INVESTIGADORES
VIRKEL Guillermo Leon
artículos
MIRÓ, MARÍA VICTORIA; COSTA-JÚNIOR, LIVIO MARTINS; LLOBERAS, MERCEDES; CARDOZO, PATRICIA; LANUSSE, CARLOS; VIRKEL, GUILLERMO; LIFSCHITZ, ADRIÁN
Phytochemicals in Gastrointestinal Nematode Control: Pharmacokinetic–Pharmacodynamic Evaluation of the Ivermectin plus Carvone Combination
Animals; Año: 2023 vol. 13
LARSEN, KAREN; ICHINOSE, PAULA; FERNÁNDEZ-SAN JUAN, ROCÍO; LIFSCHITZ, ADRIÁN; VIRKEL, GUILLERMO
Effects of acaricides on the activities of monooxygenases in bovine liver microsomes
JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS; Año: 2023
ICHINOSE, PAULA; MIRÓ, MARÍA VICTORIA; LARSEN, KAREN; LANUSSE, CARLOS; LIFSCHITZ, ADRIÁN; VIRKEL, GUILLERMO
Medication with fenbendazole in feed: plasma concentrations and effects on hepatic xenobiotic metabolizing enzymes in swine
VETERINARY RESEARCH COMMUNICATIONS; Año: 2023
LARSEN, K.; LIFSCHITZ, A.; FERNÁNDEZ SAN JUAN, R.; VIRKEL, G.
Metabolic stability of glyphosate and its environmental metabolite (aminomethylphosphonic acid) in the ruminal content of cattle
FOOD ADDITIVES AND CONTAMINANTS; Lugar: Londres; Año: 2022
TAVARES, CAIO P; SOUSA, ISABELLA C; GOMES, MATHEUS N; MIRÓ, VICTORIA; VIRKEL, GUILLERMO; LIFSCHITZ, ADRIAN; COSTA-JUNIOR, LIVIO M
Combination of cypermethrin and thymol for control of Rhipicephalus microplus: Efficacy evaluation and description of an action mechanism
Ticks and Tick-borne Diseases; Lugar: Berlín; Año: 2022 vol. 13
MIRÓ, MARÍA VICTORIA; COSTA-JÚNIOR, LIVIO MARTINS; ALVAREZ, LUIS IGNACIO; LANUSSE, CARLOS; VIRKEL, GUILLERMO; LIFSCHITZ, ADRIÁN
Pharmacological characterization of geraniol in sheep and its potential use in the control of gastrointestinal nematodes
Veterinary and Animal Science; Lugar: Amsterdam; Año: 2022 vol. 18
LUQUE, S.; LLOBERAS, M.; CARDOZO, P.; VIRKEL, G.; FARIAS, C.; VIVIANI, P.; LANUSSE, C.; ALVAREZ, L.; LIFSCHITZ, A.
Combined moxidectin-levamisole treatment against multidrug-resistant gastrointestinal nematodes: A four-year efficacy monitoring in lambs
VETERINARY PARASITOLOGY; Año: 2021 vol. 290
MIRÓ, MARÍA VICTORIA; ROCHA E SILVA, CAROLINA ROCHA; VIVIANI, PAULA; LUQUE, SONIA; LLOBERAS, MERCEDES; COSTA-JÚNIOR, LIVIO MARTINS; LANUSSE, CARLOS; VIRKEL, GUILLERMO; LIFSCHITZ, ADRIÁN
Combination of bioactive phytochemicals and synthetic anthelmintics: In vivo and in vitro assessment of the albendazole-thymol association
VETERINARY PARASITOLOGY; Lugar: Amsterdam; Año: 2020 vol. 281
MIRÓ, VICTORIA; LIFSCHITZ, ADRIAN; VIVIANI, PAULA; ROCHA, CAROLINA; LANUSSE, CARLOS; COSTA, LIVIO; VIRKEL, GUILLERMO
In vitro inhibition of the hepatic S-oxygenation of the anthelmintic albendazole by the natural monoterpene thymol in sheep
XENOBIOTICA; Año: 2020 vol. 50 p. 408 - 414
BALLENT, M.; CANTON, C.; DOMINGUEZ, P.; BERNAT, G.; LANUSSE, C.; VIRKEL, G.; LIFSCHITZ, A.
