ZAMPONI, EMILIANO; PIGINO, GUSTAVO F.

Protein Misfolding, Signaling Abnormalities and Altered Fast Axonal Transport: Implications for Alzheimer and Prion Diseases

Frontiers in Cellular Neuroscience; Lugar: Lausanne; Año: 2019 vol. 13

BIGNANTE, ELENA ANAHI; PONCE, NICOLÁS ERIC; HEREDIA, FLORENCIA; MUSSO, JULIANA; KRAWCZYK, MARÍA C.; MILLÁN, JULIETA; PIGINO, GUSTAVO F.; INESTROSA, NIBALDO C.; BOCCIA, MARIANO M.; LORENZO, ALFREDO

APP/Go protein Gβγ-complex signaling mediates Aβ degeneration and cognitive impairment in Alzheimer's disease models

NEUROBIOLOGY OF AGING; Año: 2018 vol. 64 p. 44 - 57

ZAMPONI, EMILIANO; ZAMPONI, NAHUEL; COSKUN, PINAR; QUASSOLLO, GONZALO; LORENZO, ALFREDO; CANNAS, SERGIO A.; PIGINO, GUSTAVO; CHIALVO, DANTE; GARDINER, KATHELEEN; BUSCIGLIO, JORGE; HELGUERA, PABLO

Nrf2 stabilization prevents critical oxidative damage in Down syndrome cells

AGING CELL; Lugar: Londres; Año: 2018

EMILIANO ZAMPONI; FIAMMA BURATTI; GABRIEL CATALDI; HECTOR HUGO CAICEDO; YUYU SONG; LISA M. JUNGBAUER; MARY J. LADU; MARIANO BISBAL; ALFREDO LORENZO; JIYAN MA; PABLO R. HELGUERA; GERARDO A. MORFINI; SCOTT T. BRADY; GUSTAVO F. PIGINO

Prion protein inhibits fast axonal transport through a mechanism involving Casein kinase 2

PLOS ONE; Lugar: San Francisco; Año: 2017

GERARDO A. MORFINI; NADINE SCHMIDT; CARINA WEISSMAN; GUSTAVO PIGINO; STEFAN KINS

Conventional kinesin: Biochemical heterogeneity and functional implications in health and disease

BRAIN RESEARCH BULLETIN; Lugar: Amsterdam; Año: 2016

GERARDO A. MORFINI; DARYL A. BOSCO; HANNAH BROWN; RODOLFO GATTO; AGNIESZKA KAMINSKA; YUYU SONG; LINDA MOLLA; LISA BAKER; M. NATALIA MARANGONI; SARAH BERTH; EHSAN TAVASSOLI; CAROLINA BAGNATO; ASHUTOSH TIWARI; LAWRENCE J. HAYWARD; GUSTAVO F. PIGINO; D. MARTIN WATTERSON; CHUN-FANG HUANG; GARY BANKER; ROBERT H. BROWN JR; SCOTT T. BRADY

Inhibition of Fast Axonal Transport by Pathogenic SOD1 Involves Activation of p38 MAP Kinase

PLOS ONE; Lugar: San Francisco; Año: 2013

YUAN-SHIH HU; NANCY LONG; GUSTAVO PIGINO; SCOTT T. BRADY; ORLY LAZAROV

Molecular Mechanisms of Environmental Enrichment: Impairments in Akt/GSK3b, Neurotrophin-3 and CREB Signaling

PLOS ONE; Lugar: San Francisco; Año: 2013

LUDOVICO CANTUTI CASTELVETRI; MARIA I. GIVOGRI; AMY HEBERT; BENJAMIN SMITH; YUYU SONG; AGNIESZKA KAMINSKA; AURORA LOPEZ-ROSAS; GERARDO MORFINI; GUSTAVO PIGINO; MARK SANDS; SCOTT T. BRADY; ERNESTO R. BONGARZONE

The Sphingolipid Psychosine Inhibits Fast Axonal Transport in Krabbe Disease by Activation of GSK3
and Deregulation of Molecular Motors

JOURNAL OF NEUROSCIENCE; Lugar: Washington; Año: 2013

KANAAN NM, MORFINI G, PIGINO G, LAPOINTE NE, ANDREADIS A, SONG Y, LEITMAN E, BINDER LI, BRADY ST.

Phosphorylation in the amino terminus of tau prevents inhibition of anterograde axonal transport.

