CONICET | Buscador de Institutos y Recursos Humanos

Age-related macular degeneration (AMD) is a progressive retinal disease and is the leadingcause of visual impairment in elderly people in western countries, for which there is still nocure. Genetics, environmental insults, and age-related issues are risk factors for the developmentof the disease and all these are linked to oxidative stress induction. Also, degeneration of retinalpigment epithelial cells (RPE) is a crucial causative factor responsible for the onset and progressionof AMD. With the population aging, AMD will gradually become in a globally prevalent disease.The decline in the quality of life among affected patients highlights a critical need for developingpreventive strategies. In this sense, phytochemicals with both antioxidant and anti-inflammatoryproperties may have a potential role in the prevention and treatment of this ocular disease.Particularly, there is an increased interest in the therapeutic effects of resveratrol (RSV). RSV isa naturally occurring polyphenolic compounds from the stilbenes family, mainly found in blackgrape and peanuts. RSV has beneficial effects on human health, including its neuroprotection, antiinflammatoryaction, potent antioxidant activity and antiaging effects. Our research line is focusedin investigating the protective effectiveness of RSV in an in vitro model of AMD. In addition,we designed and developed chitosan-based nanocarriers for RSV encapsulation to overcomephysicochemical and pharmacokinetic limitations such as poor oral bioavailability, low watersolubility and photosensibility. In summary, chitosan nanoparticles are a promising platform forocular bioactives (eg. RSV) delivery for therapeutic intervention against oxidative stress-associateddiseases, such as AMD.

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