Pharmacokinetic-pharmacodynamic assessment of the ivermectin and abamectin nematodicidal interaction in cattle
VETERINARY PARASITOLOGY; Año: 2020 vol. 279
MIRÓ, M.V.; LUQUE, S.; CARDOZO, P.; LLOBERAS, M.; SOUSA, D.M.; SOARES, A.M.S.; COSTA-JUNIOR, L.M.; VIRKEL, G.L.; LIFSCHITZ, ADRIAN L.
Plant-Derived Compounds as a Tool for the Control of Gastrointestinal Nematodes: Modulation of Abamectin Pharmacological Action by Carvone
Frontiers in Veterinary Science; Lugar: Lauzana; Año: 2020 vol. 7
VIRKEL, GUILLERMO; BALLENT, MARIANA; LANUSSE, CARLOS; LIFSCHITZ, ADRIAN
Role of ABC transporters in veterinary medicine: pharmaco-toxicological implications
CURRENT MEDICINAL CHEMISTRY.; Año: 2019 vol. 26 p. 1251 - 1269
MATÉ, L.; GIANTIN, M.; VIVIANI, P.; BALLENT, M.; TOLOSI, R.; LIFSCHITZ, A.; LANUSSE, C.; DACASTO, M.; VIRKEL, G.
Effects of fenbendazole and triclabendazole on the expression of cytochrome P450 1A and flavin-monooxygenase isozymes in bovine precision-cut liver slices
The Veterinary Journal; Año: 2019 vol. 245 p. 61 - 69
BALLENT, MARIANA; MATÉ, MARIA LAURA; DOMINGUEZ, PAULA; VIRKEL, GUILLERMO; ALBÉRICH, MELANIE; LESPINE, ANNE; LANUSSE, CARLOS; LIFSCHITZ, ADRIAN LUIS
Assessment of the long-acting ivermectin formulation in sheep: Further insight into potential pharmacokinetic interactions
JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS; Año: 2019 vol. 42 p. 189 - 196
CEBALLOS, LAURA; CANTON, CANDELA; CADENAZZI, GABRIELA; VIRKEL, GUILLERMO; DOMINGUEZ, PAULA; MORENO, LAURA; LANUSSE, CARLOS; ALVAREZ, LUIS
Oxfendazole kinetics in pigs: In vivo assessment of its pattern of accumulation in Ascaris suum
EXPERIMENTAL PARASITOLOGY; Año: 2019 vol. 199 p. 52 - 58
LARSEN, KAREN E.; LIFSCHITZ, ADRIÁN L.; LANUSSE, CARLOS E.; VIRKEL, GUILLERMO L.
In vitro and in vivo effects of chlorpyrifos and cypermethrin on blood cholinesterases in sheep
JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS; Año: 2019 vol. 42 p. 548 - 555
VIVIANI, P.; LIFSCHITZ, A.L.; LUQUE, S.E.; LLOBERAS, M.M.; MATÉ, M.L.; CARDOZO, P.A.; LANUSSE, C.E.; VIRKEL, G.L.
Pharmacologic interaction between oxfendazole and triclabendazole: In vitro biotransformation and systemic exposure in sheep
EXPERIMENTAL PARASITOLOGY; Año: 2019 vol. 204
BALLENT, M.; VIVIANI, P.; IMPERIALE, F.; DOMINGUEZ, P.; HALWACHS, S.; MAHNKE, H.; HONSCHA, W.; LANUSSE, C.; VIRKEL, G.; LIFSCHITZ, A.
