Antimicrobial resistance of thermotolerant Campylobacter species isolated from humans, food-producing animals and products of animal origin: A worldwide meta-analysis

SIGNORINI, M.L.; ROSSLER, E.; DIAZ, D.C.; OLIVERO, C.R.; ROMERO SCHARPEN, A.; SOTO, L.P.; ASTESANA, D.M.; BERISVIL, A.P.; ZIMMERMANN, J.A.; FUSARI, M.L.; FRIZZO, L.S.; ZBRUN, M.V.

MICROBIAL DRUG RESISTANCE-MECHANISMS EPIDEMIOLOGY AND DISEASE

MARY ANN LIEBERT INC

Lugar: New York; Año: 2018

1076-6294

The objective of this meta-analysis was to summarize available information on the prevalence of antimicrobial resistant Campylobacter species in humans, food-producing animals and products of animal origin. A number of multilevel random-effect meta-analysis models were fitted to estimate mean occurrence rate of antimicrobial resistant thermotolerant Campylobacter and to compare them throughout the years and among the species, food-producing animals (i.e., bovine, pigs, broilers, hen, goat, sheep), country of origin, sample type, methodology to determine the antimicrobial susceptibility and thespecies of Campylobacter. Among the considered antibiotics, thermotolerantCampylobacter showed the highest resistance to tetracycline (pool estimate ?PE-= 0.493; 95% CI 0.466 ? 0.519), nalidixic acid (PE= 0.385; 95% CI 0.348 ? 0.423), and ciprofloxacin (PE= 0.376; 95% CI 0.339 - 0.415). In general, the prevalence of antimicrobial resistant Campylobacter spp. was higher in hen, broilers, and swine. C. coli showed a higher prevalence of antimicrobial resistant than C. jejuni. Independently of the antimicrobial evaluated the disk diffusion method showed higher prevalence of antimicrobial resistant Campylobacter than the methods based on the Minimum Inhibitory Concentration (MIC) estimation. The meta-analysis showed that the prevalence of antimicrobial resistant Campylobacter is relevant essentially in foods derived from hens and broilers, and it was observed worldwide. The prevalence of this pathogen is of public health importance and the increase in the prevalence of Campylobacter strains resistant to the antimicrobial of choice worsens the situation, hence, national authorities must monitor the situation in each country with the aim to establish the appropriate risk management measures.