VETTORAZZI, MARCELA; DÍAZ, IVÁN; ANGELINA, EMILIO; SALIDO, SOFÍA; GUTIERREZ, LUCAS; ALVAREZ, SERGIO E.; COBO, JUSTO; ENRIZ, RICARDO D.

Second generation of pyrimidin-quinolone hybrids obtained from virtual screening acting as sphingosine kinase 1 inhibitors and potential anticancer agents

BIOORGANIC CHEMISTRY; Año: 2024 vol. 144

BLANCO H; PEREZ C; BANCHIO C; ALVAREZ SE*; CIUFFO GM

Neurite outgrowth induced by stimulation of Angiotensin II AT2 receptors in SH-SY5Y neuroblastoma cells involves c-Src activation

Heliyon; Año: 2023 vol. 9

PEREZ C; FALCON C; DELGADO MONS J; CUELLO ORLANDI SF; SANGIACOMO M; FERNANDEZ JM; GUERRERO ME; BENITO PG; COLOMBO MI; ZOPPINO F; ALVAREZ SE

Melanoma cells with acquired resistance to vemurafenib have decreased autophagic flux and display enhanced ability to transfer resistance

BIOCHIMICA ET BIOPHYSICA ACTA. MOLECULAR BASIS OF DISEASE; Lugar: Amsterdam; Año: 2023

CAMPOS, LUDMILA E.; GARIBOTTO, FRANCISCO; ANGELINA, EMILIO; KOS, JIRI; GONEC, TOMAS; MARVANOVA, PAVLINA; VETTORAZZI, MARCELA; ORAVEC, MICHAL; JENDRZEJEWSKA, IZABELA; JAMPILEK, JOSEF; ALVAREZ, SERGIO E.; ENRIZ, RICARDO D.

Hydroxynaphthalenecarboxamides and substituted piperazinylpropandiols, two new series of BRAF inhibitors. A theoretical and experimental study

BIOORGANIC CHEMISTRY; Año: 2020

RODRIGUEZ, YAMILA I.; CAMPOS, LUDMILA E.; CASTRO, MELINA G.; BANNOUD, NADIA; BLIDNER, ADA G.; FILIPPA, VERÓNICA P.; CROCI, DIEGO O.; RABINOVICH, GABRIEL A.; ALVAREZ, SERGIO E.

Tumor Necrosis Factor Receptor-1 (p55) Deficiency Attenuates Tumor Growth and Intratumoral Angiogenesis and Stimulates CD8+ T Cell Function in Melanoma

Cells; Lugar: Basilea; Año: 2020 vol. 9

CAMPOS, LUDMILA E.; GARIBOTTO, FRANCISCO M.; ANGELINA, EMILIO; KOS, JIRI; TOMASIC, TIHOMIR; ZIDAR, NACE; KIKELJ, DANIJEL; GONEC, TOMAS; MARVANOVA, PAVLINA; MOKRY, PETR; JAMPILEK, JOSEF; ALVAREZ, SERGIO E.; ENRIZ, RICARDO D.

Searching new structural scaffolds for BRAF inhibitors. An integrative study using theoretical and experimental techniques

BIOORGANIC CHEMISTRY; Año: 2019 vol. 91

VETTORAZZI M; VILA L; LIMA S; ACOSTA L; YEPES F; PALMA A; COBO J; TENGLER J; MALIK I; ALVAREZ SE; MARQUES E; CABEDO N; JESUS SANZ M; JAMPILEK J; SPIEGEL S; ENRIZ RD

Synthesis and Biological Evaluation of Sphingosine Kinase 2 Inhibitors with Anti-inflammatory Activity

ARCHIV DER PHARMAZIE.; Año: 2019

CASTRO M; CAMPOS L; RODRIGUEZ Y; ALVAREZ SE

In vitro methods to study the modulation of migration and invasion by sphingosine-1- phosphate