Pharmacokinetic assessment of the monepantel plus oxfendazole combined administration in dairy cows
JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS; Año: 2018 vol. 41 p. 292 - 300
VIVIANI, P.; LIFSCHITZ, A.L.; MATÉ, M.L.; GARCÍA, J.P.; LANUSSE, C.E.; VIRKEL, G.L.
Assessment of the pharmacological interactions between the nematodicidal fenbendazole and the flukicidal triclabendazole: In vitro studies with bovine liver microsomes and slices
JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS; Año: 2018 vol. 41 p. 476 - 484
LANUSSE, CARLOS; CANTON, CANDELA; VIRKEL, GUILLERMO; ALVAREZ, LUIS; COSTA-JUNIOR, LIVIO; LIFSCHITZ, ADRIAN
Strategies to Optimize the Efficacy of Anthelmintic Drugs in Ruminants
TRENDS IN PARASITOLOGY; Año: 2018 vol. 34 p. 664 - 682
CEBALLOS, L.; CANTON, C.; CADENAZZI, G.; LARSEN, K.; VIRKEL, G.; MORENO, L.; FAIRWEATHER, I.; LANUSSE, C.; ALVAREZ, L.
Understanding the main route of drug entry in adult Fasciola hepatica: Further insights into closantel pharmacological activity
EXPERIMENTAL PARASITOLOGY; Año: 2017 vol. 181 p. 23 - 29
VIVIANI, P.; LIFSCHITZ, A.; GARCÍA, J.; MATÉ, L.; QUIROGA, M.; LANUSSE, C.; VIRKEL, G.
Assessment of liver slices for research on metabolic drug-drug interactions in cattle
XENOBIOTICA; Lugar: London; Año: 2017 vol. 47 p. 933 - 942
MATÉ, M. L.; GEARY, T.; MACKENZIE, C.; LANUSSE, C.; VIRKEL, G.
Species differences in hepatic biotransformation of the anthelmintic drug flubendazole
JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS; Año: 2017 vol. 40 p. 493 - 499
LARSEN, K., LIFSCHITZ, A., LANUSSE, C., VIRKEL, G.
The herbicide glyphosate is a weak inhibitor of acetylcholinesterase in rats
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY; Lugar: Amsterdam; Año: 2016 vol. 45 p. 41 - 44
WILKENS, M.R. , MATÉ, L.M., SCHNEPEL, N., KLINGER, S., MUSCHER-BANSE, A.S., BALLENT, M., VIRKEL, G., LIFSCHITZ, A.L.
Influence of 25-hydroxyvitamin D3 and 1,25-dihydroxyvitamin D3 on expression of P-glycoprotein and cytochrome P450 3A in sheep
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY; Lugar: Amsterdam; Año: 2016 vol. 164 p. 271 - 276
BALLENT, M. , VIRKEL, G., MATÉ, L., VIVIANI, P., LANUSSE, C., LIFSCHITZ, A.
Hepatic biotransformation pathways and ruminal metabolic stability of the novel anthelmintic monepantel in sheep and cattle
JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS; Lugar: Londres; Año: 2016 vol. 39 p. 488 - 496
MATÉ ML, BALLENT M, LARSEN K, LIFSCHITZ A, LANUSSE C, VIRKEL G.
Gene expression and enzyme function of two cytochrome P450 3A isoenzymes in rat and cattle precision cut liver slices
XENOBIOTICA; Año: 2015 vol. 45 p. 563 - 570
ALVAREZ, L. , SUAREZ, G., CEBALLOS, L., MORENO, L., CANTON, C., LIFSCHITZ, A., MATÉ, L., BALLENT, M., VIRKEL, G., LANUSSE, C.
Integrated assessment of ivermectin pharmacokinetics, efficacy against resistant Haemonchus contortus and P-glycoprotein expression in lambs treated at three different dosage levels
VETERINARY PARASITOLOGY; Lugar: Amsterdam; Año: 2015 vol. 210 p. 53 - 63
LLOBERAS, M., ALVAREZ, L., ENTROCASSO, C., BALLENT, M., VIRKEL, G., LUQUE, S., LANUSSE, C., LIFSCHITZ, A.