NEUROBIOLOGY OF AGING; Lugar: Amsterdam; Año: 2012 vol. 33 p. 826 - 827

KANAAN NM, PIGINO GF, BRADY ST, LAZAROV O, BINDER LI, MORFINI GA.

Axonal degeneration in Alzheimer's disease: When signaling abnormalities meet the axonal transport system.

EXPERIMENTAL NEUROLOGY; Lugar: Amsterdam; Año: 2012 p. 4 - 14

KANAAN NM, MORFINI GA, LAPOINTE NE, PIGINO GF, PATTERSON KR, SONG Y, ANDREADIS A, FU Y, BRADY ST, BINDER LI.

Pathogenic forms of tau inhibit kinesin-dependent axonal transport through a mechanism involving activation of axonal phosphotransferases.

JOURNAL OF NEUROSCIENCE; Lugar: Washington; Año: 2011 vol. 31 p. 9858 - 9868

HU YS, XU P, PIGINO G, BRADY ST, LARSON J, LAZAROV O.

Complex environment experience rescues impaired neurogenesis, enhances synaptic plasticity, and attenuates neuropathology in familial Alzheimer's disease-linked APPswe/PS1DeltaE9 mice.

FASEB JOURNAL; Lugar: Bethesda; Año: 2010 vol. 24 p. 1667 - 1681

LAPOINTE NE, MORFINI G, PIGINO G, GAISINA IN, KOZIKOWSKI AP, BINDER LI, BRADY ST.

The amino terminus of tau inhibits kinesin-dependent axonal transport: implications for filament toxicity.

JOURNAL OF NEUROSCIENCE RESEARCH; Lugar: New York; Año: 2009 vol. 87 p. 440 - 451

MORENO H, YU E, PIGINO G, HERNANDEZ AI, KIM N, MOREIRA JE, SUGIMORI M, LLINÁS RR.

Synaptic transmission block by presynaptic injection of oligomeric amyloid beta.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA; Lugar: Washington DC, USA; Año: 2009 vol. 106 p. 5901 - 5906

PIGINO G, MORFINI G, ATAGI Y, DESHPANDE A, YU C, JUNGBAUER L, LADU M, BUSCIGLIO J, BRADY S.

Disruption of fast axonal transport is a pathogenic mechanism for intraneuronal amyloid beta.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA; Lugar: Washington DC, USA; Año: 2009 vol. 106 p. 5907 - 5912

MORFINI GA, YOU YM, POLLEMA SL, KAMINSKA A, LIU K, YOSHIOKA K, BJÖRKBLOM B, COFFEY ET, BAGNATO C, HAN D, HUANG CF, BANKER G, PIGINO G, BRADY ST.

Pathogenic huntingtin inhibits fast axonal transport by activating JNK3 and phosphorylating kinesin.

NATURE NEUROSCIENCE.; Lugar: Londres; Año: 2009 vol. 12 p. 864 - 871

MORFINI GA, BURNS M, BINDER LI, KANAAN NM, LAPOINTE N, BOSCO DA, BROWN RH JR, BROWN H, TIWARI A, HAYWARD L, EDGAR J, NAVE KA, GARBERRN J, ATAGI Y, SONG Y, PIGINO G, BRADY ST

Axonal transport defects in neurodegenerative diseases.

JOURNAL OF NEUROSCIENCE; Lugar: Washington; Año: 2009 vol. 29 p. 12776 - 12786

DEBOER SR, YOU Y, SZODORAI A, KAMINSKA A, PIGINO G, NWABUISI E, WANG B, ESTRADA-HERNANDEZ T, KINS S, BRADY ST, MORFINI G. SOURCE

Conventional kinesin holoenzymes are composed of heavy and light chain homodimers.

BIOCHEMISTRY; Lugar: Washington; Año: 2008 vol. 47 p. 4535 - 4543

MORFINI G, PIGINO G, MIZUNO N, KIKKAWA M, BRADY ST.

Tau binding to microtubules does not directly affect microtubule-based vesicle motility.

Journal of Neuroscience Research; Lugar: Boston; Año: 2007 vol. 85 p. 2620 - 2630

MORFINI G, PIGINO G, OPALACH K, SERULLE Y, MOREIRA JE, SUGIMORI M, LLINÁS RR, BRADY ST.

1-Methyl-4-phenylpyridinium affects fast axonal transport by activation of caspase and protein kinase C.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA; Lugar: Washington DC, USA; Año: 2007 vol. 104 p. 2442 - 2447

SERULLE Y, MORFINI G, PIGINO G, MOREIRA JE, SUGIMORI M, BRADY ST, LLINÁS RR.

