Catechin and quercetin attenuate adipose inflammation in fructose-fed rats and 3T3-L1 adipocytes

VAZQUEZ PRIETO, M.; BETAIEEB, A; RODRIGUEZ LANZI, C; SOTO, V. C; PERDICARO, D; GALMARINI, C.R.; HAJ, F.; MIATELLO, R.; OTEIZA, P.

MOLECULAR NUTRITION & FOOD RESEARCH

WILEY-V C H VERLAG GMBH

Lugar: Weinheim; Año: 2015 vol. 2015 p. 622 - 633

1613-4125

This study evaluated the capacity of dietary catechin (C), quercetin (Q), and the combination of both (CQ), to attenuate adipose inflammation triggered by high fructose (HFr consumption in rats and by tumor necrosis factor alpha (TNF-) in 3T3-L1 adipocytes. Methods and results: In rats, HFr consumption for 6 wk caused dyslipidemia, insulin resistance reduced plasma adiponectin, adiposity, and adipose tissue inflammation. Dietary supplementation with 20 mg/kg/day of C, Q, and CQ improved all these parameters. In 3T3-L1