Comparative pharmacokinetic and pharmacodynamic response of single and double intraruminal doses of ivermectin and moxidectin in nematode-infected lambs
NEW ZEALAND VETERINARY JOURNAL; Año: 2015 vol. 63 p. 227 - 234
LAURA MORENO, PAULA DOMINGUEZ, CRISTINA FARIAS, LUCILA CANTON, GUILLERMO VIRKEL, LAURA MATÉ, LAURA CEBALLOS, CARLOS LANUSSE, AND LUIS ALVAREZ
Ivermectin Pharmacokinetics, Metabolism, and Tissue/Egg Residue Profiles in Laying Hens
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY; Lugar: Washington; Año: 2015 vol. 63 p. 10327 - 10332
LARSEN, K.; NAJLE, R.; LIFSCHITZ, A.; MATÉ, L.; LANUSSE, C.; VIRKEL, G.
Effects of Sublethal Exposure to a Glyphosate-Based Herbicide Formulation on Metabolic Activities of Different Xenobiotic-Metabolizing Enzymes in Rats
INTERNATIONAL JOURNAL OF TOXICOLOGY; Lugar: Thousand Oaks, California.; Año: 2014 vol. 33 p. 307 - 318
BALLENT, M., MATÉ, L., VIRKEL, G., SALLOVITZ, J., VIVIANI, P., LANUSSE, C., LIFSCHITZ, A.
Intestinal drug transport: Ex vivo evaluation of the interactions between ABC transporters and anthelmintic molecules
JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS; Lugar: Londres; Año: 2014 vol. 37 p. 332 - 337
LIFSCHITZ A, BALLENT M, VIRKEL G, SALLOVITZ J, VIVIANI P, LANUSSE C.
Accumulation of monepantel and its sulphone derivative in tissues of nematode location in sheep: Pharmacokinetic support to its excellent nematodicidal activity
VETERINARY PARASITOLOGY; Lugar: Amsterdam; Año: 2014 vol. 203 p. 120 - 126
VIRKEL, G.; LIFSCHITZ, A.; SALLOVITZ, J.; MATÉ, L.; FARÍAS, C.; LANUSSE, C.
In vitro and in vivo assessment of the benzydamine-mediated interference with the hepatic S-oxidation of the anthelmintic albendazole in sheep
JOURNAL OF SMALL RUMINANT RESEARCH; Lugar: Amsterdam; Año: 2014 vol. 120 p. 142 - 149
LLOBERAS, M.; ALVAREZ, L.; ENTROCASSO, C.; VIRKEL, G.; BALLENT, M.; MATÉ, L.; LANUSSE, C.; LIFSCHITZ, A.
Comparative tissue pharmacokinetics and efficacy of moxidectin, abamectin and ivermectin in lambs infected with resistant nematodes: Impact of drug treatments on parasite P-glycoprotein expression.
International Journal for Parasitology: Drugs and Drug resistance; Lugar: Amsterdam; Año: 2013 vol. 3 p. 20 - 27
BALLENT, M.; WILKENS, M.R.; MATÉ, L.; MUSCHER, A.S.; VIRKEL, G.; SALLOVITZ, J.; SCHRÖDER, B.; LANUSSE, C.; LIFSCHITZ, A.
P-glycoprotein in sheep liver and small intestine: gene expression and transport efflux activity.
JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS; Lugar: Londres; Año: 2013 vol. 36 p. 576 - 582
CEBALLOS, L.; VIRKEL, G.; ELISSONDO, C.; CANTON, C.; CANEVARI, J.; MURNO, G.; DENEGRI, G.; LANUSSE, C.; ALVAREZ, L.
A pharmacology-based comparison of the activity of albendazole and flubendazole against Echinococcus granulosus metacestode in sheep.
