MODULATION OF INTESTINAL MICROBIOTA AND IMMUNO-METABOLIC PARAMETERS BY CALORIC RESTRICTION AND LACTIC ACID BACTERIA

EMANUEL FABERSANI; MATIAS RUSSO; ANTONELA MARQUEZ; CLAUDIA ABEIJÓN-MUKDSI; ROXANA MEDINA; PAOLA GAUFFIN

FOOD RESEARCH INTERNATIONAL

ELSEVIER SCIENCE BV

Lugar: Amsterdam; Año: 2018

0963-9969

The objective of this work was to evaluate the effect of a caloricrestriction diet with and without the administration of Lactobacillus fermentumCRL1446, Lactobacillus casei CRL431 and Lactococcus lactis CRL1434, onimmune-metabolic parameters and the composition of intestinal microbiota inmice. The supplementation of the CR diet with L. fermentum CRL1446 showed a bifidogeniceffect and was able to maintain the abundance of the genus Lactobacillus overtime. On the other hand, this strain showed hypocholesterolemic andhypoglycemic properties as well as inducing a decrease in plasma leptin levels.L. casei CRL431 administration increased the abundance of the Lactobacillus,which would improve the absorption of nutrients from the diet. This strainrestores glucose values decreased by the diet in addition to inducing anincrease in leptin and cytokines. Lac. lactis CRL1434 showed greaterimmunomodulatory capacity, without significantly affecting the composition ofthe intestinal microbiota. It had hypoglycemic properties and induced adecrease in leptin concentrations. L. fermentum CRL1446 and Lac. lactis CRL1434could be potentially probiotic strains useful to correct the immuno-metabolicalterations associated with obesity, while L. casei CRL431 is a more suitablestrain to be used in cases of malnutrition where it is sought to improve the absorptionof nutrients and protection against infections, in addition to the stimulationof the immune system.