Constrains on a module?s effective sensitivity by the input and readout dynamic range

EDGAR ALTSZYLER; ALEJANDRA C VENTURA; ALEJANDRO COLMAN-LERNER; ARIEL CHERNOMORETZ

Santa Fe, New Mexico

Conferencia; The Seventh q-bio Conference; 2013

Many features of biochemical modules should be analyzed in a proper context to gain insight into how such a component behaves under physiological conditions. Using a very simple setup we explore how the dynamic range spanned by upstream and downstream components, and the nonlinearities of a general sigmoidal-shaped module?s response function could be tuned to produce effective sensitivities much less or even larger than the sensitivity associated to the original module when considered in isolation.