Editorial: Mitochondrial Dynamics in Endocrine Physiology and Disease

PODEROSO, CECILIA; FILIPPI, BEATRICE MARIA; MALOBERTI, PAULA MARIANA; FRANCO, MARIA CLARA

Frontiers in Endocrinology

Frontiers Media S.A.

Año: 2022 vol. 13

Mitochondria are important energy sensors; they modulate their activity to meet the energy demands of the cell. Changes in the cellular nutritional status are sensed by the mitochondria, eliciting a response that ranges from changes in mitochondrial morphology to alterations in the efficiency of oxidative phosphorylation. For example, when the cellular energy demand increases, mitochondria tend to fuse together (fusion) to increase the efficiency of oxidative phosphorylation and ATP production. Conversely, an excess of energy can lead to mitochondria separation (fission). These dynamic changes are tightly modulated and appear to be dysregulated in many metabolic and endocrine diseases. In this Research Topic, we aim to bring together complementary reviews, perspectives, and original research articles reflecting on how mitochondria dynamics regulate the normal physiological and endocrine functions, and how the alteration of these functions associates with disease processes.