INVESTIGADORES
VENTURA Alejandra Cristina
congresos y reuniones científicas
Título:
Mathematical modeling of cancer progression: understanding the role of the RhoC GTPase on-off switch in aggressive phenotypes of breast cancer
Autor/es:
ALEJANDRA C VENTURA; JACQUES-A. SEPULCHRE; MEI WU; ZHIFEN WU; JORGE R TREDICCE; SOFIA D MERAJVER
Lugar:
San Diego, USA
Reunión:
Otro; 2006 Summer School - Quantitative Approaches to Gene Regulatory Systems; 2006
Institución organizadora:
Center for Theoretical Biological Physics (CTBP),
Resumen:
The most damaging change during cancer progression is the growth of metastases. RhoC GTPase was found to be crucial in that process in different cancers, particularly, in a highly aggressive form of breast cancer. RhoC is a molecular switch cycling between inactive (GDP-bound) and active (GTP-bound) states, tightly regulated by several regulatory proteins. We have developed a dual mathematical-experimental approach to understand this cycle and its deregulation in cancer cells in comparison with normal ones.
