Electronic spectroscopy combined and quantum chemical calculations as a new old approach to assess the oxidation of lipids

URETA M. MICAELA; BORBA, ANA; TYMCZYSZYN, E.E.; FAROUX, J.M.; GÓMEZ-ZAVAGLIA, ANDREA

Lisboa

Congreso; EuChems Chemestry Congress; 2022

European Chemical Society

In this study [1], the goal was to set up a UV-based method to assess the peroxidation products of soy lecithin liposomes. The phospholipids are the building blocks of biological membranes in both eukaryotic and prokaryotic cells as well as delivery systems for drugs, nucleic acids and nutraceuticals. Because of the presence of unsaturated fatty acids, lipid membranes are prone to peroxidation reactions (oxidative stress), leading to lipid instability and/or damage. Understanding such processes has a strong impact on physiopathological events as the products resulting from lipid peroxidation are usually associated with cellular aging, mutagenesis and carcinogenesis, among the most important ones. In addition, as lipid membranes are also used as drug delivery systems, peroxidation reactions usually lead to membrane leakage with subsequent degradation of their content, leading to a decrease in the pharmacological action of the encapsulated drugs.