Ureaplasma urealyticum and Micoplasma hominis sensibity to lactocin L23

M. DANIELE; L. PASCUAL; G. GERBALDO; C. ROJO; C. PÁJARO; L. BARBERIS

Huerta Grande, Córdoba

Congreso; Reunión Conjunta de Sociedades de Biología de la República Argentina,; 2008

Sociedad de Biología de la República Argentina

Ureaplasma urealyticum and Mycoplasma hominis are important pathogen microorganisms associated whit urethritis, cervicitis and cystitis. The objetive of the present work fue to study the correlation between the sensitivity to lactocin L23 and the sensitivity to antibiotics of Uu and Mh, both isolated from sexually active women. At the present time, lactobacilli constitute an alternative as preventive and biotherapeutic agents of these pathologies. The semples from endocervix were processed whit the MYCOFAST Evol 2 equipment. The antimicrobial activity was performed through an adaptation of the commercial technique. Uu was detected in 59,5 % of the 190 studied samples, Mh in the 7,6% and both Uu + Mh in 32,9%. All of the strains were inhibited by lactocin L23. 95% of the strains of Uu were inhibited with a MIC of lactocin of 80-320 UA/ml, and 78% of Mh with 320 UA/ml. A pronounced resistance to roxitromicin was observed in Mh and Uu + Mh in the assay of susceptibility to antibiotics. In conclusion, these results show the inhibitory activity of lactocin L23 upon urogenital mycoplasmas, because in presented inhibitory activity even when diluted; this is a remarkable fact keeping in mind the resistance to antibiotics of clinical use presented by these microorganisms.