EFFECT OF EXCESS IODIDE INTAKE ON SALIVARY GLANDS IN A SWISS 2 ALBINO MICE MODEL

ROSS, GLORIA ROMINA ; FABERSANI, EMANUEL; RUSSO, MATIAS ; GOMEZ, ALBA; JAPAZE, HUGO; GONZÁLEZ, SILVIA NELINA; GAUFFIN CANO, PAOLA

BioMed Research International

Hindawi Publishing Corporation

Año: 2017

Iodine is an important micronutrient required for nutrition. Excess iodine have adverse effects on thyroid, but there are no enough information regarding their effect on salivary glands. In addition to food and iodized salt, skin disinfectants and maternal nutritional supplements contain iodide so its intake could be excessive during pregnancy, lactation and infancy. The aim of this work was to evaluate the effect of excess iodide ingestion on salivary glands during mating, gestation, lactation and post-weaning period in mouse. During assay mice were allocated into groups: Control and Treatment groups (received distilled water with NaI 1mg/mL). Water intake, glandular weight and histology, were analyzed. Treatment groups showed an increase in glandular weight and a significantly (p < 0.05) higher water intake than Control groups. It was observed lymphocyte infiltration in animals of Treatment groups, while there was no infiltration in glandular sections of Control groups. Results demonstrated that could exist a negative relationship between iodide excess and salivary glands. This work is a novel evidence that, as any way, high levels of iodide intake could induce mononuclear infiltration in salivary glands. These results should be consider, especially in pregnant/lactating women, to which a highest iodine intake it is usually recommended.