CONICET | Buscador de Institutos y Recursos Humanos

Poultry production is linked to veterinary drug use to treat diseases.Few ectoparasitic compounds are approved for poultry. Fipronil is a pesticidewidely used in agriculture. It is also a drug authorized to control ectoparasitesin small animals and, in some countries, in cattle. There has been evidence offipronil extra-label use in laying hens, mainly to control the red mite Dermanyssusgallinae. Fipronil?s popularity is due to its high toxicity to invertebrates. Itcould be metabolized to more toxic metabolites that potentially damage humanhealth. In the present study, we carry out a quantitative exposure assessmentand risk characterization for fipronil residues in laying hen eggs for local consumptionin five cities of Buenos Aires province in Argentina, namely, Azul,Balcarce, Juarez, Chaves, and Tandil. Consumption surveys and egg samplingwere conducted for three summer periods. Eggswere analyzed by UFLC-MS-MS.Fipronil prevalence, residue concentrations, residue stability to cooking methods,egg consumption, among the most important variables were modeled. Theresults indicated that 20.7% of samples contained fipronil residues. The highestresidue was fipronil sulfone metabolite. Fipronil concentrations quantifiedranged between 10 and 2510 ppb (median value = 150 ppb). When eggs werecooked, fipronil residues were stable. The exposure assessment and risk characterizationrevealed that the highest probability of consuming eggs with fipronilresidues above the admissible limits was for young adults (20.8%), followed bybabies (16.9%), young children (16.4%), children (13.4%), teenagers (10.3%), olderadults (9.41%), and adults (8.65%). These results suggest an unacceptable riskassociated with egg consumption with fipronil residues for all age groups.

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