INVESTIGADORES
VENTURA Alejandra Cristina
congresos y reuniones científicas
Título:
Mathematical modeling applied to cancer progression: understanding the role of RhoC GTPase in aggressive phenotypes of breast cancer
Autor/es:
ALEJANDRA C VENTURA; JACQUES-A. SEPULCHRE; MEI WU; ZHIFEN WU; JORGE R TREDICCE; SOFIA D MERAJVER
Lugar:
Ann Arbor, USA
Reunión:
Simposio; University of Michigan Comprehensive Cancer Center Annual Fall Symposium; 2006
Institución organizadora:
University of Michigan, Comprehensive Cancer Center
Resumen:
The most damaging change during cancer progression is the growth of metastases. The protein RhoC GTPase was found to be crucial in that process in different cancers, particularly, in a highlyaggressive form of breast cancer. RhoC is a molecular switch cycling between inactive (GDP-bound) and active (GTP-bound) states, tightly regulated by several regulatory proteins. We have developed a dual mathematical-experimental approach to understand this cycle and its deregulation in breast cancer cells in comparison with normal ones. A major impact of this work is to quantitatively predict the effects of drugs targeted against RhoC in cancer.
