Breast-milk derived potential probiotics as strategy for the management of childhood obesity

ODDI, S.; HUBER, P.; ROCHA FARIA DUQUE, A.L.; VINDEROLA, G.; SIVIERI, K.

FOOD RESEARCH INTERNATIONAL

ELSEVIER SCIENCE BV

Año: 2020 vol. 137

0963-9969

Obesity and overweight, and their concomitant metabolic diseases, emerge as one of the most severe healthproblems in the world. Prevention and management of obesity are proposed to begin early in childhood, whenprobiotics may have a role. The Simulator of the Human Intestinal Microbial Ecosystem (SHIME®), in a dynamicvalidated in vitro system able to simulate the different parts of the gastrointestinal tract, has proven to be usefulin analyzing the human intestinal microbial community. L. plantarum 73a and B. animalis subsp. lactis INL1, twostrains isolated from breast milk, were assayed in the SHIME® using the fecal microbiota of an obese child.L. plantarum 73a alone or in combination with B. animalis subsp. lactis INL1 demonstrated survival capacity in theSHIME® system. The administration of both strains increased the alpha diversity of the microbiota and reducedthe levels of the phylum Proteobacteria. In particular, the genera Escherichia, Shigella, and Clostridium_sensu_stricto_1 were significantly reduced when both strains were administered. The increase of Proteobacteria phylumis generally associated with the microbiota of obese people. Escherichia and Shigella can be involved ininflammation-dependent adiposity and insulin resistance. L. plantarum 73a supplementation reduced ammoniaproduction. L. plantarum 73a alone or in combination with B. animalis subsp. lactis INL1 are potential probioticcandidates for the management of infant obesity.