METHODS IN MOLECULAR BIOLOGY (CLIFTON, N.J.); Año: 2018 p. 117 - 131

VETTORAZZI, MARCELA; ANGELINA, EMILIO; LIMA, SANTIAGO; GONEC, TOMAS; OTEVREL, JAN; MARVANOVA, PAVLINA; PADRTOVA, TEREZA; MOKRY, PETR; BOBAL, PAVEL; ACOSTA, LINA M.; PALMA, ALIRIO; COBO, JUSTO; BOBALOVA, JANETTE; CSOLLEI, JOZEF; MALIK, IVAN; ALVAREZ, SERGIO; SPIEGEL, SARAH; JAMPILEK, JOSEF; ENRIZ, RICARDO D.

An integrative study to identify novel scaffolds for sphingosine kinase 1 inhibitors

EUROPEAN JOURNAL OF MEDICAL CHEMISTRY; Lugar: Paris; Año: 2017

RODRIGUEZ Y; CAMPOS L; CASTRO M; ALADHAMI A; OSKERITZIAN CA; ALVAREZ SE

SPHINGOSINE-1 PHOSPHATE: A NEW MODULATOR OF IMMUNE PLASTICITY IN THE TUMOR MICROENVIRONMENT

Frontiers in Oncology; Lugar: Lausanne; Año: 2016 vol. 6

CAMPOS L; RODRIGUEZ Y; MACHADO LEOPOLDINO A; HAIT NC; LOPEZ BERGAMI P; CASTRO M; SANCHEZ ES; MACEYCKA M; SPIEGEL S; ALVAREZ SE

Filamin A Expression Negatively Regulates Sphingosine-1-Phosphate-Induced NF-kB Activation in Melanoma Cells by Inhibition of Akt Signaling

MOLECULAR AND CELLULAR BIOLOGY; Lugar: Washington; Año: 2015 vol. 36 p. 320 - 329

PRICE MM; OSKERITZIAN CA; FALANGA TY; HARIKUMAR KB; ALLEGOOD J; ALVAREZ SE; CONRAD D; RYAN JJ; MILSTIEN S; SPIEGEL S

A specific sphingosine kinase 1 inhibitor attenuates airway hyperresponsiveness and inflammation in a mast cell-dependent mouse model of allergic asthma

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY; Año: 2013 vol. 131 p. 501 - 511

ALVAREZ SE; HARIKUMAR KB; HAIT NC; ALLEGOOD J; STRUB GM; KIM EY; MACEYCKA M; JIANG H; LUO C; KORDULA T; MILSTIEN S; SPIEGEL S

Sphingosine-1-Phosphate is a missing cofactor for the E3 ubiquitin ligase TRAF2

NATURE; Lugar: Londres; Año: 2010 vol. 465 p. 1084 - 1088

OSKERITZIAN CA; ALVAREZ SE; HAIT NC; PRICE MM; MILSTIEN S; SPIEGEL S

Distinct roles of sphingosine kinases 1 and 2 in human mast cell functions.

BLOOD, THE JOURNAL OF THE AMERICAN SOCIETY OF HEMATOLOGY - PRINT; Año: 2008 p. 4193 - 4200

WORRAL D; LIANG YK; ALVAREZ SE; HOLROYD G; SPIEGEL S; PANAGOPULOS M; GRAY J; HETHERINGTON A

Involvement of sphingosine kinase in plant cell signaling.

PLANT JOURNAL; Año: 2008 p. 64 - 72

SHIDA D; FANG X; KORDULA T; TAKABE K; LEPINE S; ALVAREZ SE; MILSTIEN S; SPIEGEL S

Crosstalk Between LPA1 and EGF Receptors Mediates Upregulation of Sphingosine Kinase 1 to Promote Gastric Cancer Cell Motility and Invasion.

CANCER RESEARCH; Año: 2008 p. 6569 - 6577

MACEYCKA M*; ALVAREZ SE*; MILSTIEN S; SPIEGEL S

Filamin A Links Sphingosine Kinase 1 and S1P1 Receptor at Lamellipodia to Orchestrate Cell Migration

MOLECULAR AND CELLULAR BIOLOGY; Año: 2008 p. 5687 - 5697

MILLER AV; ALVAREZ SE; SPIEGEL S; LEBMAN DA

Sphingosine kinases and sphingosine-1-phosphate are critical for TGF-b- induced ERK1/2 activation and promotion of migration and invasion of esophageal cancer cells.

