Neuroprotective effects of bioavailable phenolic compounds from Ilex paraguariensiws on the brain of mice with lung adenocarcinoma

CITTADINI M.C.; REPOSSI G. ; ALBRECHT C.; DI PAOLA NARANJO R.D.; MIRANDA A.D.; DE PASCUAL TERESA S.; SORIA E.A.

Congreso; VII Congrelso Internacional Ciencia y Tecnología de los Alimentos; 2018

Ministerio de Ciencia y Tecnología - Gobierno de Córdoba - UNC

Lung carcinoma is one of the most common cancers worldwide and has a high human mortality. Recently, we showed that it produces paraneoplastic syndrome and neurological impairment, with Ilex paraguariensis extract (IP) exerting palliative effects due to its content of bioactive phenolic compounds. It is possible, therefore, that these diet agents can arrive at the brain and exert neuroprotection, after the oral intake of IP. In this study, the main aim was to investigate the preclinical protective role of bioavailable IP compounds on the telencephalon and diencephalon in lung adenocarcinoma-bearing male BALB/C mice treated for 3 weeks with 0-100 IP mg/Kg/day. HPLC-UV revealed the presence of chlorogenic acid and quercetin in these brain regions and at other sites in an IP dose-dependent manner. Chlorogenic acid was the major compound found in brain, whereas quercetin was observed at the diencephalon to a lesser extent. Both compounds were involved in IP dose-dependent diencephalic interleukin-6 reduction. Histological analysis suggested improved cellular neuroprotection with less apoptosis in chlorogenic-exposed areas. Taken together, chlorogenic acid and quercetin from Ilex paraguariensis, a dietary plant, were bioavailable and bioactive in brain, thereby attenuating lung cancer-related neuroinflammation and damage. These findings strengthen the rationale for future efforts to develop plant-based chemopreventive strategies to control or delay cancer progression and thus improve patient outcomes.