ACTA TROPICA; Lugar: Amsterdam; Año: 2013 vol. 127 p. 216 - 225
LLOBERAS M, ALVAREZ L, ENTROCASSO C, VIRKEL G, LANUSSE C, LIFSCHITZ A.
Measurement of ivermectin concentrations in target worms and host gastrointestinal tissues: influence of the route of administration on the activity against resistant Haemonchus contortus in lambs
EXPERIMENTAL PARASITOLOGY; Lugar: Amsterdam; Año: 2012 vol. 131 p. 304 - 309
BALLENT, M.; LIFSCHITZ, A.; VIRKEL, G.; SALLOVITZ, J.; MATÉ, L.; LANUSSE, C.
In vivo and ex vivo assessment of the interaction between ivermectin and danofloxacin in sheep
The Veterinary Journal; Lugar: Amsterdam; Año: 2012 vol. 192 p. 422 - 427
SALLOVITZ, J.M.; NEJAMKIN, P.; LIFSCHITZ, A.L.; VIRKEL G.L.; IMPERIALE, F.A.; LANUSSE, C.E.
Comparative in vitro characterization of moxidectin and doramectin percutaneous absorption through bovine skin
JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS; Lugar: Londres; Año: 2012 vol. 35 p. 184 - 192
SCARCELLA S, LAMENZA P, VIRKEL G, SOLANA H.
Expression differential of microsomal and cytosolic glutathione-S-transferases in Fasciola hepatica resistant at triclabendazole
MOLECULAR AND BIOCHEMICAL PARASITOLOGY; Lugar: Amsterdam; Año: 2012 vol. 181 p. 37 - 39
LARSEN K, NAJLE R, LIFSCHITZ A, VIRKEL G.
Effects of sub-lethal exposure of rats to the herbicide glyphosate in drinking water: Glutathione transferase enzyme activities, levels of reduced glutathione and lipid peroxidation in liver, kidneys and small intestine
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY; Lugar: Amsterdam; Año: 2012 vol. 34 p. 811 - 818
MATÉ, M.L.; LIFSCHITZ, A.; SALLOVITZ, J.; BALLENT, M.; MUSCHER, A.S.; WILKENS, M.R.; SCHRÖDER, B.; LANUSSE, C.; VIRKEL, G.
Cytochrome P450 3A expression and function in liver and intestinal mucosa from dexamethasone-treated sheep
JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS; Lugar: Londres; Año: 2012 vol. 35 p. 319 - 328
VIRKEL, G.; CARLETTI, M.; CANTIELLO, M.; DELLA DONNA, L.; GARDINI, G.; NEBBIA, C.
Characterization of xenobiotic metabolizing enzymes in bovine small intestinal mucosa
JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS; Año: 2010 vol. 33 p. 295 - 303
MATÉ, L.; VIRKEL, G.; LIFSCHITZ, A.; SALLOVITZ, J.; BALLENT, M; LANUSSE, C.
Phase 1 and phase 2 metabolic activities along the small intestine in adult male sheep
JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS; Año: 2010 vol. 33 p. 537 - 545
LIFSCHITZ, A.; ENTROCASSO, C.; ALVAREZ, L.; LOBERAS, M.; BALLENT, M.; MANAZZA, J.; VIRKEL, G. ; BORDA, B.; LANUSSE, C.
Interference with P-glycoprotein improves ivermectin activity against adult resistant nematodes in sheep
VETERINARY PARASITOLOGY; Año: 2010 vol. 172 p. 291 - 298
BALLENT, M.; LIFSCHITZ, A.; VIRKEL, G.; MATÉ, L.; LANUSSE, C.
Pretreatment with the inducers rifampicin and phenobarbital alters ivermectin gastrointestinal disposition
JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS; Lugar: Londres; Año: 2010 vol. 33 p. 252 - 259
SOLANA, H.; SCARCELLA, S.; VIRKEL, G.; CERIANI, C.; RODRIGUEZ, J.; LANUSSE, C.
