PROBIEN   20416
INSTITUTO DE INVESTIGACION Y DESARROLLO EN INGENIERIA DE PROCESOS, BIOTECNOLOGIA Y ENERGIAS ALTERNATIVAS
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
Patagonian native plant extract can protect cells of arsenic toxicity
Autor/es:
SOTOMAYOR, V; BONGIOVANNI, G.A.
Lugar:
Aveiro
Reunión:
Simposio; 9th International Symposium on Environmental Geochemistry; 2012
Resumen:
Chronic toxic effects of arsenic resulting from drinking water are a human health problem,
especially in South-America and Asia, where there is a correlation between oxidative stress,
tumor promotion and arsenic exposure has been observed. In order to examine their protective
potential, the antioxidant activity in different Patagonian native plants extracts (Argentina) were
determined in vitro in the Vero cell line (mammalian kidney). Experimentally, hydroperoxide,
caspase activity and ROS level were assayed to evaluate the properties of eighteen extracts
compared by ANOVA followed by the LSD Fisher test. Data showed that arsenite was prooxidant
in Vero cells in a time- and dose-dependent manner (logistic regression). Five plant
extracts were found to counter the oxidative stress response. Therefore, antioxidant activities
are being purified since they may have a protective activity against arsenite-induced renal injury.