MOLECULAR AND CELLULAR BIOLOGY; Año: 2008 vol. 28 p. 4142 - 4151

GUDE DR*; ALVAREZ SE*; PAUGH SW; MITRA P; YU J; GRIFFITHS R; BARBOUR S; MILSTIEN S; SPIEGEL S

Apoptosis induces expression of sphingosine kinase 1 to release sphingosine-1-phosphate as a "come-and-get-me" signal

FASEB JOURNAL; Año: 2008 vol. 22 p. 2629 - 2638

PANAGOPULOS M; WORRAL D; LIANG YK; ALVAREZ SE; HOLROYD G; SPIEGEL S; GRAY J; HETHERINGTON A

The role of sphingosine kinase in plant cell signaling.

COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR AND INTEGRATIVE PHYSIOLOGY; Lugar: Amsterdam; Año: 2008

ALVAREZ SE; SEGUIN LR; VILLARREAL RS; NAHMIAS C; CIUFFO GM

Involvement of c-Src tyrosine kinase in SHP-1 phosphatase activation by Ang II AT2 receptors in rat fetal tissues.

JOURNAL OF CELLULAR BIOCHEMISTRY; Año: 2008 vol. 105 p. 703 - 711

VALDIVIESO AG; MARCUCCI F; TAMINELLI G; GONZALEZ GUERRICO A; ALVAREZ SE; TEIBER ML; DANKERT MA; SANTA-COLOMA TA

The expression of the mitochondrial gene MT-ND4 is downregulated in cystic fibrosis

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS; Año: 2007 p. 805 - 809

ALVAREZ SE; MILSTIEN S; SPIEGEL S

Autocrine and paracrine roles of sphingosine-1-phosphate

TRENDS IN ENDOCRINOLOGY AND METABOLISM; Año: 2007 vol. 18 p. 300 - 307

MANZUR MJ; MUÑOZ VIDELA R; LUCERO AA; JURI AYUB M; ALVAREZ SE; CIUFFO GM

Production of recombinant enzymes of wide use for research

ELECTRONIC JOURNAL OF BIOTECHNOLOGY; Año: 2006 vol. 9 p. 291 - 296

VILLARREAL RS; ALVAREZ SE; JURI AYUB M; CIUFFO GM

Angiotensin II modulates tyr-phosphorylation of IRS-4, an insulin receptor substrate, in rat liver membranes

MOLECULAR AND CELLULAR BIOCHEMISTRY; Año: 2006 vol. 293 p. 35 - 46

GOPARAJU S; JOLLY P; WATTERSON K; BEKTAS M; ALVAREZ SE; SARKAR S; MEL L; ISHI I; CHUN J; MILSTIEN S; SPIEGEL S

The S1P2 receptor negatively regulates platelet-derived growth factor-induced motility and proliferation

MOLECULAR AND CELLULAR BIOLOGY; Año: 2005 p. 4237 - 4249

ALVAREZ SE; FUENTES LB; CIUFFO GM

Angiotensin II mediates tyr-dephosphorylation in rat fetal kidney membranes.

MOLECULAR AND CELLULAR BIOCHEMISTRY; Año: 2003 p. 137 - 143

SANCHEZ S; ARCE ME; SELTZER A; ALVAREZ SE; CIUFFO GM

Localization of angiotensin II receptors in developing rat cerebellum and brainstem

THE JOURNAL OF PHYSIOLOGY; Año: 2000 p. 36 - 38

CIUFFO GM; ALVAREZ SE; FUENTES LB

Angiotensin II receptors induce tyrosine dephosphorylation in rat fetal membranes

REGULATORY PEPTIDES; Año: 1998 p. 129 - 135