CONICET | Buscador de Institutos y Recursos Humanos

Microorganisms have developed resistance to many antibiotics and as a result, immense clinical problems in the treatment of infectious disease have been emerged. A key strategy to control antibiotic resistance is to stimulate the development of novel antibacterials to continue treating resistant infections. In particular, the antimicrobial activities of extracts and plant essential oil have formed the basis of many alternative medicines and natural therapies. Essential oils of plant origin are among the best known substances to have attracted attention in recent years for you several uses like as potential pest control agents, food preserving, antibacterial, antioxidant and antifungal.The genus Schinus (Anacardiaceae) is a native species from the north-west region of Argentina.It has been reported many traditional uses for S. areira L. like as a purgative, diuretic, parasiticide, insecticide, vulnerary, and topical disinfectant, and for the treatment of rheumatism, stomach upsets, menstrual disorders, bronchitis and conjunctivitis, treatment of colds, as an expectorant, among others. In this work, the essential oil (EO) chemical composition of S. areira from Northwest of Argentina has been determined and its antimicrobial potential. Bioautography assay has been shown, that S. areira EO has antibacterial activity on S. aureus, producing inhibitory effect at 25, 50 and 100 µg. The minimum inhibitory concentration was 62.5 µg.mL-1, showing that at 256 µg.mL-1 a bacteriolytic action. Further studies on the interaction of S. aureus EO with artificial membranes, such as phosphatidylcholine and phosphatidylglycerol liposomes (PC:PG; 5:1 MLVs), indicates that its interaction, produce change in electrical properties of the membrane, producing an increase in Zeta potential of 6 mV. This could indicate that interaction with membrane could be one of target for its antimicrobial mechanism of action.

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