GHANEM, CAROLINA I; MANAUTOU, JOSE E

Role and regulation of hepatobiliary ATP-Binding Cassete (ABC) transporters during chemical-induced liver injury.

Drug Metabolism and Disposition; Año: 2022

ROCHA-PEREIRA, CAROLINA; GHANEM, CAROLINA I.; SILVA, RENATA; CASANOVA, ALFREDO G.; DUARTE-ARAÚJO, MARGARIDA; GONÇALVES-MONTEIRO, SALOMÉ; SOUSA, EMÍLIA; BASTOS, MARIA DE LOURDES; REMIÃO, FERNANDO

P-glycoprotein activation by 1-(propan-2-ylamino)-4-propoxy-9H-thioxanthen-9-one (TX5) in rat distal ileum: ex vivo and in vivo studies

TOXICOLOGY AND APPLIED PHARMACOLOGY; Año: 2020 vol. 386

SCIALIS, RENATO J.; GHANEM, CAROLINA I.; MANAUTOU, JOSÉ E.

The modulation of transcriptional expression and inhibition of multidrug resistance associated protein 4 (MRP4) by analgesics and their primary metabolites

Current Research in Toxicology; Año: 2020 vol. 1 p. 34 - 41

VIGO, MARÍA BELÉN; PÉREZ, MARÍA JULIA; DE FINO, FERNANDA; GÓMEZ, GIMENA; MARTÍNEZ, SONIA A.; BISAGNO, VERONICA; DI CARLO, MARÍA BEATRIZ; SCAZZIOTA, ALEJANDRA; MANAUTOU, JOSÉ E.; GHANEM, CAROLINA I.

Acute acetaminophen intoxication induces direct neurotoxicity in rats manifested as astrogliosis and decreased dopaminergic markers in brain areas associated with locomotor regulation

BIOCHEMICAL PHARMACOLOGY; Año: 2019 vol. 170

MARTINS, EVA; SILVA, VERA; LEMOS, AGOSTINHO; PALMEIRA, ANDREIA; PUTHONGKING, PLOENTHIP; SOUSA, EMÍLIA; ROCHA-PEREIRA, CAROLINA; GHANEM, CAROLINA I.; CARMO, HELENA; REMIÃO, FERNANDO; SILVA, RENATA

Newly synthesized oxygenated xanthones as potential P-glycoprotein activators: In vitro, ex vivo, and in silico studies

MOLECULES; Año: 2019 vol. 24

GHANEM, CAROLINA I.; MANAUTOU, JOSE E.

Modulation of hepatic MRP3/ABCC3 by xenobiotics and pathophysiological conditions: Role in drug pharmacokinetics

CURRENT MEDICINAL CHEMISTRY.; Año: 2019 vol. 26 p. 1185 - 1223

LONDERO, ANA SOFÍA; ARANA, MAITE ROCÍO; PERDOMO, VIRGINIA GABRIELA; TOCCHETTI, GUILLERMO NICOLÁS; ZECCHINATI, FELIPE; GHANEM, CAROLINA INÉS; RUIZ, MARÍA LAURA; RIGALLI, JUAN PABLO; MOTTINO, ALDO DOMINGO; GARCÍA, FABIANA; VILLANUEVA, SILVINA STELLA MARIS

Intestinal multidrug resistance-associated protein 2 is down-regulated in fructose-fed rats

JOURNAL OF NUTRITIONAL BIOCHEMISTRY; Año: 2017 vol. 40 p. 178 - 186

GHANEM, CAROLINA I.; PÉREZ, MARÍA J.; MANAUTOU, JOSÉ E.; MOTTINO, ALDO D.

