Antimicrobial Resistance of Thermotolerant Campylobacter Species Isolated from Humans, Food-Producing Animals, and Products of Animal Origin: A Worldwide Meta-Analysis

SIGNORINI, MARCELO L.; ROSSLER, EUGENIA; DÍAZ DAVID, DIEGO C.; OLIVERO, CAROLINA R.; ROMERO-SCHARPEN, ANALÍA; SOTO, LORENA P.; ASTESANA, DIEGO M.; BERISVIL, AYELEN P.; ZIMMERMANN, JORGE A.; FUSARI, MARCIA L.; FRIZZO, LAUREANO S.; ZBRUN, MARÍA V.

MICROBIAL DRUG RESISTANCE-MECHANISMS EPIDEMIOLOGY AND DISEASE

MARY ANN LIEBERT INC

Lugar: New York; Año: 2018

1076-6294

The objective of this meta-analysis was to summarize available information on the prevalence of antimicrobialresistantCampylobacter species in humans, food-producing animals, and products of animal origin. A numberof multilevel random-effect meta-analysis models were fitted to estimate mean occurrence rate of antimicrobialresistantthermotolerant Campylobacter and to compare them throughout the years and among the species,food-producing animals (i.e., bovine, pigs, broilers, hen, goat, and sheep), country of origin, sample type, methodologyto determine the antimicrobial susceptibility, and the species of Campylobacter. Among the consideredantibiotics, thermotolerant Campylobacter showed the highest resistance to tetracycline (pool estimate [PE] =0.493; 95% CI 0.466?0.519), nalidixic acid (PE = 0.385; 95% CI 0.348?0.423), and ciprofloxacin (PE = 0.376;95% CI 0.339?0.415). In general, the prevalence of antimicrobial-resistant Campylobacter spp. was higherin hen, broilers, and swine. Campylobacter coli showed a higher prevalence of antimicrobial resistance thanCampylobacter jejuni. Independent of the antimicrobial evaluated, the disk diffusion method showed higherprevalence of antimicrobial-resistant Campylobacter than the methods based on the minimum inhibitory concentrationestimation. The meta-analysis showed that the prevalence of antimicrobial-resistant Campylobacter isrelevant essentially in foods derived from hens and broilers, and it was observed worldwide. The prevalence ofthis pathogen is of public health importance and the increase in the prevalence of Campylobacter strains resistantto the antimicrobial of choice worsens the situation, hence, national authorities must monitor the situation in eachcountry with the aim to establish the appropriate risk management measures.