Efecto de la administración de aliáceas sobre el estrés oxidativo en un modelo experimental de síndrome metabólico

VAZQUEZ, M.A.; RENNA, N.F.; GALMARINI, C.R; GONZALEZ, E.S,; LAMA, M.C.; MIATELLO, R.

Actualización en Nutricion

Año: 2008 p. 11 - 16

Onion (O): same as FFR plus onion (400 mg/kg/day) and tempol: same as FFR plus tempol as antioxidant control. The protocol lasted 14 weeks and the alliaceae and tempol were administered during the last 8 weeks. Systolic blood pressure, baseline glycemia, triglycerides, activity of NAD(P)H oxidase enzyme in aorta and TBARS plasma concentration were determined. Results: The FFR group increased their weight (p<0,01) vs C, decreasing in the G and O groups (p<0,01). The glycemia and triglyceridemia levels were higher in the FFR group vs C (p<0,001) and no changes were observed in the treated groups. The systolic blood pressure and the TBARS levels were higher in the FFR group vs C (p<0,05) while the groups under treatment modified this increase (p<0,05). The NAD(P)H oxidase activity was greater in the FFR group vs C and reverted only in the groups treated with G and tempol. Conclusions: Garlic and onion administration decreased the systolic blood pressure and the oxidative stress in the FFR model, bringing new evidence on the nutraceutical benefits in cardiovascular diseases.