INVESTIGADORES
HOLLMANN Axel
artículos
Título:
The rigid amphipathic fusion inhibitor dUY11 acts through photosensitization of viruses
Autor/es:
VIGANT F; HOLLMANN A; LEE J; SANTOS NC; JUNG ME; LEE B
Revista:
JOURNAL OF VIROLOGY
Editorial:
AMER SOC MICROBIOLOGY
Referencias:
Lugar: Washington; Año: 2014 vol. 88 p. 1849 - 1853
ISSN:
0022-538X
Resumen:
Rigid Amphipathic Fusion Inhibitors (RAFIs) are lipophilic inverted cone-shaped molecules thought to antagonize the membrane curvature transitions that occur during virus-cell fusion, and are broad-spectrum anti-virals against enveloped viruses (Broad-SAVE). Here, we show that RAFIs act like membrane-binding photosensitizers: their antiviral effect is dependent on light and the generation of singlet oxygen (1O2), similar to the mechanistic paradigm established for LJ001, a chemically unrelated class of Broad-SAVE. Photosensitization of viral membranes is a common mechanism that underlies these Broad-SAVE.
