Insulin-chitosan interactions for the protein nanocarriers design

CECILIA PRUDKIN SILVA; KARINA D MARTÍNEZ; OSCAR E PÉREZ

Buenos Aires

Congreso; II Workshop POLÍMEROS BIODEGRADABLES Y BIOCOMPUESTOS and III Workshop on Biobased Polyurethane Composites and Natural Fillers, BIOPURFIL; 2015

European project BIOPURFIL

This contribution is part of a more extensive project which aim is the development of nanocarriers for insulin. These nanocarriers will be generated under the concept of molecular "self-assembly"[1]. Such matrices will be employed in the encapsulation and controlled delivery for insulin [2]. The encapsulating material is chitosan (CH) [3], which is a biodegradable, biocompatible and non-toxic polysaccharide derived from chitin. Punctually, the specific objective here was to quantify the interactions degree for these chemical species at pH values where the electrostatic interactions would be favored.