A high oxfendazole dose to control porcine cysticercosis: Pharmacokinetics and tissue residue profiles

MORENO, L; LOPEZ-URBINA, L; FARIAS, C; DOMINGUE, G; DONADEU, M; DUNGU, B; GARCIA, H; GOMEZ-PUERTA, L; LANUSSE, C; GONZALEZ, A

FOOD AND CHEMICAL TOXICOLOGY

PERGAMON-ELSEVIER SCIENCE LTD

Lugar: Amsterdam; Año: 2012 vol. 50 p. 3819 - 3825

0278-6915

Oxfendazole (OFZ) is efficacious for porcine cysticercosis at 30 mg/kg. OFZ is not registered to be used at 29 this dose. The assessment of the OFZ and metabolites [(fenbendazole sulphone (FBZSO2), fenbendazole 30 (FBZ)] plasma pharmacokinetic and tissue residue profiles after its oral administration to pigs and the 31 withdrawal period for human consumption were reported. Forty-eight pigs allocated into two groups 32 received OFZ (30 mg/kg) orally as a commercial (CF) or as experimental formulation (SMF). Samples 33 (blood, muscle, liver, kidney and fat) were collected over 30 days post-treatment and analyzed by HPLC. 34 OFZ was the main compound recovered in plasma, followed by FBZSO2 and low FBZ concentrations. OFZ 35 AUC0-LOQ (209.9 ± 33.9 lgh/ml) and Cmax (5.40 ± 0.65 lg/ml) parameters for the CF tended to be higher 36 than those for the SMF (AUC0-LOQ: 159.4 ± 18.3 lg h/ml, Cmax: 3.80 ± 0.35 lg/ml). The highest total resi- 37 due (OFZ + FBZSO2 + FBZ) concentrations were quantified in liver, followed by kidney, muscle and fat tis- 38 sue. FBZSO2 residue levels were the highest found in muscle (0.68 ± 0.39 lg/g) and fat (0.69 ± 0.39 lg/g). 39 In liver and kidney the highest residues corresponded to FBZ (5.29 ± 4.36 lg/g) and OFZ (2.86 ± 0.75 lg/ 40 g), respectively. A withdrawal time of 17 days post-treatment was established before tissues are deliv- 41 ered for human consumption.