Albendazole enantiomeric metabolism and binding to cytosolic proteins in the liver fluke Fasciola hepatica
VETERINARY RESEARCH COMMUNICATIONS; Año: 2009 vol. 33 p. 163 - 173
VIRKEL, G., LIFSCHITZ, A., SALLOVITZ, J., BALLENT, M., SCARCELLA, S.,LANUSSE, C.
Inhibition of cytochrome P450 activity enhances the systemic availability of triclabendazole metabolites in sheep
JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS; Año: 2009 vol. 32 p. 79 - 86
CAPECE, B.; VIRKEL, G.; LANUSSE, C.
Enantiomeric behaviour of albendazole and fenbendazole sulfoxides in domestic animals: Pharmacological implications
The Veterinary Journal; Año: 2009 vol. 181 p. 241 - 250
LIFSCHITZ A, VIRKEL G, BALLENT M, SALLOVITZ J, LANUSSE C.
Combined use of ivermectin and triclabendazole in sheep: In vitro and in vivo characterisation of their pharmacological interaction
The Veterinary Journal; Año: 2009 vol. 182 p. 261 - 268
SOLANA, H.; SCARCELLA, S.; VIRKEL, G.; CERIANI, C.; RODRÍGUEZ, J.; LANUSSE, C.
Albendazole enantiomeric metabolism and binding to cytosolic proteins in the liver fluke Fasciola hepatica
VETERINARY RESEARCH COMMUNICATIONS; Año: 2008 vol. 33 p. 163 - 173
ALVAREZ, L.; LIFSCHITZ, A.; ENTROCASSO, C.; MANAZZA, J.; MOTTIER, L.; BORDA, B.; VIRKEL, G.; LANUSSE, C.
Evaluation of the interaction between ivermectin and albendazole following their combined use in lambs.
JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS; Año: 2008 vol. 31 p. 230 - 239
MATÉ, L.; VIRKEL, G.; LIFSCHITZ, A.; BALLENT, M.; LANUSSE C.
Hepatic and extra-hepatic metabolic pathways involved in flubendazole biotransformation in sheep
BIOCHEMICAL PHARMACOLOGY; Lugar: Amsterdam; Año: 2008 vol. 76 p. 773 - 783
ENTROCASSO, C.; ALVAREZ, L.; MANAZZA, J.; LIFSCHITZ, A.; BORDA, B.; VIRKEL, G.; MOTTIER, L.; LANUSSE, C.
Clinical efficacy assessment of the albendazole-ivermectin combination in lambs parasitized with resistant nematodes
VETERINARY PARASITOLOGY; Año: 2008 vol. 155 p. 249 - 256
BRENNAN, G.; FAIRWEATHER, I.; TRUDGETT, A.; HOEY, E.; MCCOY; MCCONVILLE, M.; MEANEY, M.; ROBINSON, M.; MCFERRAN, N.; RYAN, L; LANUSSE, C.; MOTTIER, L.; ALVAREZ, L.; SOLANA, H.; VIRKEL, G.; BROPHY, P.
Understanding triclabendazole resistance
EXPERIMENTAL AND MOLECULAR PATHOLOGY.; Año: 2007 vol. 82 p. 104 - 109
BALLENT, M.,; LIFSCHITZ, A.; VIRKEL, G.; SALLOVITZ, J.; LANUSSE, C.
Involvement of P-glycoprotein on ivermectin kinetic behaviour in sheep: itraconazole-mediated changes on gastrointestinal disposition
JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS; Año: 2007 vol. 30 p. 242 - 348
LIFSCHITZ, A.; VIRKEL, G.; BALLENT, M.; SALLOVITZ, J.; IMPERIALE, F.; PIS, A.; LANUSSE, C.
Ivermectin (3.15%) long-acting formulations in cattle: absorption pattern and pharmacokinetic considerations.
