Lactobacillus paracasei fermented milks: immunomodulatory properties of the nonbacterial fraction on gastric and intestinal epithelial cell

BENGOA A.A; ERREA A; IRAPORDA C.; RUMBO M; ABRAHAM A G; GARROTE G,L

Cancun

Congreso; Immuno Mexico 2018, XII Congress of the Latin American Association of Immunology and XXIII Congress of the Mexican Society of Immunology; 2018

Asociación Latinoamericana de Inmunología

In the present work it was demonstrated that the NBF of fermented milks obtained with L. paracasei CIDCA 8339 and L. paracasei CIDCA 83124 are able to downregulate the innate immune response on gastric and intestinal epithelial cells in vitro and that among the metabolites produce during fermentation, lactate is the main responsible of the immunomodulatory effect. The present results suggest that these fermented milks should be studied in more depth since they could be good candidates to be used as an alternative or complementary treatment for the prevention or relief of symptoms in people that suffer gastritis or inflammatory bowel disease. Regarding this, in vivo models are being carried out for a better characterization of the anti-inflammatory potential of these fermented milks as well as elucidating the main metabolites responsible for the evidenced immunomodulatory capacity.