Evidence of Hypocholesterolemic Effect of Lactobacillus reuteri in Hypercholesterolemic Mice

TARANTO, MARIA PIA; MEDICI, MARTA; PERDIGON, GABRIELA; RUIZ HOLGADO, AIDA; FONT DE VALDEZ, GRACIELA

JOURNAL OF DAIRY SCIENCE

American Dairy Science Association

Lugar: USA; Año: 1999 vol. 81 p. 2336 - 2340

0022-0302

Swiss Albino mice were fed a diet enriched with fat to produce hypercholesterolemia. The further administration of Lactobacillus reuteri CRL 1098 (104cells/d) to hypercholesterolemic mice for 7 d decreased total cholesterol by 38%, producing serum cholesterol concentrations similar to that of the control group (67.4 mg/ml). This low dose of L. reuteri caused a 40% reduction in triglycerides and a 20% increase in the ratio of high density lipoprotein to low density lipoprotein without bacterial translocation of the native  microflora into the spleen and liver. These data suggest that L. reuteri CRL 1098 is an effective hypocholesterolemic adjuvant at a low cell concentration for miceLactobacillus reuteri CRL 1098 (104cells/d) to hypercholesterolemic mice for 7 d decreased total cholesterol by 38%, producing serum cholesterol concentrations similar to that of the control group (67.4 mg/ml). This low dose of L. reuteri caused a 40% reduction in triglycerides and a 20% increase in the ratio of high density lipoprotein to low density lipoprotein without bacterial translocation of the native  microflora into the spleen and liver. These data suggest that L. reuteri CRL 1098 is an effective hypocholesterolemic adjuvant at a low cell concentration for mice