Acetaminophen from liver to brain: New insights into drug pharmacological action and toxicity

PHARMACOLOGICAL RESEARCH; Año: 2016 vol. 109 p. 119 - 131

RIGALLI, JUAN PABLO; PERDOMO, VIRGINIA GABRIELA; CIRIACI, NADIA; FRANCÉS, DANIEL ELEAZAR ANTONIO; RONCO, MARÍA TERESA; BATAILLE, AMY MICHELE; GHANEM, CAROLINA INÉS; RUIZ, MARÍA LAURA; MANAUTOU, JOSÉ ENRIQUE; CATANIA, VIVIANA ALICIA

The antitripanocide benznidazole promotes adaptive response to oxidative injury: Involvement of the nuclear factor-erythroid 2-related factor-2 (Nrf2) and multidrug resistance associated protein 2 (MRP2)

TOXICOLOGY AND APPLIED PHARMACOLOGY; Año: 2016 vol. 304 p. 90 - 98

GHANEM CI; RUDRAIAH S; BATAILLE AM; VIGO MB; GOEDKEN MJ; MANAUTOU JE

ROLE OF NUCLEAR FACTOR-ERYTHROID 2-RELATED FACTOR 2 (Nrf2) IN THE TRANSCRIPTIONAL REGULATION OF BRAIN ABC TRANSPORTERS DURING ACUTE ACETAMINOPHEN (APAP) INTOXICATION IN MICE.

BIOCHEMICAL PHARMACOLOGY; Lugar: Amsterdam; Año: 2015 vol. 94 p. 203 - 211

RIGALLI JP; CIRIACI N; ARIAS A; CEVALLOS, MP; VILLANUEBA SS; LUQUITA MG.; MOTTINO AD; GHANEM CI; CATANIA VA; RUIZ ML

REGULATION OF MULTIDRUG RESISTANCE PROTEINS BY GENISTEIN IN A HEPATOCARCINOMA CELL LINE. IMPACT ON SORAFENIB CYTOTOXICITY.

PLOS ONE; Lugar: San Francisco; Año: 2015 vol. 10

NOVAK A; GODOY YC; MARTINEZ SA; GHANEM CI; CELLUCH SM

FRUCTOSE-INDUCED METABOLIC SYNDROME DECREASES PROTEIN EXPRESSION AND ACTIVITY OF INTESTINAL P-GLYCOPROTEIN.

NUTRITION; Lugar: Amsterdam; Año: 2015 vol. 31 p. 871 - 876

BLAZQUEZ AG; BRIZ, O; GOMZALEZ-SANCHEZ, E; PERÉZ MJ; GHANEM CI; MARIN, JJ

The effect of acetaminophen on the expression of BCRP in trophoblast cells impairs the placental barrier to bile acids during maternal cholestasis.

TOXICOLOGY AND APPLIED PHARMACOLOGY; Lugar: Amsterdam; Año: 2014 vol. 277 p. 77 - 84

RAINERI M; GONZALÉZ B; RIVERO-ECHETO C; MUÑIZ JA; GUTIERREZ ML; GHANEM CI; CADET JC; GARCÍA-RILL E; URBANO FJ; BISAGNO V

DIFFERENTIAL EFFECTS OF ENVIRONMENT-INDUCED CHANGES IN BODY TEMPERATURE ON MODAFINIL'S ACTIONS AGAINST METHAMPHETAMINE-INDUCED STRIATAL TOXICITY IN MICE.

NEUROTOXICITY RESEARCH; Lugar: Berlin; Año: 2014 vol. 27 p. 71 - 83

NOVAK A.; DELLI CARPINI G.; RUIZ ML.; LUQUITA MG.; RUBIO MC.; MOTTINO AD.; GHANEM CI.

ACETAMINOPHEN INHIBITS INTESTINAL P-GLYCOPROTEIN TRANSPORT ACTIVITY

JOURNAL OF PHARMACEUTICAL SCIENCES; Lugar: New York; Año: 2013 vol. 102 p. 3830 - 3837

GHANEM, C. I.; ARIAS A.; NOVAK, A.; DELLI CARPINI G.; VILLANUEVA,S.S. .; BLAZQUEZ A. G.; MARIN, J.J.G.; MOTTINO,A.D.; RUBIO M. C.

Acetaminophen-induced stimulation of MDR1 expression and activity in rat intestine and in LS 174T human intestinal cell line.

