Nanoferulic: From a by‐product of the beer industry toward the regeneration of the skin

BUCCI, PAULA LORENA; SANTOS, MARÍA VICTORIA; MONTANARI, JORGE; ZARITZKY, NOEMI

Journal of Cosmetic Dermatology

John Wiley & Sons

Lugar: NewJersey; Año: 2020 vol. 0 p. 1 - 7

1473-2130

AbstractBackground: Brewers´ spent grain (BSG) is one of the most abundant by-products ofthe beer industry and causes serious environmental problems. Ferulic acid (FA) is anantioxidant with potential cosmeceutical applications. FA was extracted from BSG,developing a method of high extraction performance in order to be encapsulated inultradeformable liposomes (Nanoferulic, NF).Aims: To obtain a product with high added value such as FA, from a residue currentlyunderused, using simple and economical chemical methods. To load FA into a nanosystem designed for the topical route, its encapsulation has the purpose to take profitfrom its photoprotective, anti-inflammatory, and antioxidant properties in the deeplayers of the skin.Methods: Ferulic acid was obtained from dried BSG using acid and basic treatmentsin series. NF was prepared by lipid film resuspension of a solution containing FA obtained from BSG. Size and Z-potential were determined. Cytotoxicity was assessedin vitro. Skin penetration was assessed by NF determination at different skin depthsand by confocal microscopy.Results: The yield of the extraction process was 0.43% on a dry basis. Encapsulationrendered liposomes of around 140 nm with 92% of encapsulation efficiency. No toxicity was observed in all the tested concentrations. Successful results were obtainedfrom the regeneration studies.Conclusions: It was possible to develop a nanosystem containing FA, generating ahigh-value commercial input for the pharmaceutical and cosmeceutical industry. Theuse of BSG generated in industrial scale would help to reduce the volume of highlypolluting waste.