1-Methyl-4-phenylpyridinium induces synaptic dysfunction through a pathway involving caspase and PKCdelta enzymatic activities.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA; Lugar: Washington DC, USA; Año: 2007 vol. 104 p. 2437 - 2441

LAZAROV O, MORFINI GA, PIGINO G, GADADHAR A, CHEN X, ROBINSON J, HO H, BRADY ST, SISODIA SS.

Impairments in fast axonal transport and motor neuron deficits in transgenic mice expressing familial Alzheimer's disease-linked mutant presenilin 1.

JOURNAL OF NEUROSCIENCE; Lugar: Washington; Año: 2007 vol. 27 p. 7011 - 7020

MORFINI G, PIGINO G, BRADY ST.

Approaches to kinesin-1 phosphorylation.

METHODS IN MOLECULAR BIOLOGY (CLIFTON, N.J.); Lugar: New York; Año: 2007 vol. 392 p. 51 - 69

MORFINI G, PIGINO G, SZEBENYI G, YOU Y, POLLEMA S, BRADY ST.

JNK mediates pathogenic effects of polyglutamine-expanded androgen receptor on fast axonal transport.

NATURE NEUROSCIENCE.; Lugar: Londres; Año: 2006 vol. 7 p. 907 - 916

MORFINI G, PIGINO G, BRADY ST.

Polyglutamine expansion diseases: failing to deliver.

TRENDS IN MOLECULAR MEDICINE; Lugar: Amsterdam; Año: 2005 vol. 11 p. 64 - 70

HELGUERA P, PELSMAN A, PIGINO G, WOLVETANG E, HEAD E, BUSCIGLIO J.

ets-2 promotes the activation of a mitochondrial death pathway in Down's syndrome neurons.

JOURNAL OF NEUROSCIENCE; Lugar: Washington; Año: 2005 vol. 25 p. 2295 - 2303

MORFINI G, SZEBENYI G, BROWN H, PANT HC, PIGINO G, DEBOER S, BEFFERT U, BRADY ST.

A novel CDK5-dependent pathway for regulating GSK3 activity and kinesin-driven motility in neurons

EMBO JOURNAL; Lugar: Londres; Año: 2004 vol. 23 p. 2235 - 2245

PIGINO G, MORFINI G, PELSMAN A, MATTSON MP, BRADY ST, BUSCIGLIO J.

Alzheimer's presenilin 1 mutations impair kinesin-based axonal transport.

JOURNAL OF NEUROSCIENCE; Lugar: Washington; Año: 2003 vol. 23 p. 4499 - 4508

JORGE BUSCIGLIO, ALEJANDRA PELSMAN, CAINE WONG, GUSTAVO PIGINO, MENGLAN YUAN, HIROSHI MORI, BRUCE A. YANKNER

Altered Metabolism of the Amyloid β Precursor Protein Is Associated with Mitochondrial Dysfunction in Down's Syndrome

NEURON; Lugar: United States; Año: 2002 vol. 33 p. 677 - 688

MORFINI G, PIGINO G, BEFFERT U, BUSCIGLIO J, BRADY ST.

Fast axonal transport misregulation and Alzheimer's disease.

NEUROMOLECULAR MEDICINE; Lugar: Oregon; Año: 2002 vol. 2 p. 89 - 99

PIGINO G, PELSMAN A, MORI H, BUSCIGLIO J.

Presenilin-1 mutations reduce cytoskeletal association, deregulate neurite growth, and potentiate neuronal dystrophy and tau phosphorylation.

JOURNAL OF NEUROSCIENCE; Lugar: Washington; Año: 2001 vol. 21 p. 834 - 842

PAGLINI G, PIGINO G, KUNDA P, MORFINI G, MACCIONI R, QUIROGA S, FERREIRA A, CÁCERES A.

Evidence for the participation of the neuron-specific CDK5 activator P35 during laminin-enhanced axonal growth.

JOURNAL OF NEUROSCIENCE; Lugar: Washington; Año: 1998 vol. 18 p. 9858 - 9869

GUSTAVO PIGINO, GABRIELA PAGLINI, LUIS ULLOA, JESÚS AVILA AND ALFREDO CÁCERES

Analysis of the expression, distribution and function of cyclin dependent kinase 5 (cdk5) in developing cerebellar macroneurons

JOURNAL OF CELL SCIENCE; Lugar: Cambridge; Año: 1997 vol. 110 p. 257 - 270