INVESTIGADORES
ALONSO Silvia Del Valle
artículos
Título:
Toward biomedical application of amino-functionalized silicon nanoparticles
Autor/es:
LILLO, CRISTIAN R.; NATALIA CALIENNI, MARIÁ; GOROJOD, ROXANA M.; RIVAS AIELLO, MARIÁ BELÉN; RODRIGUEZ SARTORI, DAMIÁN; PRIETO, MARIÁ JIMENA; ALONSO, SILVIA DEL V.; KOTLER, MÓNICA L.; GONZALEZ, MÓNICA C.; MONTANARI, JORGE
Revista:
NANOMEDICINE
Editorial:
FUTURE MEDICINE LTD
Referencias:
Año: 2018 vol. 13 p. 1349 - 1370
ISSN:
1743-5889
Resumen:
Silicon blue-emitting nanoparticles (NPs) are promising effectors for photodynamic therapy and radiotherapy, because of their production of reactive oxygen species (ROS) upon irradiation. Results: Amino-functionalized silicon NPs (NH2SiNP) were intrinsically nontoxic below 100 μg/ml in vitro (on two tumor cell lines) and in vivo (zebrafish larvae and embryos). NH2SiNP showed a moderate effect as a photosensitizer for photodynamic therapy and reduced ROS generation in radiotherapy, which could be indicative of a ROS scavenging effect. Encapsulation of NH2SiNP into ultradeformable liposomes improved their skin penetration after topical application, reaching the viable epidermis where neoplastic events occur. Conclusion: Subsequent derivatizations after amino-functionalization and incorporation to nanodrug delivery systems could expand the spectrum of the biomedical application of these kind of silicon NPs.
