Antimicrobial activity of carbohydrate chitosan derivatives

DIAZ VERGARA, L.; ARATA BADANO, J.; BRESER, L.; PORPORATTO, C.; PEREYRA, C.; CAVAGLIERI, L.; MONTENEGRO, M.A.

Mar del Plata

Congreso; XVI SIMPOSIO LATINOAMERICANO DE POLÍMEROS Y XIV CONGRESO IBEROAMERICANO DE POLÍMEROS; 2018

Instituto de Ciencia y Tecnología en Materiales (INTEMA)

Chitosan (Ch) is a polysaccharide composed of β-(1→4)-N-acetyl-2-amino-2-deoxy-D-glucose and 2-amino-2-deoxy-D-glucose obtained from the alkaline deacetylation of chitin. It is a natural, biocompatible, biodegradable, antioxidant, antimicrobial, non-toxic, mucoadhesive, antitumor compound. Antimicrobial activity has been attributed to the molecular weight (MW) and deacetylation degrees (DD). However, this property is limited by the Ch low solubility. The aims of this study were to evaluate the antimicrobial glucose derivative (ChG) and lactose derivatives (ChLac48 and ChLac60), against Staphylococcus aureus, Escherichia coli and Enterococcus faecalis. The antimicrobial activity of ChG (278 KDa, 66.8% DD) was reduced compared to the native Ch, while ChLac48 and ChLac60 conserved the activity against all the evaluated bacteria. The difference can be attributed to the diminution of %DD in ChG, while ChLac48 and ChLac60 the increased reaction time decreased the MW. In conclusion the derivatives with lactose presented similar antimicrobial activity as native Ch, making them promising for their use in food and pharmaceutics products.