VETERINARY PARASITOLOGY; Año: 2007 vol. 147 p. 303 - 310
LIFSCHITZ, A.; BALLENT, M.; VIRKEL, G.; SALLOVITZ, J.; LANUSSE, C.
Sex-related differences in the gastrointestinal disposition of ivermectin in the rat: P-glycoprotein involvement and itraconazole modulation.
JOURNAL OF PHARMACY AND PHARMACOLOGY; Año: 2006 vol. 58 p. 1055 - 1062
VIRKEL, G.; LIFSCHITZ, A.; SALLOVITZ, J.; PIS, A.; LANUSSE, C.
Assessment of the main metabolism pathways for the flukicidal compound triclabendazole in sheep.
JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS; Año: 2006 vol. 29 p. 213 - 223
BALLENT, M.; LIFSCHITZ, A.; VIRKEL, G.; SALLOVITZ, J.; LANUSSE, C.
Modulation of the P-glycoprotein-mediated intestinal secretion of ivermectin: in vitro and in vivo assessments.
Drug Metabolism and Disposition; Año: 2006 vol. 34 p. 457 - 463
BALLENT, M., LIFSCHITZ, A., VIRKEL, G., LANUSSE, C.
Implicancias fisio-farmacológicas de la glicoproteína-P en animales domésticos
ANALECTA VETERINARIA; Año: 2005 vol. 25 p. 36 - 47
LIFSCHITZ, A.; VIRKEL, G.; BALLENT, M.; SALLOVITZ, J.; PIS, A.; LANUSSE, C.
Moxidectin and ivermectin metabolic stability in sheep ruminal and abomasal contents
JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS; Año: 2005 vol. 28 p. 411 - 418
ALVAREZ, L.; SOLANA, H.; MOTTIER, L.; VIRKEL, G.; FAIRWEATHER, I.; LANUSSE, C.
Altered drug influx/efflux and enhanced metabolic activity in triclabendazole-resistant liver flukes
PARASITOLOGY; Año: 2005 vol. 131 p. 501 - 510
SALLOVITZ, J.; LIFSCHITZ, A.; IMPERIALE, F.; VIRKEL, G.; LARGHI, J.; LANUSSE, C.
Doramectin concentration profiles in the gastrointestinal tract of topically-treated calves: Influence of animal licking restriction
VETERINARY PARASITOLOGY; Año: 2005 vol. 133 p. 61 - 70
IMPERIALE, F., LIFSCHITZ, A., SALLOVITZ, J., VIRKEL, G., LANUSSE, C.
Comparative depletion of ivermectin and moxidectin milk residues in dairy sheep after oral and subcutaneous administration
Journal of Dairy Research; Año: 2004 vol. 71 p. 427 - 433
MOTTIER L, VIRKEL G, SOLANA H, ALVAREZ L, SALLES J, LANUSSE C
Triclabendazole biotransformation and comparative diffusion of the parent drug and its oxidized metabolites into Fasciola hepatica
XENOBIOTICA; Año: 2004 vol. 34 p. 1043 - 1057
MORENO, L., ALVAREZ, L., MOTTIER, L., VIRKEL, G., SANCHEZ BRUNI, S., LANUSSE, C.
Integrated pharmacological assessment of flubendazole potential for use in sheep: Disposition kinetics, liver metabolism and parasite diffusion ability
JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS; Año: 2004 vol. 27 p. 299 - 308
MOTTIER, L., MORENO, L., ALVAREZ, L., VIRKEL, G., LANUSSE, C.
Measurement of triclabendazole and its metabolites in liver flukes: Method development and full validation
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS; Lugar: Amsterdam; Año: 2004 vol. 35 p. 991 - 999
VIRKEL, G., LIFSCHITZ, A., SALLOVITZ, J., PIS, A., LANUSSE, C.
Comparative hepatic and extrahepatic enantioselective sulfoxidation of albendazole and fenbendazole in sheep and cattle
Drug Metabolism and Disposition; Año: 2004 vol. 32 p. 536 - 544
VIRKEL, G., LIFSCHITZ, A., SALLOVITZ, J., INZA, G., LANUSSE, C.
