Benzodiazepines metabolism in various models of experimental liver diseases

GHANEM,C.; GHISOLFI,C.; SCORTICATI,C.; LEMBERG,A.; PERAZZO,J.C.; BENGOCHEA,L.

ACTA GASTROENTEROLOGICA LATINOAMERICANA.

Año: 1999 vol. 29 p. 3 - 7

0300-9033

The aim of the present paper is to establish possible disturbances in benzodiazepines glucuronidation in two experimental models of liver injury: paracetamol acute intoxication and cholestasis followed by paracetamol acute intoxication. We concluded that, despite the alterations observed in liver microsomal lipid profile, glucuronidation remained similar to controls in paracetamol intoxicated rats. On the contrary, cholestatic animals followed by paracetamol intoxication showed an increment in the glucuronidation of the utilized substrated