Pioneer factors and ATP-dependent chromatin remodeling factors interact dynamically: A new perspective

ERIN E. SWINSTEAD; VILLE PAAKINAHO; DIEGO M PRESMAN; GORDON L. HAGER

BIOESSAYS

JOHN WILEY & SONS INC

Lugar: New York; Año: 2016

0265-9247

Transcription factor (TF) signaling regulates gene transcriptionand requires a complex network of proteins. Thisnetwork includes co-activators, co-repressors, multipleTFs, histone-modifying complexes, and the basal transcriptionmachinery. It has been widely appreciated thatpioneer factors, such as FoxA1 and GATA1, play animportant role in opening closed chromatin regions,thereby allowing binding of a secondary factor. In thisreview we will focus on a newly proposed model whereinmultiple TFs, such as steroid receptors (SRs), can functionin a pioneering role. This model, termed dynamic assistedloading, integrates data from widely divergent methodologies,including genome wide ChIP-Seq, digital genomicfootprinting, DHS-Seq, live cell protein dynamics, andbiochemical studies of ATP-dependent remodeling complexes,to present a real time view of TF chromatininteractions. Under this view, many TFs can act as initiatingfactors for chromatin landscape programming.