Effect of the ionophore antibiotic monensin on the ruminal biotransformation of benzimidazole anthelmintics
The Veterinary Journal; Lugar: Amsterdam; Año: 2004 vol. 167 p. 265 - 271
LIFSCHITZ, A.L., VIRKEL, G.L., SALLOVITZ, J.M., PIS, A., IMPERIALE, F.A., LANUSSE, C.E.
Loperamide modifies the tissue disposition kinetics of ivermectin in rats
JOURNAL OF PHARMACY AND PHARMACOLOGY; Año: 2004 vol. 167 p. 265 - 271
SALLOVITZ JM, LIFSCHITZ A, IMPERIALE F, VIRKEL G, LANUSSE C.
A detailed assessment of the pattern of moxidectin tissue distribution after pour-on treatment in calves
JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS; Año: 2003 vol. 26 p. 95 - 103
VIRKEL, G., IMPERIALE, F., LIFSCHITZ, A., PIS, A., ALVAREZ, A., MERINO, G., PRIETO, J., LANUSSE, C.
Effect of amphiphilic surfactant agents on the gastrointestinal absorption of albendazole in cattle
Biopharmaceutics and Drug Disposition; Año: 2003 vol. 24 p. 95 - 103
SALLOVITZ, J., LIFSCHITZ, A., IMPERIALE, F., PIS, A., VIRKEL, G., LANUSSE, C.E.
Breed differences on the plasma availability of moxidectin administered pour-on to calves
The Veterinary Journal; Lugar: Amsterdam; Año: 2002 vol. 164 p. 47 - 53
VIRKEL, G., LIFSCHITZ, A., PIS, A., LANUSSE, C.
In vitro ruminal biotransformation of benzimidazole sulphoxide anthelmintics: Enantioselective sulphoreduction in sheep and cattle
JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS; Año: 2002 vol. 25 p. 15 - 23
LIFSCHITZ, A., VIRKEL, G., SALLOVITZ, J., IMPERIALE, F., PIS, A., LANUSSE, C.
Loperamide-induced enhancement of moxidectin availability in cattle
JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS; Año: 2002 vol. 25 p. 111 - 120
CRISTOFOL, C., VIRKEL, G., ALVAREZ, L., SÁNCHEZ, S., ARBOIX, M., LANUSSE, C.
Albendazole sulphoxide enantiomeric ratios in plasma and target tissues after intravenous administration of ricobendazole to cattle
JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS; Año: 2001 vol. 24 p. 117 - 124
CRISTOFOL, C., VIRKEL, G., ALVAREZ, L., ARBOIX, M., LANUSSE, C.E.
Comparative disposition of ricobendazole enantiomers after intravenous and subcutaneous administration of a racemic formulation to calves
Biopharmaceutics and Drug Disposition; Año: 2000 vol. 21 p. 303 - 311
LIFSCHITZ A, IMPERIALE F, VIRKEL G, MUÑOZ COBEÑAS M, SCHERLING N, DELAY R, LANUSSE C.
Depletion of moxidectin tissue residues in sheep
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY; Lugar: Washington; Año: 2000 vol. 48 p. 6011 - 6015
VIRKEL G, LIFSCHITZ A, SORACI A, SANSINANEA A, LANUSSE C.
Enantioselective liver microsomal sulphoxidation of albendazole in cattle: Effect of nutritional status
XENOBIOTICA; Año: 2000 vol. 30 p. 381 - 393
LIFSCHITZ, A., VIRKEL, G., SALLOVITZ, J., SUTRA, J.F., GALTIER, P., ALVINERIE, M., LANUSSE, C.
Comparative distribution of ivermectin and doramectin to parasite location tissues in cattle
VETERINARY PARASITOLOGY; Lugar: Amsterdam; Año: 2000 vol. 87 p. 327 - 338