INVESTIGADORES
LANUSSE Carlos Edmundo
artículos
Título:
Pattern of ivermectin (sheep) and doramectin (cattle) residues in muscular tissue from different anatomical locations.
Autor/es:
MORENO, L.;; ALVAREZ, L.; CEBALLOS, L; SANCHEZ BRUNI, S; LANUSSE, C.
Revista:
FOOD ADDITIVES AND CONTAMINANTS
Editorial:
Taylor and Francis Ltd
Referencias:
Año: 2008 p. 406 - 412
ISSN:
0265-203X
Resumen:
Abstract
This trial reports comparative drug residual concentrations in muscular tissue obtained from various anatomical locations
after subcutaneous administration of ivermectin (IVM) to sheep and topical treatment with doramectin (DRM) to calves at
recommended therapeutic dose rates. Seven muscle samples from different anatomical locations (rhomboideus,
supraspinatus, semitendinosus, gluteus medius, longissimus dorsi thoracis, intercostales and diaphragma) were collected
at several post-treatment sampling times. Samples were frozen at ?20C until analyzed by HPLC. The highest IVM residual
concentrations in muscular tissue from the different locations were found at 15 days post-treatment in sheep. Although the
highest IVM mean concentrations were measured at 15 (16.85.17 ng g1) and 20 (10.54.06 ng g1) days postadministration
in the intercostales muscles, at 30 days post-administration, the IVM concentration in this location was
similar to that measured in the rhomboideus and diaphragma muscles. DRM residual concentrations were quantified in
muscular tissue from all anatomical locations after topical administration to calves. Maximum residue level was observed
at 10 days post-treatment in all anatomical sites. The diaphragma muscle showed the highest DRM residue levels at
2 (22.04.35 ng g1), 5 (45.23.78 ng g1) and 10 (57.99.57 ng g1) days post-treatment in calves. These results
demonstrated that the pattern of residue depletion from muscular tissue may differ according to its anatomical locations
and/or physiological role. This should be considered in implementing residue control strategies in meat safety assurance
for human consumption.
C until analyzed by HPLC. The highest IVM residual
concentrations in muscular tissue from the different locations were found at 15 days post-treatment in sheep. Although the
highest IVM mean concentrations were measured at 15 (16.85.17 ng g1) and 20 (10.54.06 ng g1) days postadministration
in the intercostales muscles, at 30 days post-administration, the IVM concentration in this location was
similar to that measured in the rhomboideus and diaphragma muscles. DRM residual concentrations were quantified in
muscular tissue from all anatomical locations after topical administration to calves. Maximum residue level was observed
at 10 days post-treatment in all anatomical sites. The diaphragma muscle showed the highest DRM residue levels at
2 (22.04.35 ng g1), 5 (45.23.78 ng g1) and 10 (57.99.57 ng g1) days post-treatment in calves. These results
demonstrated that the pattern of residue depletion from muscular tissue may differ according to its anatomical locations
and/or physiological role. This should be considered in implementing residue control strategies in meat safety assurance
for human consumption.
1) and 20 (10.54.06 ng g1) days postadministration
in the intercostales muscles, at 30 days post-administration, the IVM concentration in this location was
similar to that measured in the rhomboideus and diaphragma muscles. DRM residual concentrations were quantified in
muscular tissue from all anatomical locations after topical administration to calves. Maximum residue level was observed
at 10 days post-treatment in all anatomical sites. The diaphragma muscle showed the highest DRM residue levels at
2 (22.04.35 ng g1), 5 (45.23.78 ng g1) and 10 (57.99.57 ng g1) days post-treatment in calves. These results
demonstrated that the pattern of residue depletion from muscular tissue may differ according to its anatomical locations
and/or physiological role. This should be considered in implementing residue control strategies in meat safety assurance
for human consumption.
1), 5 (45.23.78 ng g1) and 10 (57.99.57 ng g1) days post-treatment in calves. These results
demonstrated that the pattern of residue depletion from muscular tissue may differ according to its anatomical locations
and/or physiological role. This should be considered in implementing residue control strategies in meat safety assurance
for human consumption.
Keywords: Drug residues, muscle, anatomical locations, ivermectin, doramectin, sheep, cattleDrug residues, muscle, anatomical locations, ivermectin, doramectin, sheep, cattle