Comparative pharmacokinetic and pharmacodynamic response of single and double intraruminal doses of ivermectin and moxidectin in nematode-infected lambs

LLOBERAS, M; ALVAREZ, L; ENTROCASSO, C; BALLENT, M; VIRKEL, G; LUQUE, S; LANUSSE, C; LIFSCHITZ, A

NEW ZEALAND VETERINARY JOURNAL

NEW ZEALAND VETERINARY ASSOC INC

Año: 2015

0048-0169

To compare the pharmacokinetics, distribution and efficacy (pharmacodynamic response) of intraruminal ivermectin (IVM) and moxidectin (MXD) administered at 0.2 and 0.4 mg/kg to naturally nematode-infected lambs, and to determine the ex vivo accumulation of these anthelmintics by Haemonchus contortus. METHODS: Romney Marsh lambs, naturally infected with IVM-resistant H. contortus, were allocated to treatment groups based on faecal nematode egg counts. They received 0.2 or 0.4 mg/kg