; Año: 2002 vol. 269 p. 5599 - 5607

PAZ CRISTINA; CORNEJO MACIEL, FABIANA; MALOBERTI PAULA; WALSH LP; STOCCO DM; PODESTÁ ERNESTO J.

Protein tyrosine phosphatases are involved in LH/chorionic gonadotropin and 8Br-cAMP regulation of steroidogenesis and StAR protein levels in MA-10 Leydig cells.

JOURNAL OF ENDOCRINOLOGY; Lugar: Bristol UK; Año: 2002 vol. 175 p. 793 - 801

NEUMAN ISABEL; MALOBERTI PAULA; LISDERO CONSTANZA; COLONNA CECILIA; PERALTA JORGE; PODEROSO JUAN JOSE; PODESTÁ ERNESTO J.

beta-Adrenergic stimulation controls the expression of a thioesterase specific for very-long-chain fatty acids in perfused hearts.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS; Lugar: San Diego; Año: 2002 vol. 299 p. 135 - 141

CYMERYNG CORA; LOTITO SEBASTIAN; COLONNA CECILIA; FINKIELSTEIN CARLA; POMERANIEC YAEL; GRION NATALIA; GADDA LUCIANA; MALOBERTI PAULA; PODESTÁ ERNESTO J.

Expression of nitric oxide synthases in rat adrenal zona fasciculata cells.

ENDOCRINOLOGY; Lugar: Chevy Chase; Año: 2002 vol. 143 p. 1235 - 1242

CASTILLA LOZANO, ROCÍO; MALOBERTI, PAULA; MENDEZ, CARLOS F.; PAZ, CRISTINA; PODESTÁ, ERNESTO J.

ACTH regulation of mitochondrial acyl-CoA thioesterase activity in Y1 adrenocortical tumour cells

ENDOCRINE RESEARCH; Año: 2002 vol. 28 p. 331 - 337

MALOBERTI PAULA; MELE PABLO; CORNEJO MACIEL FABIANA; CANO FLORENCIA; BEY PAULA; PAZ CRISTINA; PODESTA ERNESTO J

Regulation of arachidonic acid release in steroidogenesis: Role of a new acyl-CoA thioesterase (ARTISt).

ENDOCRINE RESEARCH; Lugar: Londres, Inglaterra; Año: 2000 vol. 26 p. 653 - 662

NEUMAN ISABEL; LISDERO CONSTANZA; FINKIELSTEIN CARLA; MALOBERTI PAULA; MENDEZ, CARLOS; PODEROSO JUAN JOSE; PODESTÁ ERNESTO J.

Activation of a thioesterase specific for very-long-chain fatty acids by adrenergic agonists in perfused hearts.

BIOCHIMICA AND BIOPHYSICA ACTA; Lugar: Amsterdam; Año: 1999 vol. 1451 p. 101 - 108

FINKIELSTEIN CARLA; MALOBERTI PAULA; MENDEZ CARLOS; PAZ CRISTINA; CORNEJO MACIEL, FABIANA; CYMERYNG CORA; NEUMAN ISABEL; DADA LAURA; MELE PABLO; SOLANO ANGELA; PODESTÁ ERNESTO J.

An adrenocorticotropin-regulated phosphoprotein intermediary in steroid synthesis is similar to an acyl-CoA thioesterase enzyme.

EUROPEAN JOURNAL OF BIOCHEMISTRY; Lugar: Oxford, Ingalterra; Año: 1998 vol. 256 p. 60 - 66

FINKIELSTEIN, CARLA V.; MALOBERTI, PAULA; MENDEZ, CARLOS F.; PODESTÁ, ERNESTO J.

A novel Arachidonic acid-Related Thioesterase Involved in acute Steroidogenesis

ENDOCRINE RESEARCH; Año: 1998 vol. 24 p. 363 - 371

DADA, LAURA; MACIEL, FABIANA CORNEJO; NEUMAN, ISABEL; MELE, PABLO G.; MALOBERTI, PAULA; PAZ, CRISTINA; CYMERYNG, CORA; FINKIELSTEIN, CARLA; MENDEZ, CARLOS F.; PODESTÁ, ERNESTO J.

Cytosolic and mitochondrial proteins as possible targets of cycloheximide effect on adrenal steroidogenesis

ENDOCRINE RESEARCH; Año: 1996 vol. 22 p. 533 - 539

FINKIELSTEIN, CARLA; CYMERYNG, CORA; PAZ, CRISTINA; NEUMAN, ISABEL; DADA, LAURA; MACIEL, FABIANA CORNEJO; MELE, PABLO G.; MENDEZ, CARLOS F.; MALOBERTI, PAULA; SOLANO, ANGELA R.; SCHIMMER, BERNARD P.; PODESTÁ, ERNESTO J.

Characterization of the cDNA corresponding to a phosphoprotein (p43) intermediary in the action of ACTH

ENDOCRINE RESEARCH; Año: 1996 vol. 22 p. 521 - 532