INVESTIGADORES
VENTURA Alejandra Cristina
artículos
Título:
Probing a reduced equation for intracellular calcium dynamics
Autor/es:
ALEJANDRA C VENTURA; LUCIANA BRUNO; SILVINA PONCE DAWSON
Revista:
PHYSICA A - STATISTICAL AND THEORETICAL PHYSICS
Editorial:
Elsevier
Referencias:
Año: 2004 vol. 342 p. 281 - 287
ISSN:
0378-4371
Resumen:
Intracellular calcium plays a crucial role in many biological
processes. Optical techniques provide a relatively non-invasive method
by which calcium signals can be studied. However, obtaining
quantitative information on the calcium currents that give rise to a
particular image is not straightforward due to the presence of buffers
and pumps that affect the calcium dynamics. We have recently developed
a novel method to determine the calcium release fluxes that underlie a
fluorescent image, which proved to be pretty accurate in both
numerically and experimentally generated images (Ventura et al., to be
published). The method assumes that a certain number of perturbative
terms is enough to capture the way in which the various intracellular
processes whose details are unknown affect calcium dynamics. In this
paper we investigate the validity of this ansatz using numerical
simulations.