BIOCHEMICAL PHARMACOLOGY; Año: 2011 vol. 81 p. 244 - 250

GHANEM,C.I.; RUIZ,M.L.; VILLANUEVA,S.S.; LUQUITA,M.G.; LLESUY,S.; CATANIA,V.A.; BENGOCHEA L. A.; MOTTINO,A.D.

Effect of repeated administration with subtoxic doses of acetaminophen to rats on enterohepatic recirculation of a subsequent toxic dose.

BIOCHEMICAL PHARMACOLOGY; Año: 2009 vol. 77 p. 1621 - 1628

VILLANUEBA SS; RUIZ ML; GHANEM, C. I.; LUQUITA,M.G.; CATANIA,V.A; MOTTINO,A.D.

Hepatic synthesis and urinary elimination of acetaminophen glucuronide are exacerbated in bile duct-ligated rats.

Drug Metabolism and Disposition; Año: 2008 vol. 36 p. 475 - 480

GHANEM,C.I.; GOMEZ,P.C.; ARANA,M.C.; PERASSOLO,M; DELLI CARPINI G.; LUQUITA,M.G.; VEGGI,L.M.; CATANIA,V.A.; BENGOCHEA,L.A.; MOTTINO,A.D.

Induction of rat intestinal p-glycoprotein by spironolactone and its effect on absorption of orally administered digoxin

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS; Año: 2006 vol. 318 p. 1146 - 1152

GHANEM,C.I.; RUIZ,M.L.; VILLANUEVA,S.S.; LUQUITA,M.G.; CATANIA,V.A.; JONES,B.; BENGOCHEA,L.A.; VORE,M.; MOTTINO,A.D.

Shift from biliary to urinary elimination of acetaminophen-glucuronide in acetaminophen-pretreated rats

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS; Año: 2005 vol. 315 p. 987 - 995

GHANEM,C.I.; GOMEZ,P.C.; ARANA,M.C.; PERASSOLO,M.; RUIZ,M.L.; VILLANUEVA,S.S. .; OCHOA,E.J.; CATANIA,V.A.; BENGOCHEA,L.A.; MOTTINO,A.D

Effect of acetaminophen on expression and activity of rat liver multidrug resistance-associated protein 2 and P-glycoprotein

BIOCHEMICAL PHARMACOLOGY; Año: 2004 vol. 68 p. 791 - 798

GHANEM, C. I.; C. GOMEZ,P.C.; ARANA,C.; BENGOCHEA,L

Paracetamol overdose and experimental cholestasis induced gene expression regulation that codified P-Glycoprotein type 1 in rats

ACTA GASTROENTEROLOGICA LATINOAMERICANA.; Año: 2002 vol. 32 p. 79 - 82

GHANEM, C.; GHISOLFI, C.; SCORTICATI, C.; LEMBERG, A.; PERAZZO,J.C.; BENGOCHEA,L.

Does TNF-alpha contribute to liver disease physiopathology?

ACTA GASTROENTEROLOGICA LATINOAMERICANA.; Año: 2000 vol. 30 p. 151 - 154

GHANEM,C.; GHISOLFI,C.; SCORTICATI,C.; LEMBERG,A.; PERAZZO,J.C.; BENGOCHEA,L.

Benzodiazepines metabolism in various models of experimental liver diseases

ACTA GASTROENTEROLOGICA LATINOAMERICANA.; Año: 1999 vol. 29 p. 3 - 7

BENGOCHEA,L.; GHANEM,C.; PERAZZO,J.C.; GHISOLFI,C.; MARABOTTO,L.; ACEVEDO,C.; MINO,J.; LEMBERG,A.; RUBIO,M

Drug glucuronidation and hepatic lipid microsomal membrane profile in cholestatic rats followed paracetamol intoxication

PHARMACOLOGICAL RESEARCH; Año: 1999 vol. 40 p. 369 - 376

GHANEM,C.; GHISOLFI,C.; MARABOTTO,L.; OUVINA,G. .; RUBIO,M.; PERAZZO,J.; LEMBERG,A.; BENGOCHEA,L

Lipid changes in hepatic microsomes and its relationship to P-nitrophenol glucuronidation in an experimental model of portal hypertension

ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY; Año: 1997 vol. 105 p. 607 - 610