Effect of Daily Consumption of <i> Lactobacil-lus reuteri </i> CRL 1098 on Cholesterol Reduction in Hypercholesterolemic Subjects

MALPELI, AGUSTINA; TARANTO, MARÍA PÍA; CRAVERO, RICARDO C.; TAVELLA, MARINA; FASANO, VICTORIA; VICENTIN, DIMAS; FERRARI, GUILLERMINA; MAGRINI, GRACIANO; HÉBERT, ELVIRA; VALDEZ, GRACIELA FONT DE; VAREA, ANA M.; TAVELLA, JULIO M.; GONZÁLEZ, HORACIO F.

Food and Nutrition Sciences

Scientific Research Publishing

Año: 2015 vol. 06 p. 1583 - 1590

2157-944X

The effect of daily consumption of a yogurt containing Lactobacillus reuteri CRL 1098 on the lipidprofile of hypercholesterolemic subjects was evaluated by performing a prospective, randomized,double-blind, cross-over placebo controlled clinical study. Participants consumed daily a yogurtcontaining L. reuteri CRL 1098 or a placebo for four weeks, separated by a wash-out period. Totalcholesterol, triacylglycerol, high-density (HDL) and low-density (LDL) lipoprotein levels were assessedat the beginning and at the end of each period. We found a statistically significant reductionof total (−7.86 g/dl) and LDL (−7.02 g/dl) cholesterol in absolute changes (before-after) as well asa decreasing trend in the group receiving the yogurt containing L. reuteri with respect to the placebogroup, without detecting changes in HDL-cholesterol and triacylglycerol levels. Our resultssuggest that low amounts of yogurt (125 g/day) and low doses of the CRL 1098 strain (106 CFU)are sufficient to reduce total and LDL-cholesterol levels in hypercholesterolemic subjects.