Does TNF-alpha contribute to liver disease physiopathology?

GHANEM, C.; GHISOLFI, C.; SCORTICATI, C.; LEMBERG, A.; PERAZZO,J.C.; BENGOCHEA,L.

ACTA GASTROENTEROLOGICA LATINOAMERICANA.

Año: 2000 vol. 30 p. 151 - 154

0300-9033

The aim of the present paper is to establish the possible role of serum TNF in the pathophysiology of three experimental models of liver injury: paracetamol intoxication, cholestasis followed by paracetamol intoxication and cholestasis. We concluded that under our experimental conditions the serum TNF-alpha levels were not responsible for the inflammatory phenomena described in our previous paper as apoptosis