INVESTIGADORES
VIRKEL Guillermo Leon
artículos
Título:
Depletion of moxidectin tissue residues in sheep
Autor/es:
LIFSCHITZ A, IMPERIALE F, VIRKEL G, MUÑOZ COBEÑAS M, SCHERLING N, DELAY R, LANUSSE C.
Revista:
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
Editorial:
AMER CHEMICAL SOC
Referencias:
Lugar: Washington; Año: 2000 vol. 48 p. 6011 - 6015
ISSN:
0021-8561
Resumen:
The pattern of tissue depletion of moxidectin (MXD) subcutaneously
administered to sheep was characterized in this study. MXD concentration
profiles were determined in muscle, fat, and liver and at the site of
injection following administration of a formulation combining MXD (0.5%
w/v) with a standard 6 in 1 clostridial vaccine. Thirty-five (35)
parasite-free Lincoln sheep were treated with the MXD injectable
formulation at a dose rate of 0.2 mg of MXD/kg of live weight,
administered subcutaneously on the inner surface of the thigh. Treated
animals were sacrificed in randomly selected groups of six sheep weekly
from day 21 until day 49 post-treatment. Three nontreated animals were
sacrificed to obtain blank tissue samples to validate the analytical
methodology. MXD concentration profiles were determined by a validated
HPLC analytical method using fluorescence detection. MXD has an adequate
pattern of absorption, based on the low residual concentrations found
in the injection site area at all sampling intervals. Muscle samples
showed the lowest MXD concentrations throughout the study period. The
highest MXD concentrations at all sampling times were measured in the
adipose tissue, indicating that fat is a target tissue for MXD. MXD
concentrations in all of the tissues analyzed were below the accepted
maximum limit of residue at 21 days post-treatment.