INVESTIGADORES
PIGINO Gustavo Fernando
artículos
Título:
Axonal transport defects in neurodegenerative diseases.
Autor/es:
MORFINI GA, BURNS M, BINDER LI, KANAAN NM, LAPOINTE N, BOSCO DA, BROWN RH JR, BROWN H, TIWARI A, HAYWARD L, EDGAR J, NAVE KA, GARBERRN J, ATAGI Y, SONG Y, PIGINO G, BRADY ST
Revista:
JOURNAL OF NEUROSCIENCE
Editorial:
SOC NEUROSCIENCE
Referencias:
Lugar: Washington; Año: 2009 vol. 29 p. 12776 - 12786
ISSN:
0270-6474
Resumen:
Adult-onset neurodegenerative diseases (AONDs) comprise a heterogeneous
group of neurological disorders characterized by a progressive,
age-dependent decline in neuronal function and loss of selected neuronal
populations. Alterations in synaptic function and axonal connectivity
represent early and critical pathogenic events in AONDs, but molecular
mechanisms underlying these defects remain elusive. The large size and
complex subcellular architecture of neurons render them uniquely
vulnerable to alterations in axonal transport (AT). Accordingly,
deficits in AT have been documented in most AONDs, suggesting a common
defect acquired through different pathogenic pathways. These
observations suggest that many AONDs can be categorized as
dysferopathies, diseases in which alterations in AT represent a critical
component in pathogenesis. Topics here address various molecular
mechanisms underlying alterations in AT in several AONDs. Illumination
of such mechanisms provides a framework for the development of novel
therapeutic strategies aimed to prevent axonal and synaptic dysfunction
in several major AONDs.